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Wnt10b wingless-type MMTV integration site family, member 10B [ Mus musculus (house mouse) ]

Gene ID: 22410, updated on 9-Dec-2024

Summary

Official Symbol
Wnt10bprovided by MGI
Official Full Name
wingless-type MMTV integration site family, member 10Bprovided by MGI
Primary source
MGI:MGI:108061
See related
Ensembl:ENSMUSG00000022996 AllianceGenome:MGI:108061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wnt12
Summary
Predicted to enable cytokine activity and frizzled binding activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of cell differentiation; and regulation of DNA-templated transcription. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including genitourinary system; integumental system; jaw; nervous system; and surface ectoderm. Human ortholog(s) of this gene implicated in obesity; split hand-foot malformation 6; and tooth agenesis. Orthologous to human WNT10B (Wnt family member 10B). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in ovary adult (RPKM 34.8), lung adult (RPKM 7.4) and 1 other tissue See more
Orthologs
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Genomic context

See Wnt10b in Genome Data Viewer
Location:
15 F1; 15 54.65 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98668593..98676093, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98770712..98778206, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene FK506 binding protein 11 Neighboring gene ARF GTPase 3 Neighboring gene uncharacterized LOC115488470 Neighboring gene wingless-type MMTV integration site family, member 1 Neighboring gene dendrin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity  
enables frizzled binding  
enables signaling receptor binding PubMed 
Items 1 - 25 of 63
Process Evidence Code Pubs
acts_upstream_of_or_within G2/M transition of mitotic cell cycle PubMed 
acts_upstream_of T cell differentiation PubMed 
acts_upstream_of_or_within Wnt signaling pathway PubMed 
acts_upstream_of anagen PubMed 
acts_upstream_of_or_within animal organ morphogenesis PubMed 
acts_upstream_of_or_within bone trabecula formation PubMed 
involved_in canonical Wnt signaling pathway  
acts_upstream_of_or_within canonical Wnt signaling pathway PubMed 
involved_in canonical Wnt signaling pathway  
involved_in cell fate commitment  
acts_upstream_of cell population proliferation PubMed 
acts_upstream_of_or_within cell-cell signaling PubMed 
acts_upstream_of_or_within cellular response to cAMP PubMed 
acts_upstream_of_or_within cellular response to organic cyclic compound PubMed 
acts_upstream_of_or_within cellular response to parathyroid hormone stimulus PubMed 
involved_in chondrocyte differentiation  
acts_upstream_of epithelial cell differentiation PubMed 
acts_upstream_of fat cell differentiation PubMed 
acts_upstream_of_or_within fungiform papilla development PubMed 
acts_upstream_of hematopoietic stem cell proliferation PubMed 
acts_upstream_of_or_within hematopoietic stem cell proliferation PubMed 
involved_in hematopoietic stem cell proliferation  
acts_upstream_of_or_within lipid metabolic process PubMed 
acts_upstream_of_or_within myoblast development PubMed 
acts_upstream_of_or_within myoblast differentiation involved in skeletal muscle regeneration PubMed 
involved_in negative regulation of cold-induced thermogenesis PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell proliferation PubMed 
acts_upstream_of_or_within negative regulation of fat cell differentiation PubMed 
involved_in negative regulation of fat cell differentiation  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
involved_in neuron differentiation  
acts_upstream_of osteoblast differentiation PubMed 
acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity PubMed 
acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle PubMed 
acts_upstream_of_or_within positive regulation of RNA polymerase II transcription preinitiation complex assembly PubMed 
acts_upstream_of_or_within positive regulation of T cell differentiation PubMed 
involved_in positive regulation of apoptotic process  
involved_in positive regulation of apoptotic process  
acts_upstream_of_or_within positive regulation of bone mineralization PubMed 
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell differentiation PubMed 
acts_upstream_of_or_within positive regulation of hematopoietic stem cell proliferation PubMed 
acts_upstream_of_or_within positive regulation of ossification PubMed 
acts_upstream_of_or_within positive regulation of ossification PubMed 
acts_upstream_of_or_within positive regulation of osteoblast differentiation PubMed 
acts_upstream_of_or_within positive regulation of timing of anagen PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
involved_in protein stabilization  
involved_in protein stabilization  
acts_upstream_of_or_within regulation of cell cycle PubMed 
acts_upstream_of_or_within regulation of fat cell differentiation PubMed 
acts_upstream_of_or_within regulation of proteasomal ubiquitin-dependent protein catabolic process PubMed 
acts_upstream_of_or_within regulation of proteasomal ubiquitin-dependent protein catabolic process PubMed 
acts_upstream_of_or_within regulation of protein metabolic process PubMed 
acts_upstream_of_or_within regulation of skeletal muscle tissue development PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within sensory perception of taste PubMed 
acts_upstream_of_or_within signal transduction PubMed 
acts_upstream_of_or_within skeletal muscle fiber development PubMed 
acts_upstream_of_or_within skeletal muscle tissue regeneration PubMed 
acts_upstream_of_or_within smoothened signaling pathway PubMed 
acts_upstream_of transcription by RNA polymerase II PubMed 
Items 1 - 25 of 63
Component Evidence Code Pubs
located_in extracellular region  
is_active_in extracellular space  

General protein information

Preferred Names
protein Wnt-10b
Names
wingless related MMTV integration site 10b
wnt-12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011718.2NP_035848.1  protein Wnt-10b precursor

    See identical proteins and their annotated locations for NP_035848.1

    Status: VALIDATED

    Source sequence(s)
    BC114969, U30464, U61970
    Consensus CDS
    CCDS27806.1
    UniProtKB/Swiss-Prot
    P48614, P70702
    Related
    ENSMUSP00000023732.6, ENSMUST00000023732.12
    Conserved Domains (1) summary
    cd19356
    Location:45389
    Wnt_Wnt10b; Wnt domain found in protein Wnt-10b and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    98668593..98676093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520892.5XP_006520955.1  protein Wnt-10b isoform X2

    See identical proteins and their annotated locations for XP_006520955.1

    UniProtKB/Swiss-Prot
    P48614
    Related
    ENSMUSP00000154513.2, ENSMUST00000226846.2
    Conserved Domains (1) summary
    cl38924
    Location:45293
    Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family
  2. XM_006520891.4XP_006520954.1  protein Wnt-10b isoform X1

    See identical proteins and their annotated locations for XP_006520954.1

    UniProtKB/Swiss-Prot
    P48614, P70702
    Conserved Domains (1) summary
    cd19356
    Location:45389
    Wnt_Wnt10b; Wnt domain found in protein Wnt-10b and similar proteins
  3. XM_006520893.2XP_006520956.1  protein Wnt-10b isoform X3

    Conserved Domains (1) summary
    cl38924
    Location:1267
    Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family
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