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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Sep 04, 2023 |
| Title |
The hippocampus on Blast-related Traumatic Brain Injury at Single-cell Resolution |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To elucidate molecular features of the cells of Hippocampus, their progeny at each differentiation stage, and surrounding cells in hippocampus under blast wave-induced changes, cells were profiled from matched hippocampus of 3 mice that had received blast injury and 3 controls.Cell type specific gene expression responding to (blast-related traumatic brain injury, bTBI) were revealed, some of which were closely associated with pathogenesis post-injury. Furthermore, the diverse cell to cell interaction networks uncovered an array of cellular processes under bTBI. Our gene expression atlas provides extensive resources for future researches regarding bTBI induced pathogenesis, its therapeutic interventions or diagnostic tests.
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| Overall design |
Hippocampus mRNA profiles of 8~10-week old mTBI and Sham mice were generated by scRNA-Seq.
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| Contributor(s) |
Chen X, Liang W |
| Citation(s) |
37730716 |
| Submission date |
Apr 21, 2023 |
| Last update date |
Sep 25, 2023 |
| Contact name |
Weibo Liang |
| E-mail(s) |
liangweibo@gmail.com
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| Organization name |
Sichuan University
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| Street address |
Renmin South Road
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| City |
Chengdu |
| ZIP/Postal code |
610041 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA958137 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE230253_RAW.tar |
134.3 Mb |
(http)(custom) |
TAR (of MTX, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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