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| Status |
Public on Aug 05, 2021 |
| Title |
scRNA-seq of P20 mouse cochlea |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
ARHL has been thought to result from disordered hair cell function and their loss. ARHL has a significant genetic component. We sought to determine the expression in the cochlea of genes associated with single nucleotide polymorphisms linked to ARHL. We find widespread and varying expression of genes associated with these SNPs in subtypes of cells in the cochlea identified by single-cell RNA sequencing. Genes associated with SNPs with the highest significance were preferentially expressed highly in hair cells while genes associated with SNPs with a lower significance were expressed more universally.
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| Overall design |
Examination of expression patterns of genes expressed in day 20 mouse cochlea.
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| Contributor(s) |
Xue N, Song L, Wu H, Navaratnam D |
| Citation(s) |
34536825 |
| Submission date |
Aug 04, 2021 |
| Last update date |
Nov 04, 2021 |
| Contact name |
Na Xue |
| E-mail(s) |
na.xue1111@gmail.com
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| Organization name |
Shanghai Jiaotong University School of Medicine
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| Department |
Otolaryngology
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| Street address |
Zhizaoju Road 639
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| City |
Shanghai |
| ZIP/Postal code |
200011 |
| Country |
China |
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| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA752099 |
| SRA |
SRP331113 |
