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Symbol report for DIO2

HGNC data for DIO2

Approved symbol
DIO2
Approved name

iodothyronine deiodinase 2

Locus type
gene with protein product
HGNC ID
HGNC:2884
Symbol status
Approved
Previous names
deiodinase, iodothyronine type II
Alias symbols
TXDI2
SelY
SELENOY
Alias names
thyroxine deiodinase, type II
deiodonase-2
deiodinase-2
selenoprotein Y
Chromosomal location
14q31.1
Gene groups
UCSC
Alliance of Genome Resources
Bos taurus
DIO2 VGNC:106710 VGNC
Canis familiaris
DIO2 VGNC:56059 VGNC
Felis catus
DIO2 VGNC:80987 VGNC
Mus musculus
Dio2 MGI:1338833 Curated
Rattus norvegicus
Dio2 RGD:68418
Sus scrofa
DIO2 VGNC:103935 VGNC
IUPHAR/BPS Guide to PHARMACOLOGY
Assignment of type II iodothyronine deiodinase gene (DIO2) to human chromosome band 14q24.2-->q24.3 by in situ hybridization.
Araki O et al. Cytogenet Cell Genet 1999 ;84(1-2)73-74
Araki O, Murakami M, Morimura T, Kamiya Y, Hosoi Y, Kato Y, Mori M.
Cytogenet Cell Genet 1999 ;84(1-2)73-74
Cloning of the mammalian type II iodothyronine deiodinase. A selenoprotein differentially expressed and regulated in human and rat brain and other tissues.
Croteau W et al. J Clin Invest 1996 Jul;98(2)405-417
Croteau W, Davey JC, Galton VA, St Germain DL.
J Clin Invest 1996 Jul;98(2)405-417
Abstract: The deiodination of thyroid hormones in extrathyroidal tissues plays an important role in modulating thyroid hormone action. The type II deiodinase (DII) converts thyroxine to the active hormone 3,5,3'-triiodothyronine, and in the rat is expressed in the brain, pituitary gland, and brown adipose tissue (BAT). Complementary DNAs (cDNAs) for the types I and III deiodinases (DI and DIII, respectively) have been isolated and shown to code for selenoproteins. However, information concerning the structure of the mammalian DII remains limited, and the pattern of its expression in human tissues is undefined. We report herein the identification and characterization of rat and human DII cDNAs. Both code for selenoproteins and exhibit limited regions of homology with the DI and DIII. In the rat pituitary and BAT, DII mRNA levels are altered more than 10-fold by changes in the thyroid hormone status of the animal. Northern analysis of RNA derived from human tissues reveals expression of DII transcripts in heart, skeletal muscle, placenta, fetal brain, and several regions of the adult brain. These studies demonstrate that: (a) the rat and human DII are selenoproteins, (b) DII expression in the rat is regulated, at least in part, at the pretranslational level in some tissues, and (c) DII is likely to be of considerable physiologic importance in thyroid hormone economy in the human fetus and adult.