AmiGO 2: Term Details for "ferroptosis" (GO:0097707)

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Term Information

Accession: GO:0097707
Name: ferroptosis
Ontology: biological_process
Synonyms: iron-dependent programmed cell death
Alternate IDs: None
Definition: A programmed cell death characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. Activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine/glutamate antiporter are involved in the induction of ferroptosis. This process is characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS) derived from iron metabolism. Glutathione peroxidase 4 (GPX4), heat shock protein beta-1, and nuclear factor erythroid 2-related factor 2 function as negative regulators of ferroptosis by limiting ROS production and reducing cellular iron uptake, respectively. In contrast, NADPH oxidase and p53 act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 (a specific light-chain subunit of the cystine/glutamate antiporter), respectively. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes. Source: PMID:25236395, GOC:mtg_apoptosis, PMID:26794443
Comment: None
History: See term history for GO:0097707 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to ferroptosis (excluding "regulates").; Link to all direct and indirect annotations to ferroptosis (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for ferroptosis (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0009987 cellular process
GO:0008219 cell death
GO:0012501 programmed cell death
GO:0097707 ferroptosis
GO:0110076 negative regulation of ferroptosis
GO:0160020 positive regulation of ferroptosis
GO:0110075 regulation of ferroptosis

Parents of ferroptosis (GO:0097707)

subject	relation	object
ferroptosis	is_a	programmed cell death (GO:0012501)

Children of ferroptosis (GO:0097707)

subject	relation	object
regulation of ferroptosis (GO:0110075)	RO:0002211	ferroptosis
positive regulation of ferroptosis (GO:0160020)	RO:0002213	ferroptosis
negative regulation of ferroptosis (GO:0110076)	RO:0002212	ferroptosis

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