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Series GSE160667 Query DataSets for GSE160667
Status Public on Nov 03, 2020
Title Enhancer analysis of HER2+ cell lines SKBR-3 (ER-) and BT474m1 (ER+) in response to lapatinib and JQ1 and analysis of FOXA1 chromatin binding in SKBR-3 cells in response to lapatinib and JQ1 and impact of FOXA1 knockdown on BRD4 and MED1
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary SKBR-3 and BT474m1 HER2+ breast cancer cell lines were treated with lapatinib, JQ1, or lapatinib and JQ1 or (for SKBR-3) treated with siRNA pools (non-targeting control or FOXA1) prior to drug treatment before being used for ChIPseq (BRD4, MED1, H3K27Ac, or FOXA1 (for SKBR-3))
 
Overall design 36 experimental samples analyzed, 6 chromatin input control samples
 
Contributor(s) Johnson GL, Angus SP
Citation(s) 33980863
Submission date Nov 02, 2020
Last update date May 10, 2023
Contact name Steven P Angus
E-mail(s) sangus@iu.edu
Phone 317-274-8911
Organization name Indiana University School of Medicine
Department Pediatrics
Street address 1044 W Walnut St
City Indianapolis
State/province IN
ZIP/Postal code 46202
Country USA
 
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (42)
GSM4876635 SKBR3_BRD4_DMSO_24h
GSM4876636 SKBR3_BRD4_300nM_JQ1_24h
GSM4876637 SKBR3_BRD4_300nM_lapatinib_24h
This SubSeries is part of SuperSeries:
GSE160670 Adaptive responses to HER2-directed therapy in breast cancer cell line models
Relations
BioProject PRJNA673895
SRA SRP290849

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE160667_BT474m1-BRD4-MED1-H3K27Ac-Lapatinib-JQ1.xlsx 7.5 Mb (ftp)(http) XLSX
GSE160667_RAW.tar 13.0 Gb (http)(custom) TAR (of BW)
GSE160667_SKBR-3-BRD4-MED1-H3K27Ac-FOXA1-Lapatinib-JQ1.xlsx 7.9 Mb (ftp)(http) XLSX
GSE160667_SKBR-3-BRD4-MED1-siNontargeting-siFOXA1-Lapatinib.xlsx 5.8 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data provided as supplementary file
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