vorinostat (CHEBI:45716)

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ChEBI Name	vorinostat

ChEBI ID	CHEBI:45716

Definition	A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C14H20N2O3

Net Charge

Average Mass

264.32020

Monoisotopic Mass

264.14739

InChI

InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)

InChIKey

WAEXFXRVDQXREF-UHFFFAOYSA-N

SMILES

ONC(=O)CCCCCCC(=O)Nc1ccccc1

Roles Classification
Biological Role(s):	EC 3.5.1.98 (histone deacetylase) inhibitor An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98). apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology
Outgoing	vorinostat (CHEBI:45716) has functional parent aniline (CHEBI:17296) vorinostat (CHEBI:45716) has functional parent hydroxylamine (CHEBI:15429) vorinostat (CHEBI:45716) has functional parent suberic acid (CHEBI:9300) vorinostat (CHEBI:45716) has role antineoplastic agent (CHEBI:35610) vorinostat (CHEBI:45716) has role apoptosis inducer (CHEBI:68495) vorinostat (CHEBI:45716) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115) vorinostat (CHEBI:45716) is a dicarboxylic acid diamide (CHEBI:35779) vorinostat (CHEBI:45716) is a hydroxamic acid (CHEBI:24650)

IUPAC Name

N-hydroxy-N'-phenyloctanediamide

Synonyms	Sources
octanedioic acid hydroxyamide phenylamide	ChEBI
SAHA	HMDB
SHH	HMDB
Suberanilohydroxamic acid	HMDB
suberoylanilide hydroxamic acid	ChEBI

Brand Name	Source
Zolinza	KEGG DRUG

Last Modified

22 February 2017