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Proper Citation: RRID:BCBC_1261
Description: Backcrossing of the Rag1 null allele onto the NOD/Lt strain background (NOD-Rag1null mice) provided a radio-resistant and longer-lived model for human-cell engraftment. Mutations in X-chromosome-linked Il2rg gene cause X-linked severe combined immunodeficiency (XSCID). Immunodeficient NOD-Rag1null IL2rg nullmice tolerated much higher levels of irradiation conditioning than did NOD-Prkdcscid IL2rgnull mice. This immunodeficient mouse also develops spontaneous hyperglycemia based on the Ins2Akita mutation.
Species: Mus musculus
Notes: Backcrossing of the Rag1 null allele onto the NOD/Lt strain background (NOD-Rag1null mice) provided a radio-resistant and longer-lived model for human-cell engraftment. Mutations in X-chromosome-linked Il2rg gene cause X-linked severe combined immunodeficiency (XSCID). Immunodeficient NOD-Rag1null IL2rg nullmice tolerated much higher levels of irradiation conditioning than did NOD-Prkdcscid IL2rgnull mice. This immunodeficient mouse also develops spontaneous hyperglycemia based on the Ins2Akita mutation.
Phenotype: Diabetes mellitus
Affected Gene: recombination activating gene 1
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No rating or validation information has been found for NOD-Rag1nullIL2rgnullIns2Akita (NOD.Cg-Rag1tm1MomIns2AkitaIl2rgtm1Wjl/Sz).
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Source: Integrated Animals
Source Database: BCBC, Beta Cell Biology Consortium