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| Status |
Public on Nov 20, 2019 |
| Title |
Complementary transcriptomic analysis of human medullary thymic epithelial cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Tumor-specific antigens (TSAs) represent ideal targets for cancer immunotherapy, but very few of them have been identified. We are using a proteogenomic approach, combining RNA-Sequencing and mass spectrometry, to discover TSAs. We performed RNA-Sequencing on human medullary thymic epithelial cells (mTECs) to use them as a "normal control" because they express most known genes and orchestrate T cell selection to induce central tolerance to MHC peptides coded by their vast transcriptome.
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| |
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| Overall design |
Transcriptomic analysis of 2 human samples of medullary thymic epithelial cells using Illumina Next seq 500.
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| |
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| Contributor(s) |
Hesnard L, Perreault C |
| Citation(s) |
32345368, 35367648 |
| Submission date |
Mar 05, 2019 |
| Last update date |
Jun 23, 2022 |
| Contact name |
Krystel Vincent |
| E-mail(s) |
krystel.vincent.1@gmail.com
|
| Organization name |
Institute for Research in Immunology and Cancer
|
| Lab |
Immunobiology - Claude Perreault
|
| Street address |
2950, chemin de la Polytechnique, Marcelle-Coutu Pavilion
|
| City |
Montreal |
| State/province |
Quebec |
| ZIP/Postal code |
H3T 1J4 |
| Country |
Canada |
| |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA525591 |
| SRA |
SRP187514 |
