Record Information |
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Version | 5.0 |
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Status | Detected and Quantified |
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Creation Date | 2006-05-22 14:17:39 UTC |
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Update Date | 2022-03-07 02:49:13 UTC |
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HMDB ID | HMDB0002174 |
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Secondary Accession Numbers | |
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Metabolite Identification |
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Common Name | Cobalamin |
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Description | Cobalamin participates in two enzymatic processes in mammalian cells. In the methionine synthase (EC 2.1.1.13) reaction, homocysteine (HCys) is converted to methionine allowing for the "recycling" of 5-methyl-tetrahydrofolate (THF) to N5,10 methylene-THF which is needed for the de novo synthesis of thymidylic acid and ultimately, for DNA formation. Since conversion of N5,10-methylene-THF to N5-methyl-THF is irreversible, cobalamin deficiency "traps" folic acid as N5-methyl-THF. Concurrently, HCys accumulates while methionine decreases, leading to a decrease in S-adenosylmethionine which further limits N5,10-methylene-THF formation by decreasing the synthesis of formyl-THF ("formate starvation"). Decreased methionine and S-adenosylmethionine may limit many methylation reactions including those involving DNA and myelin basic protein. In the methylmalonyl CoA mutase (EC 5.1.99.1) reaction, methylmalonyl CoA, derived from propionic acid synthesized by intestinal bacteria, is converted to succinyl CoA, a precursor for fatty acid and heme synthesis Thus, cobalamin deficiency results in methylmalonic acid (MMA) accumulation. Cobalamin deficiency causes megaloblastic anemia and neurocognitive abnormalities but effects on immune function and bone formation have also been described. Low serum cobalamin levels increase the risk of osteoporosis. Tests for cobalamin deficiency include measurements of 1) total cobalamin; 2) MMA and HCys, as indices of functional cobalamin deficiency; and 3) holotranscobalamin as a measure of the metabolically active fraction of circulating cobalamin. Each approach has significant limitations. Moreover, since the pathogenesis of neurologic dysfunction in cobalamin deficiency remains unclear, these tests may not be reliable markers of neurocognitive impairment. Subtle cobalamin deficiency, defined as elevated metabolite levels usually in asymptomatic patients with low or normal serum cobalamin values, is prevalent in the elderly and has been associated with food cobalamin malabsorption, a disorder characterized by the inability to release vitamin B12 from food or from its binding proteins. Malabsorption is often unrecognized or not investigated. However, because of the potential seriousness of the complications, particularly neuropsychiatric and hematological investigation of all patients who present with vitamin or nutritional deficiency is required. Classic disorders, such as pernicious anemia, are the cause of cobalamin deficiency in only a limited proportion of elderly patients. Epidemiological studies have shown a prevalence of cobalamin deficiency of around 20% in the elderly population of industrialized countries (between 50% and 60%, depending on the definition of cobalamin deficiency used in the study). New routes of cobalamin administration (oral and nasal) are currently being developed, especially the use of oral cobalamin therapy to treat food-cobalamin malabsorption. (PMID: 16814909 , 17822656 ). |
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Structure | [H][C@]12[C@H](CC(N)=O)[C@@]3(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]4[C@@H](O)[C@H](O[C@@H]4CO)N4C=[N+](C5=CC(C)=C(C)C=C45)[Co--]456N1C3=C(C)C1=[N+]4C(=CC3=[N+]5C(=C(C)C4=[N+]6[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]3CCC(N)=O)C(C)(C)[C@@H]1CCC(N)=O InChI=1S/C62H90N13O14P.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);/q;+3/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;/m1./s1 |
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Synonyms | Value | Source |
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alpha-(5,6-Dimethylbenzimidazolyl)cobamide | ChEBI | Cbl | ChEBI | Cobalamin (III) | ChEBI | Cobalamin(1+) | ChEBI | Cobalamin(III) | ChEBI | a-(5,6-Dimethylbenzimidazolyl)cobamide | Generator | Α-(5,6-dimethylbenzimidazolyl)cobamide | Generator | 5,6-Dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole | HMDB | 5,6-Dimethyl-1-a-D-ribofuranosylbenzimidazole | HMDB | 5,6-Dimethyl-1-alpha-delta-ribofuranosyl-1H-benzimidazole | HMDB | 5,6-Dimethyl-1-alpha-delta-ribofuranosylbenzimidazole | HMDB | Cob(III)alamin | HMDB | Cobalamine | HMDB | Cobinamide ion(1+) dihydrogen phosphate (ester) inner salt 3'-ester | HMDB | Cobinamide ion(1+) dihydrogen phosphate (ester) inner salt 3'-ester with 5,6-dimethyl-1-alpha-delta-ribofuranosyl-1H-benzimidazole | HMDB | Hydroxomin | HMDB | Rubivite | HMDB | Rubratope-57 | HMDB | Rubratope-60 | HMDB | Ruvite | HMDB | Vitamin b12 | HMDB | b 12, Vitamin | HMDB | b12, Vitamin | HMDB | Cobalamins | HMDB | Cyanocobalamin | HMDB | Eritron | HMDB | Vitamin b 12 | HMDB |
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Chemical Formula | C62H88CoN13O14P |
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Average Molecular Weight | 1329.369 |
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Monoisotopic Molecular Weight | 1328.563777 |
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IUPAC Name | (10S,12R,13S,17R,23R,24R,25R,30S,35S,36S,40S,41S,42R,46R)-30,35,40-tris(2-carbamoylethyl)-24,36,41-tris(carbamoylmethyl)-46-hydroxy-12-(hydroxymethyl)-5,6,17,23,28,31,31,36,38,41,42-undecamethyl-15,20-dioxo-11,14,16-trioxa-2lambda5,9,19,26,43lambda5,44lambda5,45lambda5-heptaaza-15lambda5-phospha-1-cobaltadodecacyclo[27.14.1.1^{1,34}.1^{2,9}.1^{10,13}.0^{1,26}.0^{3,8}.0^{23,27}.0^{25,42}.0^{32,44}.0^{39,43}.0^{37,45}]heptatetraconta-2(47),3,5,7,27,29(44),32,34(45),37,39(43)-decaene-2,43,44,45-tetrakis(ylium)-1,1-diuid-15-olate |
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Traditional Name | (10S,12R,13S,17R,23R,24R,25R,30S,35S,36S,40S,41S,42R,46R)-30,35,40-tris(2-carbamoylethyl)-24,36,41-tris(carbamoylmethyl)-46-hydroxy-12-(hydroxymethyl)-5,6,17,23,28,31,31,36,38,41,42-undecamethyl-15,20-dioxo-11,14,16-trioxa-2lambda5,9,19,26,43lambda5,44lambda5,45lambda5-heptaaza-15lambda5-phospha-1-cobaltadodecacyclo[27.14.1.1^{1,34}.1^{2,9}.1^{10,13}.0^{1,26}.0^{3,8}.0^{23,27}.0^{25,42}.0^{32,44}.0^{39,43}.0^{37,45}]heptatetraconta-2(47),3,5,7,27,29(44),32,34(45),37,39(43)-decaene-2,43,44,45-tetrakis(ylium)-1,1-diuid-15-olate |
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CAS Registry Number | 13408-78-1 |
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SMILES | [H][C@]12[C@H](CC(N)=O)[C@@]3(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]4[C@@H](O)[C@H](O[C@@H]4CO)N4C=[N+](C5=CC(C)=C(C)C=C45)[Co--]456N1C3=C(C)C1=[N+]4C(=CC3=[N+]5C(=C(C)C4=[N+]6[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]3CCC(N)=O)C(C)(C)[C@@H]1CCC(N)=O |
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InChI Identifier | InChI=1S/C62H90N13O14P.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);/q;+3/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;/m1./s1 |
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InChI Key | NSLAUEAQDBERRV-DSRCUDDDSA-L |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as cobalamin derivatives. These are organic compounds containing a corrin ring, a cobalt atom, an a nucleotide moiety. Cobalamin Derivatives are actually derived from vitamin B12. |
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Kingdom | Organic compounds |
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Super Class | Organoheterocyclic compounds |
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Class | Tetrapyrroles and derivatives |
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Sub Class | Corrinoids |
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Direct Parent | Cobalamin derivatives |
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Alternative Parents | |
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Substituents | - Cobalamin
- Metallotetrapyrrole skeleton
- 1-ribofuranosylbenzimidazole
- Pentose phosphate
- N-glycosyl compound
- Glycosyl compound
- Monosaccharide phosphate
- Pentose monosaccharide
- Benzimidazole
- Phosphoethanolamine
- Dialkyl phosphate
- Monosaccharide
- N-substituted imidazole
- Organic phosphoric acid derivative
- Phosphoric acid ester
- Alkyl phosphate
- Benzenoid
- Fatty amide
- Fatty acyl
- Pyrroline
- Pyrrolidine
- Imidazole
- Azole
- Tetrahydrofuran
- Heteroaromatic compound
- Secondary carboxylic acid amide
- Secondary alcohol
- Primary carboxylic acid amide
- Carboxamide group
- Ketimine
- Oxacycle
- Azacycle
- Organic transition metal salt
- Carbene-type 1,3-dipolar compound
- Carboxylic acid derivative
- Alcohol
- Organic nitrogen compound
- Organonitrogen compound
- Organooxygen compound
- Imine
- Primary alcohol
- Organic salt
- Organic cobalt salt
- Hydrocarbon derivative
- Organic oxide
- Organopnictogen compound
- Carbonyl group
- Organic oxygen compound
- Organic cation
- Aromatic heteropolycyclic compound
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Molecular Framework | Aromatic heteropolycyclic compounds |
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External Descriptors | |
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Ontology |
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Physiological effect | Not Available |
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Disposition | Biological locationSourceExogenous- Exogenous (HMDB: HMDB0002174)
FoodBeverageHerb and spiceNutAquatic originFruitVegetableBaby foodAnimal originCereal and cereal productBaking goodPulseSoyUnclassified food or beverageDishFat and oilMilk and milk productOther milk productFermented milk productUnfermented milk- Milk (Other mammals) (FooDB: FOOD00690)
- Milk (Human) (FooDB: FOOD00666)
- Milk (Cow) (FooDB: FOOD00618)
- Cow milk, pasteurized, vitamin A + D added, 0% fat (FooDB: FOOD00889)
- Cow milk, pasteurized, vitamin A + D added, 1% fat (FooDB: FOOD00890)
- Cow milk, pasteurized, vitamin A + D added, 2% fat (FooDB: FOOD00891)
- Cow milk, pasteurized, vitamin D added, 3.25% fat (FooDB: FOOD00892)
Fermented milk GourdConfectioneryCocoa and cocoa productCoffee and coffee productSnackEggTea
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Process | |
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Role | |
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Physical Properties |
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State | Solid |
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Experimental Molecular Properties | Property | Value | Reference |
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Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Experimental Chromatographic Properties | Not Available |
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Predicted Molecular Properties | | Show more...
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Predicted Chromatographic Properties | Predicted Kovats Retention IndicesNot Available |
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Spectra |
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| MS/MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Cobalamin 10V, Positive-QTOF | splash10-0002-2031000095-b9bf39827ae83761ccb6 | 2018-11-27 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Cobalamin 20V, Positive-QTOF | splash10-0a4j-2393000063-424c175511ddc5e4d2fe | 2018-11-27 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Cobalamin 40V, Positive-QTOF | splash10-0a4i-9740000051-7d6903b2dd8881008344 | 2018-11-27 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Cobalamin 10V, Positive-QTOF | splash10-03di-0059000000-dec49680276dd7d5a080 | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Cobalamin 20V, Positive-QTOF | splash10-0i00-0092000000-2a13d3fd995ffd79ff7f | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Cobalamin 40V, Positive-QTOF | splash10-004i-3191000000-20e008a7f11bbe916e61 | 2021-09-22 | Wishart Lab | View Spectrum |
NMR SpectraSpectrum Type | Description | Deposition Date | Source | View |
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Predicted 1D NMR | 13C NMR Spectrum (1D, 100 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 100 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 1000 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 1000 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 200 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 200 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 300 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 300 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 400 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 400 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 500 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 500 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 600 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 600 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 700 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 700 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 800 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 800 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 900 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 900 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum |
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Biological Properties |
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Cellular Locations | |
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Biospecimen Locations | - Blood
- Cerebrospinal Fluid (CSF)
- Urine
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Tissue Locations | - Erythrocyte
- Fibroblasts
- Intestine
- Liver
- Neuron
- Placenta
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Pathways | |
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Normal Concentrations |
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Blood | Detected and Quantified | 0.000195-0.00119 uM | Infant (5 days - <1 year old) | Both | Normal | | details | Blood | Detected and Quantified | 0.00021-0.0012 uM | Children (1 - <9 years old) | Both | Normal | | details | Blood | Detected and Quantified | 0.00019-0.00085 uM | Children (9 - <14 years old) | Both | Normal | | details | Blood | Detected and Quantified | 0.00018-0.00067 uM | Adolescent (14 - <17 years old) | Both | Normal | | details | Blood | Detected and Quantified | 0.000153-0.00061 uM | Adolescent (17 - <19 years old) | Both | Normal | | details | Blood | Detected and Quantified | >0.000198 uM | Not Specified | Not Specified | Normal | | details | Blood | Detected and Quantified | 0.000316 +/- 0.000128 uM | Adult (>18 years old) | Both | Normal | | details | Blood | Detected and Quantified | 0.000316 +/- 0.00008790 uM | Adult (>18 years old) | Both | Normal | | details | Blood | Detected and Quantified | 0.000319 +/- 0.000168 uM | Adult (>18 years old) | Both | Normal | | details | Blood | Detected and Quantified | 0.000320 +/- 0.000192 uM | Adult (>18 years old) | Both | Normal | | details | Blood | Detected and Quantified | 0.000419 +/- 0.000163 uM | Adult (>18 years old) | Both | Normal | | details | Blood | Detected and Quantified | 0.000431 +/- 0.000183 uM | Adult (>18 years old) | Both | Normal | | details | Blood | Detected and Quantified | 0.000457 +/- 0.000167 uM | Adult (>18 years old) | Both | Normal | | details | Blood | Detected and Quantified | 0.000459 +/- 0.000289 uM | Adult (>18 years old) | Both | Normal | | details | Blood | Detected and Quantified | 0.000469 +/- 0.000362 uM | Adult (>18 years old) | Both | Normal | | details | Blood | Detected and Quantified | 0.000498 +/- 0.000454 uM | Adult (>18 years old) | Both | Normal | | details | Blood | Detected and Quantified | 0.000535 +/- 0.000635 uM | Adult (>18 years old) | Both | Normal | | details | Blood | Detected and Quantified | 0.000582 +/- 0.000654 uM | Adult (>18 years old) | Both | Normal | | details | Blood | Detected and Quantified | 0.000245 uM | Adult (>18 years old) | Female | Normal | | details | Blood | Detected and Quantified | 0.000281 uM | Adolescent (13-18 years old) | Female | Normal | | details | Blood | Detected and Quantified | 0.000349 uM | Adolescent (13-18 years old) | Female | Normal | | details | Blood | Detected and Quantified | 0.000407 uM | Adult (>18 years old) | Female | Normal | | details | Blood | Detected and Quantified | 0.000534 uM | Adult (>18 years old) | Female | Normal | | details | Blood | Detected and Quantified | 0.000276 +/- 0.000137 uM | Adult (>18 years old) | Female | Normal | | details | Blood | Detected and Quantified | 0.000294 +/- 0.000150 uM | Adult (>18 years old) | Female | Normal | | details | Blood | Detected and Quantified | 0.000312 uM | Adult (>18 years old) | Male | Normal | | details | Blood | Detected and Quantified | 0.000315 uM | Adult (>18 years old) | Male | Normal | | details | Blood | Detected and Quantified | 0.000318 uM | Adult (>18 years old) | Male | Normal | | details | Blood | Detected and Quantified | 0.000321 uM | Adult (>18 years old) | Male | Normal | | details | Blood | Detected and Quantified | 0.000346 uM | Adult (>18 years old) | Male | Normal | | details | Blood | Detected and Quantified | 0.000356 uM | Adult (>18 years old) | Male | Normal | | details | Blood | Detected and Quantified | 0.000358 uM | Adult (>18 years old) | Male | Normal | | details | Blood | Detected and Quantified | 0.000363 uM | Adult (>18 years old) | Male | Normal | | details | Blood | Detected and Quantified | 0.00038 uM | Adult (>18 years old) | Male | Normal | | details | Blood | Detected and Quantified | 0.000244 +/- 0.000132 uM | Adult (>18 years old) | Male | Normal | | details | Blood | Detected and Quantified | 0.000280 +/- 0.000151 uM | Adult (>18 years old) | Male | Normal | | details | Blood | Detected and Quantified | 0.000479 +/- 0.000234 uM | Adult (>18 years old) | Male | Normal | | details | Blood | Detected and Quantified | 0.000148-0.000627 uM | Infant (0-1 year old) | Not Specified | Normal | | details | Blood | Detected and Quantified | 0.0002 (0.00012 - 0.00026) uM | Infant (0-1 year old) | Not Specified | Normal | | details | Blood | Detected and Quantified | 0.0003 (0.00046-0.0023) uM | Infant (0-1 year old) | Not Specified | Normal | | details | Blood | Detected and Quantified | 0.0003 ( 0.00015 - 0.00055) uM | Adult (>18 years old) | Female | Normal | | details | Blood | Detected and Quantified | 0.0002 (0.0001 - 0.00033) uM | Adult (>18 years old) | Female | Normal | | details | Cerebrospinal Fluid (CSF) | Detected and Quantified | 0.00001581 +/- 0.000003462 uM | Not Specified | Not Specified | Normal | | details | Cerebrospinal Fluid (CSF) | Detected and Quantified | 0.00001-0.00004 uM | Newborn (0-30 days old) | Not Specified | Normal | | details | Urine | Detected and Quantified | 0.000001733 +/- 0.000001 umol/mmol creatinine | Children (1 - 13 years old) | Both | Normal | | details | Urine | Detected and Quantified | 0.000001867 +/- 0.000001200 umol/mmol creatinine | Adult (>18 years old) | Both | Normal | | details |
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Abnormal Concentrations |
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Blood | Detected and Quantified | 37.612-60.180 uM | Children (1-13 years old) | Male | Megaloblastic anemia 1 | | details | Blood | Detected and Quantified | 0.000139 uM | Infant (0-1 year old) | Female | Pyroglutamic aciduria | | details | Blood | Detected and Quantified | 0.000202 +/- 0.00007447 uM | Adult (>18 years old) | Female | Pregnancy | | details | Blood | Detected and Quantified | 0.000463-0.000639 uM | Newborn (0-30 days old) | Female | Transcobalamin II deficiency | | details | Blood | Detected and Quantified | 0.000116 uM | Infant (0-1 year old) | Female | Cobalamin F disease (cblF) | | details | Cerebrospinal Fluid (CSF) | Detected and Quantified | 0.00002100 +/- 0.000007301 uM | Adult (>18 years old) | Both | Relapse-Remitting Multiple Sclerosis | | details | Cerebrospinal Fluid (CSF) | Detected and Quantified | 0.00001912 +/- 0.0000060000 uM | Adult (>18 years old) | Both | Secondary-Progressive Multiple Sclerosis | | details |
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Associated Disorders and Diseases |
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Disease References | Pregnancy |
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- Shiraishi M, Haruna M, Matsuzaki M, Murayama R, Sasaki S, Murashima S: Validity and reproducibility of folate and vitamin B(12) intakes estimated from a self-administered diet history questionnaire in Japanese pregnant women. Nutr J. 2012 Mar 15;11:15. doi: 10.1186/1475-2891-11-15. [PubMed:22420377 ]
| Transcobalamin II deficiency |
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- Bibi H, Gelman-Kohan Z, Baumgartner ER, Rosenblatt DS: Transcobalamin II deficiency with methylmalonic aciduria in three sisters. J Inherit Metab Dis. 1999 Oct;22(7):765-72. [PubMed:10518276 ]
| Cobalamin F disease (cblF) |
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- Alfadhel M, Lillquist YP, Davis C, Junker AK, Stockler-Ipsiroglu S: Eighteen-year follow-up of a patient with cobalamin F disease (cblF): report and review. Am J Med Genet A. 2011 Oct;155A(10):2571-7. doi: 10.1002/ajmg.a.34220. Epub 2011 Sep 9. [PubMed:21910240 ]
| Megaloblastic anemia 1 |
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- WATERS AH, MURPHY ME: Familial juvenile pernicious anaemia: a study of the hereditary basis of pernicious anaemia. Br J Haematol. 1963 Jan;9:1-12. [PubMed:13999146 ]
| Multiple sclerosis |
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- Scalabrino G, Galimberti D, Mutti E, Scalabrini D, Veber D, De Riz M, Bamonti F, Capello E, Mancardi GL, Scarpini E: Loss of epidermal growth factor regulation by cobalamin in multiple sclerosis. Brain Res. 2010 May 28;1333:64-71. doi: 10.1016/j.brainres.2010.03.073. Epub 2010 Mar 27. [PubMed:20347721 ]
| Cystic fibrosis |
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- Scalabrino G, Galimberti D, Mutti E, Scalabrini D, Veber D, De Riz M, Bamonti F, Capello E, Mancardi GL, Scarpini E: Loss of epidermal growth factor regulation by cobalamin in multiple sclerosis. Brain Res. 2010 May 28;1333:64-71. doi: 10.1016/j.brainres.2010.03.073. Epub 2010 Mar 27. [PubMed:20347721 ]
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Associated OMIM IDs | - 275350 (Transcobalamin II deficiency)
- 277380 (Cobalamin F disease (cblF))
- 261100 (Megaloblastic anemia 1)
- 126200 (Multiple sclerosis)
- 219700 (Cystic fibrosis)
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External Links |
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DrugBank ID | Not Available |
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Phenol Explorer Compound ID | Not Available |
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FooDB ID | FDB022886 |
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KNApSAcK ID | C00001534 |
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Chemspider ID | 5256728 |
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KEGG Compound ID | C05776 |
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BioCyc ID | Not Available |
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BiGG ID | Not Available |
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Wikipedia Link | Cobalamin |
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METLIN ID | 6527 |
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PubChem Compound | 6857388 |
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PDB ID | Not Available |
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ChEBI ID | 28911 |
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Food Biomarker Ontology | Not Available |
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VMH ID | Not Available |
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MarkerDB ID | MDB00000382 |
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Good Scents ID | Not Available |
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References |
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Synthesis Reference | Abou-Zeid, A. A.; El-Sherbeeny, M. R. Production of cobalamin by Streptomyces olivaceus. Indian Journal of Technology (1976), 14(7), 357-9. |
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Material Safety Data Sheet (MSDS) | Not Available |
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General References | - Fyfe JC, Madsen M, Hojrup P, Christensen EI, Tanner SM, de la Chapelle A, He Q, Moestrup SK: The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless. Blood. 2004 Mar 1;103(5):1573-9. Epub 2003 Oct 23. [PubMed:14576052 ]
- Urban G, Pietrzik K, Hotzel D: [Radiological investigations of cobalamin supply with regard to folate status (author's transl)]. Int J Vitam Nutr Res. 1981;51(2):124-31. [PubMed:7287335 ]
- Kanazawa S, Herbert V: Total corrinoid, cobalamin (vitamin B12), and cobalamin analogue levels may be normal in serum despite cobalamin in liver depletion in patients with alcoholism. Lab Invest. 1985 Jul;53(1):108-10. [PubMed:4010227 ]
- Minato H, Inada A, Kozaka S: [The effect of the external biliary diversion on cobalamin functions]. Nihon Geka Gakkai Zasshi. 1995 Oct;96(10):695-702. [PubMed:8538588 ]
- Hansen PK, Byskov J, Gimsing P, Hippe E, Ladefoged K: Cobalamin absorption determined by the stool spot test. Reliability in patients with uremia or disorders of the ileum. Scand J Gastroenterol. 1986 Apr;21(3):341-7. [PubMed:3086965 ]
- Ermens AA, Vlasveld LT, van Marion-Kievit JA, Lensen CJ, Lindemans J: [The significance of an elevated cobalamin concentration in the blood]. Ned Tijdschr Geneeskd. 2002 Mar 9;146(10):459-64. [PubMed:11913109 ]
- Lott WB, Takyar SS, Tuppen J, Crawford DH, Harrison M, Sloots TP, Gowans EJ: Vitamin B12 and hepatitis C: molecular biology and human pathology. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):4916-21. Epub 2001 Apr 10. [PubMed:11296247 ]
- Haltmayer M, Mueller T, Poelz W: Erythrocyte mean cellular volume and its relation to serum homocysteine, vitamin B12 and folate. Acta Med Austriaca. 2002;29(2):57-60. [PubMed:12050947 ]
- Baker H, Leevy CB, DeAngelis B, Frank O, Baker ER: Cobalamin (vitamin B12) and holotranscobalamin changes in plasma and liver tissue in alcoholics with liver disease. J Am Coll Nutr. 1998 Jun;17(3):235-8. [PubMed:9627908 ]
- Watkins D, Matiaszuk N, Rosenblatt DS: Complementation studies in the cblA class of inborn error of cobalamin metabolism: evidence for interallelic complementation and for a new complementation class (cblH). J Med Genet. 2000 Jul;37(7):510-3. [PubMed:10882753 ]
- Ermens AA, Vlasveld LT, Lindemans J: Significance of elevated cobalamin (vitamin B12) levels in blood. Clin Biochem. 2003 Nov;36(8):585-90. [PubMed:14636871 ]
- Solomon LR: Disorders of cobalamin (vitamin B12) metabolism: emerging concepts in pathophysiology, diagnosis and treatment. Blood Rev. 2007 May;21(3):113-30. Epub 2006 Jul 11. [PubMed:16814909 ]
- Andres E, Vidal-Alaball J, Federici L, Loukili NH, Zimmer J, Kaltenbach G: Clinical aspects of cobalamin deficiency in elderly patients. Epidemiology, causes, clinical manifestations, and treatment with special focus on oral cobalamin therapy. Eur J Intern Med. 2007 Oct;18(6):456-62. Epub 2007 Jul 12. [PubMed:17822656 ]
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