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| Status |
Public on Jun 28, 2022 |
| Title |
The Sub-ventricular Zone in Mild Traumatic Brain Injury at Single-cell Resolution |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The subventricular zone (SVZ) is a neurogenetic niche that contributes to homeostasis and repair after brain injury. However, effects of mild traumatic brain injury (mTBI) on genomewide gene expression in the SVZ remain largely unexplored. To address this issue, we investigated the single-nucleus transcriptomic profiles of the SVZ after mTBI. 18 distinct clusters were yielded via unsupervised clustering of the transcriptomic profiles. Cell type specific gene expression responding to mTBI were revealed, some of which were closely associated with pathogenesis post-injury. Furthermore, the diverse cell to cell interaction networks uncovered an array of cellular processes under mTBI. Also, we reported novel lineage trajectories and molecular hallmarks that govern the neurogenesis. Our gene expression atlas provides extensive resources for future researches regarding mTBI induced pathogenesis, its therapeutic interventions or diagnostic tests.
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| Overall design |
SVZ mRNA profiles of 8~10-week old mTBI and Sham mice were generated by scRNA-Seq.
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| Contributor(s) |
Chen X, Liang W, Li M |
| Citation(s) |
36604452, 37783673 |
| Submission date |
Mar 07, 2022 |
| Last update date |
Oct 18, 2023 |
| Contact name |
Weibo Liang |
| E-mail(s) |
liangweibo@gmail.com
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| Organization name |
Sichuan University
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| Street address |
Renmin South Road
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| City |
Chengdu |
| ZIP/Postal code |
610041 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA813564 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE198074_RAW.tar |
117.6 Mb |
(http)(custom) |
TAR (of MTX, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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