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Status |
Public on Sep 21, 2019 |
Title |
Single-cell Transcriptomic Atlas of the Human Retina Identifies Cell Types Associated with Age-Related Macular Degeneration [Microfluidics] |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
Here we perform massively parallel single-cell RNA sequencing (scRNA-seq) of human retinas using two independent platforms, and report the single-cell transcriptomic atlas of the human retina. Using a multi-resolution network-based analysis, we identify all major retinal cell types, and their corresponding gene expression signatures.
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Overall design |
Three replicates of macula and peripheral retinas.
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Contributor(s) |
Menon M, Mohammadi S, Davila-Velderrain J, Goods BA, Cadwell TD, Xing Y, Rachamimov AS, Shalek AK, Love JC, Kellis K, Hafler BP |
Citation(s) |
- Menon M, Mohammadi S, Davila-Velderrain J, Goods BA et al. Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration. Nat Commun 2019 Oct 25;10(1):4902. PMID: 31653841
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Submission date |
Sep 16, 2019 |
Last update date |
Nov 04, 2019 |
Contact name |
Brian Hafler |
E-mail(s) |
brian.hafler@yale.edu
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Organization name |
Yale School of Medicine
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Street address |
300 George Street
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City |
New Haven |
State/province |
Connecticut |
ZIP/Postal code |
06511 |
Country |
USA |
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Platforms (1) |
GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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Samples (6)
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This SubSeries is part of SuperSeries: |
GSE137847 |
Single-cell Transcriptomic Atlas of the Human Retina Identifies Cell Types Associated with Age-Related Macular Degeneration |
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Relations |
BioProject |
PRJNA565928 |
SRA |
SRP222001 |