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| Status |
Public on Oct 16, 2023 |
| Title |
Spatial transcriptomics of human plastic and non-plastic breast cancer subtypes |
| Organism |
Homo sapiens |
| Experiment type |
Other
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| Summary |
Cellular plasticity is a hallmark of rare Claudin-low (CL) and metaplastic (MBC) breast cancer subtypes, with a documented overlap whose exact extent is yet unknown, and which are associated to resistance and poor survival. We used spatial transcriptomics to further characterise these plastic subtypes, respectively defined molecularly and histopathologically. We identified 3 putative CL tumours (CL-like) and 4 genomically unstable TNBC samples via molecular analyses, combined with 4 MBCs identified by a breast pathologist.
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| Overall design |
Fresh frozen tissue slides analysed using the 10X Genomics Visium spatial transcriptomics technology
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| Contributor(s) |
Martinez P, Ouzounova M, Degletagne C, Muller L, Coutant A |
| Citation(s) |
37813278 |
| Submission date |
Sep 19, 2022 |
| Last update date |
Jan 15, 2024 |
| Contact name |
Pierre Martinez |
| Organization name |
Cancer Research Centre of Lyon
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| Street address |
28 rue Laennec
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| City |
Lyon cedex 08 |
| ZIP/Postal code |
69373 |
| Country |
France |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA882077 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE213688_RAW.tar |
620.2 Mb |
(http)(custom) |
TAR (of CSV, H5, JSON, MTX, PNG, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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