Summary
- Splice variants
- Transcript comparison
- Gene alleles
Sequence
- Secondary Structure
Comparative Genomics
- Genomic alignments
- Gene tree
- Gene gain/loss tree
- Orthologues
- Paralogues
Ontologies
Phenotypes
Genetic Variation
Gene expression
Pathway
Molecular interactions
Regulation
External references
Supporting evidence
ID History
- Gene history

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Gene: DOT1L ENSDARG00000061992

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Description

DOT1 like histone lysine methyltransferase [Source:HGNC Symbol;Acc:HGNC:24948]

Location

Chromosome 22: 20,782,915-20,838,011 reverse strand.

GRCz11:CM002906.2

About this gene

This gene has 4 transcripts (splice variants), 204 orthologues and is associated with 5 phenotypes.

Transcripts

Show transcript tableHide transcript table

Transcript ID	Name	bp	Protein	Translation ID	Biotype	UniProt Match	Flags
ENSDART00000089076.6	DOT1L-203	4365	1454aa	ENSDARP00000083509.5	Gene/transcipt that contains an open reading frame (ORF).Protein coding	F1Q4W7	A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. This is defined in detail on http://www.ensembl.org/info/genome/genebuild/canonical.htmlEnsembl Canonical,
ENSDART00000186056.1	DOT1L-204	4098	1365aa	ENSDARP00000150531.1	Gene/transcipt that contains an open reading frame (ORF).Protein coding	-	APPRIS P5: Where the APPRIS core modules are unable to choose a clear principal variant and none of the candidate variants are annotated by CCDS, APPRIS selects the longest of the candidate isoforms as the principal variant. APPRIS is a system to annotate alternatively spliced transcripts based on a range of computational methods to identify the most functionally important transcript(s) of a gene. APPRIS P5,
ENSDART00000193778.1	DOT1L-202	4088	1307aa	ENSDARP00000154602.1	Gene/transcipt that contains an open reading frame (ORF).Protein coding	-	-
ENSDART00000142046.2	DOT1L-201	3593	1122aa	ENSDARP00000117281.1	Gene/transcipt that contains an open reading frame (ORF).Protein coding	-	APPRIS ALT2: For genes in which the APPRIS core modules are unable to choose a clear principal isoform, the ALT1 is the candidate transcript(s) models that appear to be conserved in fewer than three tested species. APPRIS is a system to annotate alternatively spliced transcripts based on a range of computational methods to identify the most functionally important transcript(s) of a gene. APPRIS ALT2,

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Summary

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