URL: https://web.expasy.org/cellosaurus/CVCL_3509
Proper Citation: (RRID:CVCL_3509)
Description: Cell line ES-2 is a Cancer cell line with a species of origin Homo sapiens (Human)
Sex: Female
Disease: Ovarian clear cell adenocarcinoma
Defining Citation: PMID:1717140, PMID:9698466, PMID:11103784, PMID:12960427, PMID:16382445, PMID:17671176, PMID:18560578, PMID:18720132, PMID:20081105, PMID:20204287, PMID:20215515, PMID:22328975, PMID:22460905, PMID:22705003, PMID:22710073, PMID:23415752, PMID:23839242, PMID:24023729, PMID:25049276, PMID:25230021, PMID:25485619, PMID:25877200, PMID:25960936, PMID:26388441, PMID:26589293, PMID:27397505, PMID:28196595, PMID:28273451, PMID:30485824, PMID:30894373, PMID:30971826, PMID:31068700, PMID:35839778
Comments: Omics: Transcriptome analysis by serial analysis of gene expression (SAGE)., Omics: Transcriptome analysis by RNAseq., Omics: Transcriptome analysis by microarray., Omics: SNP array analysis., Omics: Secretome proteome analysis., Omics: Protein expression by reverse-phase protein arrays., Omics: Genome sequenced., Omics: DNA methylation analysis., Omics: Deep quantitative proteome analysis., Omics: Deep quantitative phosphoproteome analysis., Omics: Deep exome analysis., Omics: CRISPR phenotypic screen., Omics: Array-based CGH., Population: Caucasian., Part of: OCCP ovarian cancer cell line panel., Part of: MD Anderson Cell Lines Project., Part of: COSMIC cell lines project., Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE)., Problematic cell line: Probably misclassified. It is dubious that this cell line originates from an African American 47 year old patient diagnosed with an ovarian clear cell adenocarcinoma. Immunohistochemical and qPCR analysis as well as its mutational profile support an ovarian serous adenocarcinoma origin (PubMed=25049276; DOI=10.26502/ogr072). Furthermore its genome ancestry clearly shows a Caucasian/European decent (PubMed=30894373) which is confirmed by mtDNA haplotyping (DOI=10.26502/ogr072)..
Category: Cancer cell line
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Source: Cellosaurus