AmiGO 2: Term Details for "extrinsic apoptotic signaling pathway" (GO:0097191)

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Term Information

Accession: GO:0097191
Name: extrinsic apoptotic signaling pathway
Ontology: biological_process
Synonyms: extrinsic apoptotic pathway, extrinsic apoptotic signalling pathway, death receptor-mediated apoptosis, extrinsic apoptosis, extrinsic apoptotic signaling pathway in presence of ligand
Alternate IDs: None
Definition: The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. Source: GOC:yaf, GOC:mtg_apoptosis, PMID:17340152
Comment: Fas acts as a death receptor with a role in apoptosis, but can also act as a non-apoptotic signal transducer.
History: See term history for GO:0097191 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to extrinsic apoptotic signaling pathway (excluding "regulates").; Link to all direct and indirect annotations to extrinsic apoptotic signaling pathway (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for extrinsic apoptotic signaling pathway (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0065007 biological regulation
GO:0009987 cellular process
GO:0008219 cell death
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
GO:0007154 cell communication
GO:0051716 cellular response to stimulus
GO:0012501 programmed cell death
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0097190 apoptotic signaling pathway
GO:0007166 cell surface receptor signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:1990117 B cell receptor apoptotic signaling pathway
GO:0071550 death-inducing signaling complex assembly
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:1902178 fibroblast growth factor receptor apoptotic signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001236 regulation of extrinsic apoptotic signaling pathway
GO:1901025 ripoptosome assembly involved in extrinsic apoptotic signaling pathway

Parents of extrinsic apoptotic signaling pathway (GO:0097191)

subject	relation	object
extrinsic apoptotic signaling pathway	RO:0002162	Opisthokonta (NCBITaxon:33154)
extrinsic apoptotic signaling pathway	is_a	cell surface receptor signaling pathway (GO:0007166)
extrinsic apoptotic signaling pathway	is_a	apoptotic signaling pathway (GO:0097190)

Children of extrinsic apoptotic signaling pathway (GO:0097191)

subject	relation	object
ovarian follicle atresia (GO:0001552)	BFO:0000051	extrinsic apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway (GO:2001238)	RO:0002213	extrinsic apoptotic signaling pathway
regulation of extrinsic apoptotic signaling pathway (GO:2001236)	RO:0002211	extrinsic apoptotic signaling pathway
extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)	is_a	extrinsic apoptotic signaling pathway
ripoptosome assembly involved in extrinsic apoptotic signaling pathway (GO:1901025)	BFO:0000050	extrinsic apoptotic signaling pathway
B cell receptor apoptotic signaling pathway (GO:1990117)	is_a	extrinsic apoptotic signaling pathway
fibroblast growth factor receptor apoptotic signaling pathway (GO:1902178)	is_a	extrinsic apoptotic signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)	is_a	extrinsic apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway (GO:2001237)	RO:0002212	extrinsic apoptotic signaling pathway
death-inducing signaling complex assembly (GO:0071550)	BFO:0000050	extrinsic apoptotic signaling pathway

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