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Dennd6b DENN domain containing 6B [ Mus musculus (house mouse) ]

Gene ID: 69440, updated on 9-Dec-2024

Summary

Official Symbol
Dennd6bprovided by MGI
Official Full Name
DENN domain containing 6Bprovided by MGI
Primary source
MGI:MGI:1916690
See related
Ensembl:ENSMUSG00000015377 AllianceGenome:MGI:1916690
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam116b; 1700027J05Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in recycling endosome. Is expressed in central nervous system; dorsal root ganglion; and neural retina. Orthologous to human DENND6B (DENN domain containing 6B). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in CNS E18 (RPKM 33.8), cerebellum adult (RPKM 32.4) and 27 other tissues See more
Orthologs
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Genomic context

See Dennd6b in Genome Data Viewer
Location:
15 E3; 15 44.7 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89066416..89080793, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89182213..89198427, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 11 Neighboring gene plexin B2 Neighboring gene microRNA 7118 Neighboring gene STARR-seq mESC enhancer starr_39459 Neighboring gene microRNA 6958 Neighboring gene STARR-positive B cell enhancer ABC_E3151 Neighboring gene STARR-positive B cell enhancer ABC_E4146 Neighboring gene protein phosphatase 6, regulatory subunit 2 Neighboring gene SET binding factor 1 Neighboring gene microRNA 6959

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in recycling endosome  
located_in recycling endosome  

General protein information

Preferred Names
protein DENND6B
Names
DENN domain-containing protein 6B
DENN/MADD domain containing 6B
family with sequence similarity 116, member B
protein FAM116B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027081.3NP_081357.2  protein DENND6B

    See identical proteins and their annotated locations for NP_081357.2

    Status: VALIDATED

    Source sequence(s)
    AK006427, BB658928, BC058958, BQ444357, BY252285
    Consensus CDS
    CCDS57000.1
    UniProtKB/Swiss-Prot
    B2RSU3, Q9D9V7
    Related
    ENSMUSP00000077978.8, ENSMUST00000078953.9
    Conserved Domains (2) summary
    pfam08616
    Location:250356
    SPA; Stabilization of polarity axis
    cl11519
    Location:151311
    DENN; DENN (AEX-3) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    89066416..89080793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248748.1XP_030104608.1  protein DENND6B isoform X3

    Conserved Domains (2) summary
    pfam08616
    Location:126232
    SPA; Stabilization of polarity axis
    cl11519
    Location:28187
    DENN; DENN (AEX-3) domain
  2. XM_030248747.2XP_030104607.1  protein DENND6B isoform X2

    Conserved Domains (2) summary
    pfam08616
    Location:153259
    SPA; Stabilization of polarity axis
    cl11519
    Location:54214
    DENN; DENN (AEX-3) domain
  3. XM_030248744.2XP_030104604.1  protein DENND6B isoform X1

    Conserved Domains (2) summary
    pfam08616
    Location:223329
    SPA; Stabilization of polarity axis
    cl11519
    Location:125284
    DENN; DENN (AEX-3) domain
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