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Series GSE137720 Query DataSets for GSE137720
Status Public on Nov 01, 2019
Title Single-cell transcriptomics uncovers zonation of function in the mesenchyme during liver fibrosis
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We profile the transcriptomes of ~30,000 mouse single cells to deconvolve the hepatic mesenchyme in healthy and fibrotic liver at high resolution. We reveal spatial zonation of hepatic stellate cells across the liver lobule, designated portal vein-associated HSC and central vein-associated HSC, and uncover an equivalent functional zonation in a mouse model of centrilobular fibrosis. Our work illustrates the power of single-cell transcriptomics to resolve key collagen-producing cells driving liver fibrosis with high precision.
 
Overall design Single-cell transcriptomic data (10x and SS2) are presented from both healthy mice and following carbon tetrachloride administration (acute (72h) and chronic (6wk) injury models). SS2 data also contains cells harvested from mice 14d post bile duct ligation.
 
Contributor(s) Dobie R, Henderson NC, Wilson-Kanamori JR
Citation(s) 31722201
Submission date Sep 19, 2019
Last update date Nov 25, 2019
Contact name John Roger Wilson-Kanamori
Organization name University of Edinburgh
Department Centre for Inflammation Research
Lab Henderson
Street address 47 Little France Crescent
City Edinburgh
ZIP/Postal code EH16 4TJ
Country United Kingdom
 
Platforms (1)
GPL21103 Illumina HiSeq 4000 (Mus musculus)
Samples (11)
GSM4085623 10x_1
GSM4085624 10x_2
GSM4085625 10x_3
Relations
BioProject PRJNA566389
SRA SRP222529

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Supplementary file Size Download File type/resource
GSE137720_RAW.tar 249.0 Mb (http)(custom) TAR (of CSV, MTX, TAB, TSV)
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Raw data are available in SRA
Processed data provided as supplementary file

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