Jump to: Authorized Access | Attribution | Authorized Requests

Study Description

The Network for Pancreatic Organ Donors with Diabetes (nPOD) is the largest biorepository of human pancreata from organ donors with type 1 diabetes (T1D), maturity-onset diabetes of the young (MODY), cystic fibrosis-related diabetes (CFRD), type 2 diabetes (T2D), gestational diabetes, and islet autoantibody positive (AAb+)/pre-T1D. The mission of the nPOD is to distribute biospecimens and associated de-identified data/metadata to an international researcher network, and to promote the development of new treatments for these diabetes conditions. Here, we describe the release of high-parameter genotyping data for the nPOD cohort. Specifically, 372 subjects were genotyped using a customized precision medicine single nucleotide polymorphism (SNP) microarray (UFDIchip). These data were technically validated using published algorithms to evaluate donor relatedness, ancestry, imputed HLA, and T1D genetic risk score. Additionally, 207 subjects were queried for rare known and novel coding region variants via whole exome sequencing (WES). These data are now publicly available, enabling genotype-selected sample requests and the study of novel genotype : phenotype associations, ultimately to explain diabetes heterogeneity and inform precision medicine strategies to interrupt diabetes pathogenesis.

  • Study Weblinks:
  • Study Design:
    • Collection
  • Study Type:
    • Case-Control
    • Collection
    • Exome Sequencing
    • Genotype
    • Genotype/Expression array
    • Individual-Level Genomic Data
    • Sequencing
  • dbGaP estimated ancestry using GRAF-pop
  • Total number of consented subjects: 412
  • Subject Sample Telemetry Report (SSTR)
Authorized Access
Publicly Available Data (Public ftp)
Study Inclusion/Exclusion Criteria

Inclusion Criteria:

  • Pancreas from donors with type 1 diabetes at any age, and any disease duration. History of dialysis is ruled out on donors with a disease duration greater than 7 years.
  • Pancreas from any donor at 30 years or younger of age, with a BMI of less than 30 where the cause of death was related to Diabetic ketoacidosis (DKA) and/or has an HbA1c of 6.5 or higher.
  • Pancreas from autoantibody positive donors at 30 years or younger of age, with at least 1 or more autoantibodies
Selected Publications
Diseases/Traits Related to Study (MeSH terms)
Links to Related Genes
Authorized Data Access Requests
Study Attribution
  • Principal Investigator
    • Mark A. Atkinson. University of Florida, Gainesville, FL, USA.
  • Co-Investigators
    • Todd M. Brusko. University of Florida, Gainesville, FL, USA.
    • Chester E. Chamberlain. University of California San Francisco, San Francisco, CA, USA.
    • Michael German. University of California San Francisco, San Francisco, CA, USA.
    • Mark S. Anderson. University of California San Francisco, San Francisco, CA, USA.
  • Research Resource
    • RRID:SCR_014641. Network for Pancreatic Organ Donors with Diabetes, University of Florida, Gainesville, FL, USA.
  • Funding Sources
    • 5-SRA-2018-557-Q-R. Network for Pancreatic Organ Donors with Diabetes, University of Florida, Gainesville, FL, USA.
    • 2018PG-T1D053. The Leona M. and Harry B. Helmsley Charitable Trust, New York, NY, USA.
    • G-2108-04793. The Leona M. and Harry B. Helmsley Charitable Trust, New York, NY, USA.
    • P01 AI042288. National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA.
    • UC4 DK108132. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, MD, USA.
    • U01 DK112217. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, MD, USA.