Fuca1 (alpha-L-fucosidase 1) - Rat Genome Database

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Gene: Fuca1 (alpha-L-fucosidase 1) Rattus norvegicus
Analyze
Symbol: Fuca1
Name: alpha-L-fucosidase 1
RGD ID: 2636
Description: Enables carbohydrate binding activity and fucosidase activity. Predicted to be involved in fucose metabolic process and glycoside catabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in lysosome. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in fucosidosis. Orthologous to human FUCA1 (alpha-L-fucosidase 1); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alpha-L-fucosidase; alpha-L-fucosidase I; alpha-L-fucoside fucohydrolase 1; Fuca; Fucosidase alpha-L-1 tissue; fucosidase, alpha-L- 1, tissue; Fucosidase, alpha-L-1, tissue; tissue alpha-L-fucosidase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85153,436,262 - 153,453,512 (+)NCBIGRCr8
mRatBN7.25148,152,718 - 148,169,972 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5148,152,700 - 148,169,972 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5150,851,447 - 150,868,992 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05152,625,717 - 152,643,262 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05152,607,730 - 152,625,275 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05154,269,296 - 154,286,545 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5154,269,118 - 154,286,544 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05158,034,147 - 158,051,397 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45154,703,722 - 154,720,971 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15154,713,770 - 154,731,009 (+)NCBI
Celera5146,559,858 - 146,577,113 (+)NCBICelera
RH 3.4 Map51003.4RGD
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP)
capecitabine  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
doxifluridine  (ISO)
doxorubicin  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
ivermectin  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
ochratoxin A  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
propiconazole  (EXP)
protein kinase inhibitor  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
topotecan  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Isolation and sequence analysis of a cDNA encoding rat liver alpha-L-fucosidase. Fisher KJ and Aronson NN Jr, Biochem J 1989 Dec 15;264(3):695-701.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Serum enzymes of lysosomal origin as indicators of the metabolic control in diabetes: comparison with glycated hemoglobin and albumin. Goi G, etal., Acta Diabetol Lat. 1986 Apr-Jun;23(2):117-25.
5. Plasma acidic glycohydrolases in insulin-dependent diabetes mellitus. Kohler E, etal., Acta Diabetol Lat. 1981 Jul-Sep;18(3):243-50.
6. Alterations of glycosaminoglycan metabolism in the development of diabetic complications in relation to metabolic control. Komosinska-Vassev K, etal., Clin Chem Lab Med. 2005;43(9):924-9.
7. Characterization of EcoRI mutation in fucosidosis patients: a stop codon in the open reading frame. Kretz KA, etal., J Mol Neurosci. 1989;1(3):177-80.
8. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
9. Effect of diabetes mellitus on selected acid hydrolase activities in human platelets. Leoncini G, etal., Diabete Metab. 1987 Jun;13(3):198-204.
10. Prospective study of the enzymatic activities in urine of N-acetyl-beta-D-glucosaminidase, alpha-D-mannosidase, alpha- and beta-D-glucosidases, alpha-L- and beta-D-fucosidases, and beta-D-galactosidase in type I diabetes mellitus with early nephropathy. Miralles JM, etal., J Diabetes Complications. 1993 Jul-Sep;7(3):199-203.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
14. In vitro and in vivo alterations of enzymatic glycosylation in diabetes. Rellier N, etal., Life Sci. 1999;64(17):1571-83.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Carbohydrate contents, and glycosidase and glycosyl transferase activities in tissues from streptozotocin diabetic mice. Serrano MA, etal., Comp Biochem Physiol B. 1985;80(3):629-32.
20. Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis. Sleat DE, etal., J Biol Chem. 1996 Aug 9;271(32):19191-8.
21. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
23. Increases in plasma lysosomal enzymes in type 1 (insulin-dependent) diabetes mellitus: relationship to diabetic complications and glycaemic control. Waters PJ, etal., Diabetologia. 1992 Oct;35(10):991-5.
Additional References at PubMed
PMID:15489334   PMID:19056867   PMID:19666478   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Fuca1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85153,436,262 - 153,453,512 (+)NCBIGRCr8
mRatBN7.25148,152,718 - 148,169,972 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5148,152,700 - 148,169,972 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5150,851,447 - 150,868,992 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05152,625,717 - 152,643,262 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05152,607,730 - 152,625,275 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05154,269,296 - 154,286,545 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5154,269,118 - 154,286,544 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05158,034,147 - 158,051,397 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45154,703,722 - 154,720,971 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15154,713,770 - 154,731,009 (+)NCBI
Celera5146,559,858 - 146,577,113 (+)NCBICelera
RH 3.4 Map51003.4RGD
Cytogenetic Map5q36NCBI
FUCA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38123,845,077 - 23,868,290 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl123,845,077 - 23,868,290 (-)EnsemblGRCh38hg38GRCh38
GRCh37124,171,567 - 24,194,780 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36124,044,154 - 24,067,408 (-)NCBINCBI36Build 36hg18NCBI36
Build 34123,916,879 - 23,940,079NCBI
Celera122,500,442 - 22,523,489 (-)NCBICelera
Cytogenetic Map1p36.11NCBI
HuRef122,423,234 - 22,446,489 (-)NCBIHuRef
CHM1_1124,284,300 - 24,307,588 (-)NCBICHM1_1
T2T-CHM13v2.0123,680,157 - 23,703,377 (-)NCBIT2T-CHM13v2.0
Fuca1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394135,648,037 - 135,667,611 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4135,648,046 - 135,667,622 (+)EnsemblGRCm39 Ensembl
GRCm384135,920,726 - 135,940,300 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4135,920,735 - 135,940,311 (+)EnsemblGRCm38mm10GRCm38
MGSCv374135,476,641 - 135,496,215 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364135,192,833 - 135,212,389 (+)NCBIMGSCv36mm8
Celera4134,121,527 - 134,141,456 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map468.01NCBI
Fuca1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554523,744,755 - 3,759,676 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554523,744,071 - 3,759,776 (-)NCBIChiLan1.0ChiLan1.0
FUCA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21203,072,184 - 203,093,659 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11202,175,209 - 202,196,548 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0123,039,126 - 23,060,514 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1124,022,960 - 24,043,850 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl124,022,967 - 24,043,850 (-)Ensemblpanpan1.1panPan2
FUCA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,665,473 - 75,677,087 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,665,469 - 75,688,629 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha272,235,627 - 72,247,237 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0276,224,732 - 76,236,351 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl276,224,694 - 76,243,380 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,047,152 - 73,058,769 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,053,782 - 74,065,389 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0275,059,639 - 75,071,248 (+)NCBIUU_Cfam_GSD_1.0
Fuca1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505843,170,743 - 43,187,687 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364748,996,129 - 9,012,310 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364748,995,525 - 9,012,396 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FUCA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl681,637,994 - 81,656,068 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1681,638,213 - 81,655,993 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2675,370,073 - 75,388,852 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103225962
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120108,823,047 - 108,832,926 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366648224,561 - 46,953 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fuca1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247648,371,167 - 8,386,134 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247648,371,251 - 8,385,855 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fuca1
145 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:47
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000012455
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat

Markers in Region
D5Mco22  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.05158,051,883 - 158,052,146NCBIRnor5.0
RGSC_v3.45154,721,462 - 154,721,724RGDRGSC3.4
RGSC_v3.15154,731,501 - 154,731,763RGD
Cytogenetic Map5q36UniSTS
D5Got277  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25148,160,391 - 148,160,527 (+)MAPPERmRatBN7.2
Rnor_6.05154,276,966 - 154,277,101NCBIRnor6.0
Rnor_5.05158,041,817 - 158,041,952UniSTSRnor5.0
RGSC_v3.45154,711,392 - 154,711,527UniSTSRGSC3.4
Celera5146,567,538 - 146,567,673UniSTS
Cytogenetic Map5q36UniSTS
RH94576  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25148,169,892 - 148,169,971 (+)MAPPERmRatBN7.2
Rnor_6.05154,286,466 - 154,286,544NCBIRnor6.0
Rnor_5.05158,051,318 - 158,051,396UniSTSRnor5.0
RGSC_v3.45154,720,892 - 154,720,970UniSTSRGSC3.4
Celera5146,577,034 - 146,577,112UniSTS
RH 3.4 Map51003.4UniSTS
Cytogenetic Map5q36UniSTS
AI579525  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map51003.0UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 3 4 74 35 41 11 3
Low 5 7 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012455   ⟹   ENSRNOP00000012455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5148,152,700 - 148,169,972 (+)Ensembl
Rnor_6.0 Ensembl5154,269,118 - 154,286,544 (+)Ensembl
RefSeq Acc Id: NM_012562   ⟹   NP_036694
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85153,436,262 - 153,453,512 (+)NCBI
mRatBN7.25148,152,718 - 148,169,972 (+)NCBI
Rnor_6.05154,269,296 - 154,286,545 (+)NCBI
Rnor_5.05158,034,147 - 158,051,397 (+)NCBI
RGSC_v3.45154,703,722 - 154,720,971 (+)RGD
Celera5146,559,858 - 146,577,113 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036694 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH81844 (Get FASTA)   NCBI Sequence Viewer  
  CAA34268 (Get FASTA)   NCBI Sequence Viewer  
  EDL80777 (Get FASTA)   NCBI Sequence Viewer  
  EDL80778 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012455
  ENSRNOP00000012455.3
GenBank Protein P17164 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_036694   ⟸   NM_012562
- Peptide Label: precursor
- UniProtKB: Q642C6 (UniProtKB/Swiss-Prot),   P17164 (UniProtKB/Swiss-Prot),   A0A0G2JSJ8 (UniProtKB/TrEMBL),   A6IT76 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012455   ⟸   ENSRNOT00000012455
Protein Domains
Alpha-L-fucosidase C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17164-F1-model_v2 AlphaFold P17164 1-462 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694161
Promoter ID:EPDNEW_R4685
Type:initiation region
Name:Fuca1_1
Description:alpha-L-fucosidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05154,269,300 - 154,269,360EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2636 AgrOrtholog
BioCyc Gene G2FUF-39524 BioCyc
Ensembl Genes ENSRNOG00000009325 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012455 ENTREZGENE
  ENSRNOT00000012455.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.1180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycosidases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FUC_metazoa-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fucosidase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_29_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24375 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24375 ENTREZGENE
PANTHER PTHR10030 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10030:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Alpha_L_fucos UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fucosidase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fuca1 PhenoGen
PIRSF Alpha-L-fucosidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GLHYDRLASE29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALPHA_L_FUCOSIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009325 RatGTEx
SMART Alpha_L_fucos UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217512
UniProt A0A0G2JSJ8 ENTREZGENE, UniProtKB/TrEMBL
  A6IT76 ENTREZGENE, UniProtKB/TrEMBL
  FUCO_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q642C6 ENTREZGENE
UniProt Secondary Q642C6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-07-05 Fuca1  alpha-L-fucosidase 1  Fuca1  fucosidase, alpha-L- 1, tissue  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Fuca1  fucosidase, alpha-L- 1, tissue  Fuca  fucosidase, alpha-L- 1, tissue  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Fuca  Fucosidase, alpha-L-1, tissue    fucosidase, alpha-L-1, tissue  Symbol and Name updated 629477 APPROVED
2003-03-14 Fuca  Fucosidase, alpha-L-1, tissue  Fuca1    Data merged from RGD:620602 628472 PROVISIONAL
2002-08-07 Fuca1        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Fuca  Fucosidase, alpha-L-1, tissue      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 632702
gene_homology sequence is 82% similar to human fucosidase 632702
gene_protein 434 amino acid in size, has a high tyrptophan content 632702