AmiGO 2: Term Details for "pyruvate dehydrogenase (NAD+) activity" (GO:0034604)

Term Information

Accession: GO:0034604
Name: pyruvate dehydrogenase (NAD+) activity
Ontology: molecular_function
Synonyms: None
Alternate IDs: None
Definition: Catalysis of the reaction: pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH. Source: GOC:mah, ISBN:0201090910
Comment: None
History: See term history for GO:0034604 at QuickGO
Chem. react.: has participant NAD(1-); has participant carbon dioxide; has participant NADH(2-); has participant pyruvate; has participant acetyl-CoA(4-); has participant coenzyme A(4-)
Subset: None
Related: Link to all genes and gene products annotated to pyruvate dehydrogenase (NAD+) activity (excluding "regulates").; Link to all direct and indirect annotations to pyruvate dehydrogenase (NAD+) activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for pyruvate dehydrogenase (NAD+) activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0044237 cellular metabolic process
GO:0008152 metabolic process
GO:0008150 biological_process
GO:0006139 nucleobase-containing compound metabolic process
GO:1901360 organic cyclic compound metabolic process
GO:0071704 organic substance metabolic process
GO:0006793 phosphorus metabolic process
GO:0044238 primary metabolic process
GO:0044281 small molecule metabolic process
GO:1901135 carbohydrate derivative metabolic process
GO:0009987 cellular process
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0006753 nucleoside phosphate metabolic process
GO:1901362 organic cyclic compound biosynthetic process
GO:1901576 organic substance biosynthetic process
GO:0019637 organophosphate metabolic process
GO:0006796 phosphate-containing compound metabolic process
GO:0009058 biosynthetic process
GO:1901137 carbohydrate derivative biosynthetic process
GO:0034654 nucleobase-containing compound biosynthetic process
GO:1901293 nucleoside phosphate biosynthetic process
GO:0009117 nucleotide metabolic process
GO:1901564 organonitrogen compound metabolic process
GO:0090407 organophosphate biosynthetic process
GO:0072521 purine-containing compound metabolic process
GO:0019693 ribose phosphate metabolic process
GO:0044249 cellular biosynthetic process
GO:0003674 molecular_function
GO:0033865 nucleoside bisphosphate metabolic process
GO:0009165 nucleotide biosynthetic process
GO:0006082 organic acid metabolic process
GO:1901566 organonitrogen compound biosynthetic process
GO:0006163 purine nucleotide metabolic process
GO:0072522 purine-containing compound biosynthetic process
GO:0009259 ribonucleotide metabolic process
GO:0046390 ribose phosphate biosynthetic process
GO:0006790 sulfur compound metabolic process
GO:0043603 amide metabolic process
GO:0003824 catalytic activity
GO:0033866 nucleoside bisphosphate biosynthetic process
GO:0043436 oxoacid metabolic process
GO:0034032 purine nucleoside bisphosphate metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0009150 purine ribonucleotide metabolic process
GO:0033875 ribonucleoside bisphosphate metabolic process
GO:0009260 ribonucleotide biosynthetic process
GO:0044272 sulfur compound biosynthetic process
GO:0035383 thioester metabolic process
GO:0006637 acyl-CoA metabolic process
GO:0043604 amide biosynthetic process
GO:0019752 carboxylic acid metabolic process
GO:0016491 oxidoreductase activity
GO:0034033 purine nucleoside bisphosphate biosynthetic process
GO:0009152 purine ribonucleotide biosynthetic process
GO:0034030 ribonucleoside bisphosphate biosynthetic process
GO:0035384 thioester biosynthetic process
GO:0006084 acetyl-CoA metabolic process
GO:0071616 acyl-CoA biosynthetic process
GO:0032787 monocarboxylic acid metabolic process
GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors
GO:0006085 acetyl-CoA biosynthetic process
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0004738 pyruvate dehydrogenase activity
GO:0006090 pyruvate metabolic process
GO:0006086 acetyl-CoA biosynthetic process from pyruvate
GO:0034603 pyruvate dehydrogenase [NAD(P)+] activity
GO:0034604 pyruvate dehydrogenase (NAD+) activity
GO:0045254 pyruvate dehydrogenase complex

Parents of pyruvate dehydrogenase (NAD+) activity (GO:0034604)

subject	relation	object
pyruvate dehydrogenase (NAD+) activity	RO:0000057	NAD(1-) (CHEBI:57540)
pyruvate dehydrogenase (NAD+) activity	BFO:0000050	acetyl-CoA biosynthetic process from pyruvate (GO:0006086)
pyruvate dehydrogenase (NAD+) activity	RO:0000057	carbon dioxide (CHEBI:16526)
pyruvate dehydrogenase (NAD+) activity	BFO:0000051	dihydrolipoyl dehydrogenase activity (GO:0004148)
pyruvate dehydrogenase (NAD+) activity	RO:0000057	NADH(2-) (CHEBI:57945)
pyruvate dehydrogenase (NAD+) activity	RO:0000057	pyruvate (CHEBI:15361)
pyruvate dehydrogenase (NAD+) activity	is_a	pyruvate dehydrogenase [NAD(P)+] activity (GO:0034603)
pyruvate dehydrogenase (NAD+) activity	BFO:0000051	dihydrolipoyllysine-residue acetyltransferase activity (GO:0004742)
pyruvate dehydrogenase (NAD+) activity	BFO:0000051	pyruvate dehydrogenase (acetyl-transferring) activity (GO:0004739)
pyruvate dehydrogenase (NAD+) activity	RO:0000057	acetyl-CoA(4-) (CHEBI:57288)
pyruvate dehydrogenase (NAD+) activity	RO:0000057	coenzyme A(4-) (CHEBI:57287)

Children of pyruvate dehydrogenase (NAD+) activity (GO:0034604)

subject	relation	object
pyruvate dehydrogenase complex (GO:0045254)	RO:0002215	pyruvate dehydrogenase (NAD+) activity

EC: 1.2.1.104
KEGG_REACTION: R00209
MetaCyc: PYRUVDEH-RXN
RHEA: 28042