PKC

An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters. (mesh:D011493)

Cross-references

• SFAM:F0198
• MESH:D011493 - Protein Kinase C
• BEL:PRKC Family
• SIGNOR:SIGNOR-PF53
• ECCODE:2.7.11.13 - Protein kinase C
• IP:IPR012233
• NXP:FA:03065
• NCIT:C17017

Synonyms

Synonym	Reference	Specificity
PKC		Exact
protein kinase C		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:9410	PRKCQ	isa
HGNC:9404	PRKCI	isa
HGNC:9399	PRKCD	isa
HGNC:9408	PRKD3	isa
HGNC:9412	PRKCZ	isa
HGNC:9395	PRKCB	isa
HGNC:9393	PRKCA	isa
HGNC:9402	PRKCG	isa
HGNC:9401	PRKCE	isa
HGNC:9403	PRKCH	isa

Outgoing Relations

None available.