AmiGO 2: Term Details for "phosphatidylinositol 3-kinase/protein kinase B signal transduction" (GO:0043491)

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Term Information

Accession: GO:0043491
Name: phosphatidylinositol 3-kinase/protein kinase B signal transduction
Ontology: biological_process
Synonyms: PI3K-PKB/Akt pathway, PI3K/Akt signal transduction, PI3K/PKB signal transduction, phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction, AKT signal transduction, AKT signaling, AKT signaling cascade, AKT signalling cascade, PKB signal transduction, PKB signaling, PKB signaling cascade, PKB signalling cascade, protein kinase B signal transduction, protein kinase B signaling, protein kinase B signaling cascade, protein kinase B signalling cascade
Alternate IDs: None
Definition: An intracellular signaling cassette that starts with phosphatidylinositol 3-kinase (PI3K) activation, production of phosphatidylinositol 3-phosphate (PI3P), activation of PDK1, which recruits and ending with the activation of protein kinase B (PKB, also known as Akt). PI3K is activated by cell surface receptors. Note that PTEN is an inhibitor of the pathway. Source: PMID:22952397, PMID:20517722
Comment: None
History: See term history for GO:0043491 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to phosphatidylinositol 3-kinase/protein kinase B signal transduction (excluding "regulates").; Link to all direct and indirect annotations to phosphatidylinositol 3-kinase/protein kinase B signal transduction (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for phosphatidylinositol 3-kinase/protein kinase B signal transduction (excluding "regulates").

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For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
GO:0008150 biological_process
CARO:0000006 material anatomical entity
GO:0065007 biological regulation
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
UBERON:0000061 anatomical structure
GO:0009987 cellular process
GO:0005575 cellular_component
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
CL:0000000 cell
GO:0007154 cell communication
GO:0110165 cellular anatomical structure
GO:0051716 cellular response to stimulus
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0005622 intracellular anatomical structure
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction
GO:0141124 intracellular signaling cassette
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

Parents of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0043491)

subject	relation	object
phosphatidylinositol 3-kinase/protein kinase B signal transduction	is_a	intracellular signaling cassette (GO:0141124)

Children of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0043491)

subject	relation	object
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051898)	RO:0002212	phosphatidylinositol 3-kinase/protein kinase B signal transduction
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051896)	RO:0002211	phosphatidylinositol 3-kinase/protein kinase B signal transduction
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051897)	RO:0002213	phosphatidylinositol 3-kinase/protein kinase B signal transduction

Reactome: R-HSA-198693; R-HSA-198203; R-HSA-198323