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Symbol report for DNMT1

Stable symbol

HGNC data for DNMT1

Approved symbol
DNMT1
Approved name

DNA methyltransferase 1

Locus type
gene with protein product
HGNC ID
HGNC:2976
Symbol status
Approved
Previous symbols
DNMT
Previous names
DNA (cytosine-5-)-methyltransferase 1
Alias symbols
MCMT
CXXC9
Chromosomal location
19p13.2
UCSC
Alliance of Genome Resources
Bos taurus
DNMT1 VGNC:28145 VGNC
Canis familiaris
DNMT1 VGNC:108242 VGNC
Equus caballus
DNMT1 VGNC:17255 VGNC
Felis catus
DNMT1 VGNC:61561 VGNC
Macaca mulatta
DNMT1 VGNC:71958 VGNC
Mus musculus
Dnmt1 MGI:94912 Curated
Pan troglodytes
DNMT1 VGNC:10201 VGNC
Rattus norvegicus
Dnmt1 RGD:620979
Sus scrofa
DNMT1 VGNC:87383 VGNC
IUPHAR/BPS Guide to PHARMACOLOGY
Isolation and characterization of the cDNA encoding human DNA methyltransferase.
Yen RW et al. Nucleic Acids Res 1992 May;20(9)2287-2291
Yen RW, Vertino PM, Nelkin BD, Yu JJ, el-Deiry W, Cumaraswamy A, Lennon GG, Trask BJ, Celano P, Baylin SB.
Nucleic Acids Res 1992 May;20(9)2287-2291
Abstract: We have cloned a series of overlapping cDNA clones encoding a 5194 bp transcript for human DNA methyltransferase (DNA MTase). This sequence potentially codes for a protein of 1495 amino acids with a predicted molecular weight of 169 kDa. The human DNA MTase cDNA has eighty percent homology at the nucleotide level, and the predicted protein has seventy-four percent identity at the amino acid level, to the DNA MTase cDNA cloned from mouse cells. Like the murine DNA MTase, the amino terminal two-thirds of the human protein contains a cysteine-rich region suggestive of a metal-binding domain. The carboxy terminal one-third of the protein shows considerable similarity to prokaryotic (cytosine-5)-methyltransferases. The arrangement of multiple motifs conserved in the prokaryotic genes is preserved in the human DNA MTase, including the relative position of a proline-cysteine dipeptide thought to be an essential catalytic site in all (cytosine-5)-methyltransferases. A single 5.2 kb transcript was detected in all human tissues tested, with the highest levels of expression observed in RNA from placenta, brain, heart and lung. DNA MTase cDNA clones were used to screen a chromosome 19 genomic cosmid library. The DNA MTase-positive cosmids which are estimated to span a genomic distance of 93 kb have been localized to 19p13.2-p13.3 by fluorescence in situ hybridization. Isolation of the cDNA for human DNA MTase will allow further study of the regulation of DNA MTase expression, and of the role of this enzyme in establishing DNA methylation patterns in both normal and neoplastic cells.