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Klhdc2 kelch domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 69554, updated on 9-Dec-2024

Summary

Official Symbol
Klhdc2provided by MGI
Official Full Name
kelch domain containing 2provided by MGI
Primary source
MGI:MGI:1916804
See related
Ensembl:ENSMUSG00000020978 AllianceGenome:MGI:1916804
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LCP; HCLP-1; D12Ertd522e; 2310022K15Rik
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to be located in nuclear body and nuclear membrane. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human KLHDC2 (kelch domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 57.4), CNS E18 (RPKM 56.1) and 28 other tissues See more
Orthologs
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Genomic context

See Klhdc2 in Genome Data Viewer
Location:
12 C2; 12 28.77 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (69343455..69357461)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (69296681..69310687)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9330151L19 gene Neighboring gene dynein, axonemal assembly factor 2 Neighboring gene STARR-seq mESC enhancer starr_32361 Neighboring gene polymerase (DNA directed), epsilon 2 (p59 subunit) Neighboring gene STARR-positive B cell enhancer ABC_E10753 Neighboring gene kelch domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_32363 Neighboring gene nuclear export mediator factor Neighboring gene STARR-seq mESC enhancer starr_32364 Neighboring gene STARR-positive B cell enhancer ABC_E10754 Neighboring gene STARR-positive B cell enhancer ABC_E7139 Neighboring gene STARR-positive B cell enhancer ABC_E600 Neighboring gene 7S RNA 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3) 

Interactions

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex  
part_of Cul2-RING ubiquitin ligase complex  
located_in nuclear body  
located_in nuclear body  
located_in nuclear membrane  
located_in nuclear membrane  
located_in nucleoplasm  
is_active_in nucleus  
is_active_in nucleus  

General protein information

Preferred Names
kelch domain-containing protein 2
Names
endothelial differentiation inhibitory protein TNG

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027117.3NP_081393.2  kelch domain-containing protein 2

    See identical proteins and their annotated locations for NP_081393.2

    Status: VALIDATED

    Source sequence(s)
    AC099934, AK009481
    Consensus CDS
    CCDS25950.1
    UniProtKB/Swiss-Prot
    E9QKN6, Q4G5Y1, Q99JY2, Q9D784
    Related
    ENSMUSP00000021362.5, ENSMUST00000021362.5
    Conserved Domains (3) summary
    PLN02193
    Location:29296
    PLN02193; nitrile-specifier protein
    sd00038
    Location:218265
    Kelch; KELCH repeat [structural motif]
    pfam13415
    Location:279326
    Kelch_3; Galactose oxidase, central domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    69343455..69357461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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