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Adamtsl1 ADAMTS-like 1 [ Mus musculus (house mouse) ]

Gene ID: 77739, updated on 9-Dec-2024

Summary

Official Symbol
Adamtsl1provided by MGI
Official Full Name
ADAMTS-like 1provided by MGI
Primary source
MGI:MGI:1924989
See related
Ensembl:ENSMUSG00000066113 AllianceGenome:MGI:1924989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ADAMTSL-1; 5930437A14Rik; 6720426B09Rik
Summary
Predicted to be involved in extracellular matrix organization. Located in collagen-containing extracellular matrix. Orthologous to human ADAMTSL1 (ADAMTS like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in bladder adult (RPKM 6.7), limb E14.5 (RPKM 4.3) and 21 other tissues See more
Orthologs
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Genomic context

See Adamtsl1 in Genome Data Viewer
Location:
4 C4; 4 40.32 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (85432242..86346627)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (85513852..86428390)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10676 Neighboring gene STARR-seq mESC enhancer starr_10677 Neighboring gene STARR-seq mESC enhancer starr_10679 Neighboring gene RAN, member RAS oncogene family pseudogene Neighboring gene SH3-domain GRB2-like 2 Neighboring gene phosphoglycerate mutase 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_10684 Neighboring gene STARR-seq mESC enhancer starr_10685 Neighboring gene STARR-seq mESC enhancer starr_10686 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-seq mESC enhancer starr_10687 Neighboring gene predicted gene, 25811 Neighboring gene STARR-seq mESC enhancer starr_10689 Neighboring gene STARR-seq mESC enhancer starr_10690 Neighboring gene STARR-seq mESC enhancer starr_10691 Neighboring gene STARR-seq mESC enhancer starr_10692 Neighboring gene STARR-seq mESC enhancer starr_10693 Neighboring gene predicted gene, 33730 Neighboring gene STARR-positive B cell enhancer mm9_chr4:86183948-86184249 Neighboring gene stabilizer of axonemal microtubules 1 Neighboring gene predicted gene, 26017 Neighboring gene stabilizer of axonemal microtubules 1, opposite strand

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in collagen-containing extracellular matrix PubMed 
is_active_in extracellular matrix  
located_in extracellular region  

General protein information

Preferred Names
ADAMTS-like protein 1
Names
punctin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368621.1NP_001355550.1  ADAMTS-like protein 1 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL772130, AL807242, AL824705
    UniProtKB/Swiss-Prot
    A2AM52, Q8BLI0
    Related
    ENSMUSP00000119278.2, ENSMUST00000141889.8
    Conserved Domains (7) summary
    smart00408
    Location:891949
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:3682
    TSP1; Thrombospondin type 1 repeats
    PTZ00441
    Location:434506
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    cd00096
    Location:13041375
    Ig; Immunoglobulin domain
    cl15278
    Location:529583
    TSP_1; Thrombospondin type 1 domain
    pfam07679
    Location:14141494
    I-set; Immunoglobulin I-set domain
    pfam08686
    Location:17381767
    PLAC; PLAC (protease and lacunin) domain
  2. NM_029967.3NP_084243.3  ADAMTS-like protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AK020115, AK045085, AK132420, AL807242, AL824705, CJ051149, CV555842
    Consensus CDS
    CCDS51217.1
    UniProtKB/Swiss-Prot
    A2AM52, Q8BLI0
    UniProtKB/TrEMBL
    E9PWW5
    Related
    ENSMUSP00000102796.3, ENSMUST00000107178.9
    Conserved Domains (6) summary
    smart00408
    Location:12841351
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:3682
    TSP1; Thrombospondin type 1 repeats
    smart00410
    Location:12691361
    IG_like; Immunoglobulin like
    pfam08686
    Location:17211750
    PLAC; PLAC (protease and lacunin) domain
    cl11960
    Location:11801240
    Ig; Immunoglobulin domain
    cl15278
    Location:514566
    TSP_1; Thrombospondin type 1 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    85432242..86346627
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538375.3XP_006538438.1  ADAMTS-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2AM52, Q8BLI0
    Conserved Domains (6) summary
    smart00408
    Location:16471713
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:265311
    TSP1; Thrombospondin type 1 repeats
    PTZ00441
    Location:663735
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    cd00096
    Location:15331604
    Ig; Immunoglobulin domain
    pfam08686
    Location:19671996
    PLAC; PLAC (protease and lacunin) domain
    cl15278
    Location:760812
    TSP_1; Thrombospondin type 1 domain
  2. XM_006538376.3XP_006538439.1  ADAMTS-like protein 1 isoform X2

    UniProtKB/Swiss-Prot
    A2AM52, Q8BLI0
    Conserved Domains (5) summary
    smart00408
    Location:16301696
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:265311
    TSP1; Thrombospondin type 1 repeats
    PTZ00441
    Location:646718
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    cd00096
    Location:15161587
    Ig; Immunoglobulin domain
    cl15278
    Location:743795
    TSP_1; Thrombospondin type 1 domain
  3. XM_036164549.1XP_036020442.1  ADAMTS-like protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AM52, Q8BLI0
    Conserved Domains (7) summary
    smart00408
    Location:10781136
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:223269
    TSP1; Thrombospondin type 1 repeats
    pfam08686
    Location:19251954
    PLAC; PLAC (protease and lacunin) domain
    pfam13927
    Location:14721552
    Ig_3; Immunoglobulin domain
    pfam19030
    Location:857915
    TSP1_ADAMTS; Thrombospondin type 1 domain
    cd00096
    Location:14911495
    Ig; Ig strand B [structural motif]
    cl11960
    Location:13841444
    Ig; Immunoglobulin domain
  4. XM_006538378.5XP_006538441.1  ADAMTS-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_006538441.1

    UniProtKB/Swiss-Prot
    A2AM52, Q8BLI0
    Conserved Domains (5) summary
    smart00408
    Location:14181484
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:3682
    TSP1; Thrombospondin type 1 repeats
    PTZ00441
    Location:434506
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    cd00096
    Location:13041375
    Ig; Immunoglobulin domain
    cl15278
    Location:531583
    TSP_1; Thrombospondin type 1 domain
  5. XM_036164550.1XP_036020443.1  ADAMTS-like protein 1 isoform X5

    UniProtKB/Swiss-Prot
    A2AM52, Q8BLI0
    Conserved Domains (6) summary
    smart00408
    Location:874932
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:3682
    TSP1; Thrombospondin type 1 repeats
    pfam13927
    Location:12681348
    Ig_3; Immunoglobulin domain
    pfam19030
    Location:653711
    TSP1_ADAMTS; Thrombospondin type 1 domain
    cd00096
    Location:12871291
    Ig; Ig strand B [structural motif]
    cl11960
    Location:11801240
    Ig; Immunoglobulin domain
  6. XM_030253919.2XP_030109779.1  ADAMTS-like protein 1 isoform X6

    Conserved Domains (4) summary
    smart00408
    Location:9501016
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:322381
    TSP1; Thrombospondin type 1 repeats
    cd00096
    Location:836907
    Ig; Immunoglobulin domain
    cl15278
    Location:63115
    TSP_1; Thrombospondin type 1 domain
  7. XM_006538380.3XP_006538443.1  ADAMTS-like protein 1 isoform X6

    See identical proteins and their annotated locations for XP_006538443.1

    Conserved Domains (4) summary
    smart00408
    Location:9501016
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:322381
    TSP1; Thrombospondin type 1 repeats
    cd00096
    Location:836907
    Ig; Immunoglobulin domain
    cl15278
    Location:63115
    TSP_1; Thrombospondin type 1 domain
  8. XM_006538379.4XP_006538442.1  ADAMTS-like protein 1 isoform X6

    See identical proteins and their annotated locations for XP_006538442.1

    Conserved Domains (4) summary
    smart00408
    Location:9501016
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:322381
    TSP1; Thrombospondin type 1 repeats
    cd00096
    Location:836907
    Ig; Immunoglobulin domain
    cl15278
    Location:63115
    TSP_1; Thrombospondin type 1 domain

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