A COMBINE archive is a single file containing the various documents (and in the future, references to documents), necessary for the description of a model and all associated data and procedures. This includes for instance, but not limited to, simulation experiment descriptions, all models needed to run the simulations and associated data files. The archive is encoded using the Open Modeling EXchange format (OMEX).

The Version 1 of the OMEX specification was published on September 15, 2014.

F. T. Bergmann, Adams, R., Moodie, S., Cooper, J., Glont, M., Golebiewski, M., Hucka, M., Laibe, C., Miller, A. K., Nickerson, D. P., Olivier, B. G., Rodriguez, N., Sauro, H. M., Scharm, M., Soiland-Reyes, S., Waltemath, D., Yvon, F., and Le Novère, N. COMBINE archive and OMEX format: one file to share all information to reproduce a modeling project. BMC Systems Biology (2014) 15:369. https://identifiers.org/pubmed/25494900