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Habp4 hyaluronic acid binding protein 4 [ Mus musculus (house mouse) ]

Gene ID: 56541, updated on 9-Dec-2024

Summary

Official Symbol
Habp4provided by MGI
Official Full Name
hyaluronic acid binding protein 4provided by MGI
Primary source
MGI:MGI:1891713
See related
Ensembl:ENSMUSG00000021476 AllianceGenome:MGI:1891713
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933413D03Rik; 4933428J01Rik
Summary
Predicted to enable several functions, including SUMO binding activity; hyaluronic acid binding activity; and translation elongation factor binding activity. Predicted to be involved in PML body organization; cellular response to mechanical stimulus; and regulation of gene expression. Predicted to act upstream of or within hyaluronan metabolic process. Located in cytoplasm. Is active in synapse. Is expressed in central nervous system; ovary; retina; and white fat. Orthologous to human HABP4 (hyaluronan binding protein 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in testis adult (RPKM 67.5), cortex adult (RPKM 46.4) and 25 other tissues See more
Orthologs
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Genomic context

See Habp4 in Genome Data Viewer
Location:
13 B3; 13 33.26 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (64309680..64334351)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (64161866..64186537)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member D2 Neighboring gene zinc finger protein 367 Neighboring gene STARR-seq mESC enhancer starr_34820 Neighboring gene STARR-positive B cell enhancer ABC_E5404 Neighboring gene STARR-positive B cell enhancer ABC_E928 Neighboring gene STARR-positive B cell enhancer ABC_E7250 Neighboring gene CDC14 cell division cycle 14B Neighboring gene STARR-seq mESC enhancer starr_34826 Neighboring gene predicted gene, 46424 Neighboring gene RIKEN cDNA 1810034E14 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding  
enables RNA binding  
enables SUMO binding  
enables SUMO binding  
enables hyaluronic acid binding PubMed 
enables ribosome binding  
enables translation elongation factor binding  
Process Evidence Code Pubs
involved_in PML body organization  
involved_in PML body organization  
involved_in RNA splicing  
involved_in cellular response to mechanical stimulus  
involved_in cellular response to mechanical stimulus  
acts_upstream_of_or_within hyaluronan metabolic process PubMed 
involved_in mRNA processing  
involved_in negative regulation of DNA binding  
involved_in negative regulation of DNA binding  
involved_in positive regulation of RNA splicing  
involved_in positive regulation of RNA splicing  
involved_in positive regulation of RNA splicing  
involved_in positive regulation of translational initiation  
involved_in positive regulation of translational initiation  
involved_in positive regulation of translational initiation  
involved_in ribosome hibernation  
Items 1 - 20 of 23
Component Evidence Code Pubs
located_in Cajal body  
located_in Cajal body  
located_in Gemini of coiled bodies  
located_in Gemini of coiled bodies  
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytoplasm PubMed 
located_in cytoplasmic stress granule  
located_in cytoplasmic stress granule  
located_in cytosol  
located_in nuclear membrane  
located_in nuclear speck  
located_in nuclear speck  
located_in nucleolus  
located_in nucleolus  
is_active_in nucleus  
located_in nucleus  
located_in nucleus  
located_in sarcomere  
located_in sarcomere  
located_in sarcoplasm  
is_active_in synapse PubMed 
is_active_in synapse PubMed 
Items 1 - 20 of 23

General protein information

Preferred Names
intracellular hyaluronan-binding protein 4
Names
IHABP-4
IHABP4
hyaluronic acid-binding protein 4 (intracellular)
intracellular hyaluronan-binding protein p57

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019986.3NP_064370.2  intracellular hyaluronan-binding protein 4

    Status: VALIDATED

    Source sequence(s)
    AK016800, AK146525, CD776978
    Consensus CDS
    CCDS36702.1
    UniProtKB/Swiss-Prot
    Q3UNH8, Q9D450, Q9JKS5
    UniProtKB/TrEMBL
    E9QKB2
    Related
    ENSMUSP00000021929.9, ENSMUST00000021929.10
    Conserved Domains (2) summary
    pfam04774
    Location:212315
    HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
    pfam16174
    Location:16131
    IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    64309680..64334351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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