Summary
- Splice variants
- Transcript comparison
- Gene alleles
Sequence
- Secondary Structure
Comparative Genomics
Ontologies
- GO: Biological process
- GO: Molecular function
- GO: Cellular component
Phenotypes
Genetic Variation
Gene expression
Pathway
Molecular interactions
Regulation
External references
Supporting evidence
ID History
- Gene history

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Gene: MTHFR ENSBTAG00000020698

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Description

methylenetetrahydrofolate reductase [Source:VGNC Symbol;Acc:VGNC:31731]

Location

Primary_assembly 16: 41,872,982-41,887,672 forward strand.

ARS-UCD1.3:CM008183.2

About this gene

This gene has 4 transcripts (splice variants), 205 orthologues and 4 paralogues.

Transcripts

Show transcript tableHide transcript table

Transcript ID	Name	bp	Protein	Translation ID	Biotype	UniProt Match	Flags
ENSBTAT00000067196.2	MTHFR-204	2733	696aa	ENSBTAP00000070958.1	Gene/transcipt that contains an open reading frame (ORF).Protein coding	A0A3Q1NGK6	A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. This is defined in detail on http://www.ensembl.org/info/genome/genebuild/canonical.htmlEnsembl Canonical, APPRIS P4: Where the APPRIS core modules are unable to choose a clear principal CDS and there is more than one variant with a distinct (but consecutive) CCDS identifiers, APPRIS selects the longest CCDS isoform as the principal variant. APPRIS is a system to annotate alternatively spliced transcripts based on a range of computational methods to identify the most functionally important transcript(s) of a gene. APPRIS P4,
ENSBTAT00000072127.2	MTHFR-201	2603	655aa	ENSBTAP00000059159.1	Gene/transcipt that contains an open reading frame (ORF).Protein coding	A0A3Q1M8J1	APPRIS ALT1: For genes in which the APPRIS core modules are unable to choose a clear principal isoform, the ALT1 is the candidate transcript(s) models that is conserved in at least three tested species. APPRIS is a system to annotate alternatively spliced transcripts based on a range of computational methods to identify the most functionally important transcript(s) of a gene. APPRIS ALT1,
ENSBTAT00000027586.5	MTHFR-202	2516	626aa	ENSBTAP00000027586.4	Gene/transcipt that contains an open reading frame (ORF).Protein coding	F1MF22	-
ENSBTAT00000072576.2	MTHFR-203	2492	618aa	ENSBTAP00000066765.2	Gene/transcipt that contains an open reading frame (ORF).Protein coding	A0A3Q1M8J1	-

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Summary

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