CHEBI:91462 - SU6656

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name SU6656
ChEBI ID CHEBI:91462
Definition A member of the class of oxindoles that is 3-methyleneoxindole in which the hydrogeh at position 5 has been replaced by a dimethylaminosulfonyl group and in which one of the hydrogens of the methylene group has been replaced by a 4,5,6,7-tetrahydro-indol-2-yl group. It is a specific inhibitor of Src family kinase.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:131826
Supplier Information
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Formula C19H21N3O3S
Net Charge 0
Average Mass 371.455
Monoisotopic Mass 371.13036
InChI InChI=1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)
InChIKey LOGJQOUIVKBFGH-UHFFFAOYSA-N
SMILES N1C(C(C2=C1C=CC(=C2)S(N(C)C)(=O)=O)=CC=3NC4=C(C3)CCCC4)=O
Roles Classification
Biological Role(s): EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that specifically blocks the action of non-specific protein-tyrosine kinase (EC 2.7.10.2).
Aurora kinase inhibitor
Any protein kinase inhibitor that inhibits the action of an Aurora kinase (a group of serine/threonine kinases that are essential for cell proliferation).
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing SU6656 (CHEBI:91462) has role antineoplastic agent (CHEBI:35610)
SU6656 (CHEBI:91462) has role Aurora kinase inhibitor (CHEBI:70770)
SU6656 (CHEBI:91462) has role EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor (CHEBI:76617)
SU6656 (CHEBI:91462) is a oxindoles (CHEBI:38459)
SU6656 (CHEBI:91462) is a sulfonamide (CHEBI:35358)
IUPAC Name
N,N-dimethyl-2-oxo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)indoline-5-sulfonamide
Synonyms Sources
SU 6656 ChemIDplus
SU-6656 ChEBI
Manual Xref Database
LSM-1219 LINCS
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Registry Number Type Source
330161-87-0 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
11074000 PubMed citation Europe PMC
15677565 PubMed citation Europe PMC
15985613 PubMed citation Europe PMC
16504759 PubMed citation Europe PMC
22034098 PubMed citation Europe PMC
22102627 PubMed citation Europe PMC
22244830 PubMed citation Europe PMC
23386415 PubMed citation Europe PMC
24093774 PubMed citation Europe PMC
24275091 PubMed citation Europe PMC
Last Modified
25 April 2016