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Organism Name
RRID:WB-STRAIN:WBStrain00040824 RRID Copied  
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Organism Information

URL: http://www.wormbase.org/db/get?name=WBStrain00040824

Proper Citation: RRID:WB-STRAIN:WBStrain00040824

Description: Caenorhabditis elegans with name hif-1(ia4) V. from WB.

Species: Caenorhabditis elegans

Synonyms: hif-1(ia4) V.

Notes: Healthy and fertile in standard lab conditions, but unable to adapt to 1% oxygen. When hif-1(+) animals are incubated in1% oxygen, >94% will complete embryogenesis and larval development. In contrast, hif-1(ia4) mutants exhibit 66% embryonic lethality and 9% larval lethality in 1% oxygen. The requirement of hif-1 is alleviated if the oxygen level is increased to 2%. The ia4 mutation is a 1231 bp deletion of the second, third, and fourth exons, which encode much of the helix-loop-helix and PAS domains. Analysis of ESTs suggests that there are at least 4 alternatively spliced hif-1 transcripts. The ia4 deletion introduces a frameshift and a premature stop in the three longest forms.|"Made_by: Jiang/Powell-Coffman"|"Reference WBPaper00059755 added based on published strain data identified by Textpresso literature search."

Affected Gene: WBGene00001851(hif-1)

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Data and Source Information

Source: Integrated Animals

Source Database: WormBase (WB)