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Symbol report for AMOTL2

HGNC data for AMOTL2

Approved symbol
AMOTL2
Approved name

angiomotin like 2

Locus type
gene with protein product
HGNC ID
HGNC:17812
Symbol status
Approved
Alias symbols
LCCP
Alias names
Leman coiled-coil protein
angiomotin-like protein 2
Chromosomal location
3q22.2
Bos taurus
AMOTL2 VGNC:25872 VGNC
Canis familiaris
AMOTL2 VGNC:37837 VGNC
Equus caballus
AMOTL2 VGNC:15282 VGNC
Felis catus
AMOTL2 VGNC:59771 VGNC
Mus musculus
Amotl2 MGI:1929286 Curated
Pan troglodytes
AMOTL2 VGNC:1731 VGNC
Rattus norvegicus
Amotl2 RGD:70977
Sus scrofa
AMOTL2 VGNC:85285 VGNC
AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion.
Mojallal M et al. Nat Commun 2014 Aug;54557
Mojallal M, Zheng Y, Hultin S, Audebert S, van Harn T, Johnsson P, Lenander C, Fritz N, Mieth C, Corcoran M, Lembo F, Hallström M, Hartman J, Mazure NM, Weide T, Grandér D, Borg JP, Uhlén P, Holmgren L.
Nat Commun 2014 Aug;54557
Abstract: The establishment and maintenance of apical-basal cell polarity is essential for the functionality of glandular epithelia. Cell polarity is often lost in advanced tumours correlating with acquisition of invasive and malignant properties. Despite extensive knowledge regarding the formation and maintenance of polarity, the mechanisms that deregulate polarity in metastasizing cells remain to be fully characterized. Here we show that AmotL2 expression correlates with loss of tissue architecture in tumours from human breast and colon cancer patients. We further show that hypoxic stress results in activation of c-Fos-dependent expression of AmotL2 leading to loss of polarity. c-Fos/hypoxia-induced p60 AmotL2 interacts with the Crb3 and Par3 polarity complexes retaining them in large vesicles and preventing them from reaching the apical membrane. The resulting loss of polarity potentiates the response to invasive cues in vitro and in vivo in mice. These data provide a molecular mechanism how hypoxic stress deregulates cell polarity during tumour progression.