AmiGO 2: Term Details for "necroptotic process" (GO:0070266)

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Term Information

Accession: GO:0070266
Name: necroptotic process
Ontology: biological_process
Synonyms: RIPK1-mediated regulated necrosis, PARP-dependent cell death, activation of necroptosis, activation of necroptosis by extracellular signals, activation of necroptosis in response to extracellular signals, activation of necroptosis of activated-T cells, establishment of necroptosis, establishment of necroptosis of activated-T cells, extracellular signal-induced necroptosis, parthanatos, TNF-induced necroptosis, necroptosis, induction of necroptosis, induction of necroptosis by extracellular signals, induction of necroptosis of activated-T cells, programmed necrosis, programmed necrotic cell death
Alternate IDs: GO:0060554, GO:0060555, GO:0060553
Definition: A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former. Source: GOC:dph, GOC:tb, PMID:20823910, GOC:BHF, PMID:21760595, GOC:mah, GOC:mtg_apoptosis, PMID:18846107, PMID:21737330, PMID:21876153
Comment: Examples of this are Birc2 and Birc3 (UniProt symbols Q62210 and O08863) in PMID:21052097.
History: See term history for GO:0070266 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to necroptotic process (excluding "regulates").; Link to all direct and indirect annotations to necroptotic process (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for necroptotic process (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0009987 cellular process
GO:0008219 cell death
GO:0012501 programmed cell death
GO:0097300 programmed necrotic cell death
GO:0070266 necroptotic process
GO:0097528 execution phase of necroptosis
GO:0097527 necroptotic signaling pathway
GO:0060546 negative regulation of necroptotic process
GO:0060545 positive regulation of necroptotic process
GO:0060544 regulation of necroptotic process
GO:1901026 ripoptosome assembly involved in necroptotic process

Parents of necroptotic process (GO:0070266)

subject	relation	object
necroptotic process	is_a	programmed necrotic cell death (GO:0097300)

Children of necroptotic process (GO:0070266)

subject	relation	object
execution phase of necroptosis (GO:0097528)	BFO:0000050	necroptotic process
necroptotic signaling pathway (GO:0097527)	BFO:0000050	necroptotic process
positive regulation of necroptotic process (GO:0060545)	RO:0002213	necroptotic process
ripoptosome assembly involved in necroptotic process (GO:1901026)	BFO:0000050	necroptotic process
negative regulation of necroptotic process (GO:0060546)	RO:0002212	necroptotic process
regulation of necroptotic process (GO:0060544)	RO:0002211	necroptotic process

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