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| Status |
Public on Jun 15, 2020 |
| Title |
Effect of the USP7 inhibitor HBX41,108 on lipopolysaccharide induced gene expression in mouse bone marrow derived macrophages. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
USP7 is a deubiquitinase enzyme that removes polyubiquitin chains form a number of substrates including MDM2, p53 and NF-κB. In this study we assessed the impact of the USP7 inhibitor HBX41,108 on lipopolysaccharide (LPS) induded transcriptional responses in murine bone marrow derived macrophages.
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| Overall design |
Three experimental groups were analysed. Untreated cells, cells stimulated with 100ng/ml LPS for 4 hours and cells pre-treated with 10µM HBX41,108 for 30 mins prior to LPS treatment. Two samples from independent experiments were analysed per group.
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| Contributor(s) |
Carmody RJ, O'Carroll C |
| Citation(s) |
32587091 |
| Submission date |
Apr 27, 2020 |
| Last update date |
Sep 08, 2020 |
| Contact name |
Ruaidhri Carmody |
| E-mail(s) |
ruaidhri.carmody@glasgow.ac.uk
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| Organization name |
University of Glasgow
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| Department |
Institute of Infection, Immunity and Inflammation
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| Lab |
Room B/316
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| Street address |
Sir Graeme Davies Building, 120 University Place
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| City |
Glasgow |
| ZIP/Postal code |
G12 8TA |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL13912 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Feature Number version) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA628734 |
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