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Record Information

Version

5.0

Status

Detected and Quantified

Creation Date

2006-05-22 14:17:50 UTC

Update Date

2022-03-07 02:49:15 UTC

HMDB ID

HMDB0002369

Secondary Accession Numbers

HMDB02369

Metabolite Identification

Common Name

9-cis-Retinoic acid

Description

9-cis-Retinoic acid is an active retinoid that regulates expression of retinoid responsive genes, serving as a ligand for two classes of ligand-dependent transcription factors: the retinoic acid receptors and retinoid X receptors. Retinoids (vitamin A and its analogs) are essential dietary substances that are needed by mammals for reproduction, normal embryogenesis, growth, vision, and maintaining normal cellular differentiation and the integrity of the immune system. Within cells, retinoids regulate gene transcription acting through ligand-dependent transcription factors, the retinoic acid receptors (RARs), and the retinoid X receptors (RXRs). all-trans-Retinoic acid binds only to RARs with high affinity, whereas its 9-cis isomer binds with high affinity to both RARs and RXRs. The actions of all-trans- and 9-cis-retinoic acid in regulating cellular responses are distinct and not interchangeable (PMID: 9115228 ).

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

HMDB0002369
     RDKit          3D
9-cis-Retinoic acid
 50 50  0  0  0  0  0  0  0  0999 V2000
   -2.9590    3.2142    1.8094 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1409    2.2653    0.6613 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1341    1.4348    0.4076 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9297    1.5138    1.2663 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1595    0.8158    1.1915 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3135    0.9340    2.0643 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3274    1.9377    3.2033 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3660    0.1763    1.8927 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4811   -0.8172    0.8568 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5806   -1.5569    0.7313 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7097   -2.5534   -0.2991 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6691   -2.8481   -1.2997 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8477   -3.2670   -0.3703 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1150   -4.2994   -1.3508 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3071   -4.6468   -2.2477 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3300   -4.9906   -1.3548 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2057    0.4627   -0.6811 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2702    0.8780   -1.8069 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8355   -0.9597   -0.2560 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6160    0.3419   -1.2211 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3085    1.6397   -1.4293 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3915    2.3457   -0.0779 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1213    3.8963    1.6635 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8832    3.7852    1.9280 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8587    2.5823    2.7295 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9689    2.2565    2.0583 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2220    0.0914    0.4079 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2312    2.5653    2.9718 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6188    1.4052    4.1520 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4256    2.5113    3.2915 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2243    0.3097    2.5957 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6723   -0.9726    0.1735 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3680   -1.3634    1.4458 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1551   -2.6910   -2.3116 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8256   -2.1637   -1.3012 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3602   -3.9194   -1.2937 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6052   -3.0140    0.3927 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.1785   -4.6017   -1.7484 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8467    1.6331   -2.4092 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3197    1.2974   -1.4470 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0441    0.0209   -2.4745 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7452   -1.6013   -0.4998 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7163   -1.0768    0.8228 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0165   -1.3067   -0.8900 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1776   -0.2249   -0.4372 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5553   -0.2867   -2.1381 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7662    2.2460   -2.1722 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3358    1.4642   -1.8146 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1688    1.7650    0.4917 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7780    3.3715   -0.2626 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  6  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 11 13  2  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
  3 17  1  0
 17 18  1  0
 17 19  1  0
 17 20  1  0
 20 21  1  0
 21 22  1  0
 22  2  1  0
  1 23  1  0
  1 24  1  0
  1 25  1  0
  4 26  1  0
  5 27  1  0
  7 28  1  0
  7 29  1  0
  7 30  1  0
  8 31  1  0
  9 32  1  0
 10 33  1  0
 12 34  1  0
 12 35  1  0
 12 36  1  0
 13 37  1  0
 16 38  1  0
 18 39  1  0
 18 40  1  0
 18 41  1  0
 19 42  1  0
 19 43  1  0
 19 44  1  0
 20 45  1  0
 20 46  1  0
 21 47  1  0
 21 48  1  0
 22 49  1  0
 22 50  1  0
M  END

  Mrv1652305281819482D          

 22 22  0  0  0  0            999 V2000
   -3.8707    0.3187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8707   -0.5063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1563   -0.9188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7396    1.3146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1563    0.7312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5729    1.3146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4418   -0.5063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7273   -0.9188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4418    0.3187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7273    0.7312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0128    0.3187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4161    0.3187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4161   -0.5062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1306   -0.9187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8449   -2.1562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1306   -1.7437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4161   -2.1562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2984    0.7312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2984    1.5563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1306   -3.3937    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8449   -2.9812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5595   -3.3937    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  5  1  1  0  0  0  0
  5  9  1  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  7  1  0  0  0  0
  7  9  2  0  0  0  0
  5  4  1  0  0  0  0
  5  6  1  0  0  0  0
  7  8  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 18  1  0  0  0  0
 18 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 16  1  0  0  0  0
 16 15  2  0  0  0  0
 15 21  1  0  0  0  0
 16 17  1  0  0  0  0
 18 19  1  0  0  0  0
 21 20  2  0  0  0  0
 21 22  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0002369

> <DATABASE_NAME>
hmdb

> <SMILES>
C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+

> <INCHI_KEY>
SHGAZHPCJJPHSC-ZVCIMWCZSA-N

> <FORMULA>
C20H28O2

> <MOLECULAR_WEIGHT>
300.4351

> <EXACT_MASS>
300.20893014

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
50

> <JCHEM_AVERAGE_POLARIZABILITY>
35.88530022493456

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid

> <ALOGPS_LOGP>
5.66

> <JCHEM_LOGP>
5.014367711

> <ALOGPS_LOGS>
-4.80

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.996647744997455

> <JCHEM_POLAR_SURFACE_AREA>
37.3

> <JCHEM_REFRACTIVITY>
97.79079999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
4.77e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
alitretinoin

> <JCHEM_VEBER_RULE>
1

$$$$

HMDB0002369
     RDKit          3D
9-cis-Retinoic acid
 50 50  0  0  0  0  0  0  0  0999 V2000
   -2.9590    3.2142    1.8094 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1409    2.2653    0.6613 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1341    1.4348    0.4076 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9297    1.5138    1.2663 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1595    0.8158    1.1915 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3135    0.9340    2.0643 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3274    1.9377    3.2033 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3660    0.1763    1.8927 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4811   -0.8172    0.8568 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5806   -1.5569    0.7313 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7097   -2.5534   -0.2991 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6691   -2.8481   -1.2997 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8477   -3.2670   -0.3703 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1150   -4.2994   -1.3508 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3071   -4.6468   -2.2477 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3300   -4.9906   -1.3548 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2057    0.4627   -0.6811 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2702    0.8780   -1.8069 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8355   -0.9597   -0.2560 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6160    0.3419   -1.2211 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3085    1.6397   -1.4293 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3915    2.3457   -0.0779 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1213    3.8963    1.6635 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8832    3.7852    1.9280 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8587    2.5823    2.7295 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9689    2.2565    2.0583 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2220    0.0914    0.4079 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2312    2.5653    2.9718 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6188    1.4052    4.1520 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4256    2.5113    3.2915 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2243    0.3097    2.5957 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6723   -0.9726    0.1735 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3680   -1.3634    1.4458 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1551   -2.6910   -2.3116 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8256   -2.1637   -1.3012 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3602   -3.9194   -1.2937 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6052   -3.0140    0.3927 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.1785   -4.6017   -1.7484 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8467    1.6331   -2.4092 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3197    1.2974   -1.4470 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0441    0.0209   -2.4745 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7452   -1.6013   -0.4998 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7163   -1.0768    0.8228 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0165   -1.3067   -0.8900 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1776   -0.2249   -0.4372 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5553   -0.2867   -2.1381 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7662    2.2460   -2.1722 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3358    1.4642   -1.8146 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1688    1.7650    0.4917 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7780    3.3715   -0.2626 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  6  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 11 13  2  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
  3 17  1  0
 17 18  1  0
 17 19  1  0
 17 20  1  0
 20 21  1  0
 21 22  1  0
 22  2  1  0
  1 23  1  0
  1 24  1  0
  1 25  1  0
  4 26  1  0
  5 27  1  0
  7 28  1  0
  7 29  1  0
  7 30  1  0
  8 31  1  0
  9 32  1  0
 10 33  1  0
 12 34  1  0
 12 35  1  0
 12 36  1  0
 13 37  1  0
 16 38  1  0
 18 39  1  0
 18 40  1  0
 18 41  1  0
 19 42  1  0
 19 43  1  0
 19 44  1  0
 20 45  1  0
 20 46  1  0
 21 47  1  0
 21 48  1  0
 22 49  1  0
 22 50  1  0
M  END

HEADER    PROTEIN                                 28-MAY-18   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   28-MAY-18         0                                  
HETATM    1  C   UNK     0      -7.225   0.595   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -7.225  -0.945   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -5.892  -1.715   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -6.981   2.454   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -5.892   1.365   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -4.803   2.454   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -4.558  -0.945   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -3.224  -1.715   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -4.558   0.595   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      -3.224   1.365   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      -1.891   0.595   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       0.777   0.595   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       0.777  -0.945   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       2.110  -1.715   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       3.444  -4.025   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       2.110  -3.255   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       0.777  -4.025   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      -0.557   1.365   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      -0.557   2.905   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0       2.110  -6.335   0.000  0.00  0.00           O+0
HETATM   21  C   UNK     0       3.444  -5.565   0.000  0.00  0.00           C+0
HETATM   22  O   UNK     0       4.778  -6.335   0.000  0.00  0.00           O+0
CONECT    1    5    2                                                       
CONECT    2    1    3                                                       
CONECT    3    2    7                                                       
CONECT    4    5                                                            
CONECT    5    1    9    4    6                                             
CONECT    6    5                                                            
CONECT    7    3    9    8                                                  
CONECT    8    7                                                            
CONECT    9    5    7   10                                                  
CONECT   10    9   11                                                       
CONECT   11   10   18                                                       
CONECT   12   18   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   16                                                       
CONECT   15   16   21                                                       
CONECT   16   14   15   17                                                  
CONECT   17   16                                                            
CONECT   18   11   12   19                                                  
CONECT   19   18                                                            
CONECT   20   21                                                            
CONECT   21   15   20   22                                                  
CONECT   22   21                                                            
MASTER        0    0    0    0    0    0    0    0   22    0   44    0
END

COMPND    HMDB0002369
HETATM    1  C1  UNL     1      -2.959   3.214   1.809  1.00  0.00           C  
HETATM    2  C2  UNL     1      -3.141   2.265   0.661  1.00  0.00           C  
HETATM    3  C3  UNL     1      -2.134   1.435   0.408  1.00  0.00           C  
HETATM    4  C4  UNL     1      -0.930   1.514   1.266  1.00  0.00           C  
HETATM    5  C5  UNL     1       0.159   0.816   1.192  1.00  0.00           C  
HETATM    6  C6  UNL     1       1.313   0.934   2.064  1.00  0.00           C  
HETATM    7  C7  UNL     1       1.327   1.938   3.203  1.00  0.00           C  
HETATM    8  C8  UNL     1       2.366   0.176   1.893  1.00  0.00           C  
HETATM    9  C9  UNL     1       2.481  -0.817   0.857  1.00  0.00           C  
HETATM   10  C10 UNL     1       3.581  -1.557   0.731  1.00  0.00           C  
HETATM   11  C11 UNL     1       3.710  -2.553  -0.299  1.00  0.00           C  
HETATM   12  C12 UNL     1       2.669  -2.848  -1.300  1.00  0.00           C  
HETATM   13  C13 UNL     1       4.848  -3.267  -0.370  1.00  0.00           C  
HETATM   14  C14 UNL     1       5.115  -4.299  -1.351  1.00  0.00           C  
HETATM   15  O1  UNL     1       4.307  -4.647  -2.248  1.00  0.00           O  
HETATM   16  O2  UNL     1       6.330  -4.991  -1.355  1.00  0.00           O  
HETATM   17  C15 UNL     1      -2.206   0.463  -0.681  1.00  0.00           C  
HETATM   18  C16 UNL     1      -1.270   0.878  -1.807  1.00  0.00           C  
HETATM   19  C17 UNL     1      -1.836  -0.960  -0.256  1.00  0.00           C  
HETATM   20  C18 UNL     1      -3.616   0.342  -1.221  1.00  0.00           C  
HETATM   21  C19 UNL     1      -4.309   1.640  -1.429  1.00  0.00           C  
HETATM   22  C20 UNL     1      -4.391   2.346  -0.078  1.00  0.00           C  
HETATM   23  H1  UNL     1      -2.121   3.896   1.664  1.00  0.00           H  
HETATM   24  H2  UNL     1      -3.883   3.785   1.928  1.00  0.00           H  
HETATM   25  H3  UNL     1      -2.859   2.582   2.730  1.00  0.00           H  
HETATM   26  H4  UNL     1      -0.969   2.256   2.058  1.00  0.00           H  
HETATM   27  H5  UNL     1       0.222   0.091   0.408  1.00  0.00           H  
HETATM   28  H6  UNL     1       2.231   2.565   2.972  1.00  0.00           H  
HETATM   29  H7  UNL     1       1.619   1.405   4.152  1.00  0.00           H  
HETATM   30  H8  UNL     1       0.426   2.511   3.291  1.00  0.00           H  
HETATM   31  H9  UNL     1       3.224   0.310   2.596  1.00  0.00           H  
HETATM   32  H10 UNL     1       1.672  -0.973   0.173  1.00  0.00           H  
HETATM   33  H11 UNL     1       4.368  -1.363   1.446  1.00  0.00           H  
HETATM   34  H12 UNL     1       3.155  -2.691  -2.312  1.00  0.00           H  
HETATM   35  H13 UNL     1       1.826  -2.164  -1.301  1.00  0.00           H  
HETATM   36  H14 UNL     1       2.360  -3.919  -1.294  1.00  0.00           H  
HETATM   37  H15 UNL     1       5.605  -3.014   0.393  1.00  0.00           H  
HETATM   38  H16 UNL     1       7.179  -4.602  -1.748  1.00  0.00           H  
HETATM   39  H17 UNL     1      -1.847   1.633  -2.409  1.00  0.00           H  
HETATM   40  H18 UNL     1      -0.320   1.297  -1.447  1.00  0.00           H  
HETATM   41  H19 UNL     1      -1.044   0.021  -2.475  1.00  0.00           H  
HETATM   42  H20 UNL     1      -2.745  -1.601  -0.500  1.00  0.00           H  
HETATM   43  H21 UNL     1      -1.716  -1.077   0.823  1.00  0.00           H  
HETATM   44  H22 UNL     1      -1.017  -1.307  -0.890  1.00  0.00           H  
HETATM   45  H23 UNL     1      -4.178  -0.225  -0.437  1.00  0.00           H  
HETATM   46  H24 UNL     1      -3.555  -0.287  -2.138  1.00  0.00           H  
HETATM   47  H25 UNL     1      -3.766   2.246  -2.172  1.00  0.00           H  
HETATM   48  H26 UNL     1      -5.336   1.464  -1.815  1.00  0.00           H  
HETATM   49  H27 UNL     1      -5.169   1.765   0.492  1.00  0.00           H  
HETATM   50  H28 UNL     1      -4.778   3.371  -0.263  1.00  0.00           H  
CONECT    1    2   23   24   25
CONECT    2    3    3   22
CONECT    3    4   17
CONECT    4    5    5   26
CONECT    5    6   27
CONECT    6    7    8    8
CONECT    7   28   29   30
CONECT    8    9   31
CONECT    9   10   10   32
CONECT   10   11   33
CONECT   11   12   13   13
CONECT   12   34   35   36
CONECT   13   14   37
CONECT   14   15   15   16
CONECT   16   38
CONECT   17   18   19   20
CONECT   18   39   40   41
CONECT   19   42   43   44
CONECT   20   21   45   46
CONECT   21   22   47   48
CONECT   22   49   50
END

HMDB0002369
     RDKit          3D
9-cis-Retinoic acid
 50 50  0  0  0  0  0  0  0  0999 V2000
   -2.9590    3.2142    1.8094 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1409    2.2653    0.6613 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1341    1.4348    0.4076 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9297    1.5138    1.2663 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1595    0.8158    1.1915 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3135    0.9340    2.0643 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3274    1.9377    3.2033 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3660    0.1763    1.8927 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4811   -0.8172    0.8568 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5806   -1.5569    0.7313 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7097   -2.5534   -0.2991 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6691   -2.8481   -1.2997 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8477   -3.2670   -0.3703 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1150   -4.2994   -1.3508 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3071   -4.6468   -2.2477 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3300   -4.9906   -1.3548 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2057    0.4627   -0.6811 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2702    0.8780   -1.8069 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8355   -0.9597   -0.2560 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6160    0.3419   -1.2211 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3085    1.6397   -1.4293 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3915    2.3457   -0.0779 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1213    3.8963    1.6635 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8832    3.7852    1.9280 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8587    2.5823    2.7295 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9689    2.2565    2.0583 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2220    0.0914    0.4079 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2312    2.5653    2.9718 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6188    1.4052    4.1520 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4256    2.5113    3.2915 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2243    0.3097    2.5957 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6723   -0.9726    0.1735 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3680   -1.3634    1.4458 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1551   -2.6910   -2.3116 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8256   -2.1637   -1.3012 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3602   -3.9194   -1.2937 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6052   -3.0140    0.3927 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.1785   -4.6017   -1.7484 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8467    1.6331   -2.4092 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3197    1.2974   -1.4470 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0441    0.0209   -2.4745 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7452   -1.6013   -0.4998 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7163   -1.0768    0.8228 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0165   -1.3067   -0.8900 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1776   -0.2249   -0.4372 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5553   -0.2867   -2.1381 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7662    2.2460   -2.1722 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3358    1.4642   -1.8146 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1688    1.7650    0.4917 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7780    3.3715   -0.2626 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  6  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 11 13  2  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
  3 17  1  0
 17 18  1  0
 17 19  1  0
 17 20  1  0
 20 21  1  0
 21 22  1  0
 22  2  1  0
  1 23  1  0
  1 24  1  0
  1 25  1  0
  4 26  1  0
  5 27  1  0
  7 28  1  0
  7 29  1  0
  7 30  1  0
  8 31  1  0
  9 32  1  0
 10 33  1  0
 12 34  1  0
 12 35  1  0
 12 36  1  0
 13 37  1  0
 16 38  1  0
 18 39  1  0
 18 40  1  0
 18 41  1  0
 19 42  1  0
 19 43  1  0
 19 44  1  0
 20 45  1  0
 20 46  1  0
 21 47  1  0
 21 48  1  0
 22 49  1  0
 22 50  1  0
M  END

View in JSmol View Stereo Labels

Synonyms

Value	Source
(2E,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid	ChEBI
(7E,9Z,11E,13E)-Retinoic acid	ChEBI
9(Z)-Retinoic acid	ChEBI
9-cis-Tretinoin	ChEBI
Alitretinoin	ChEBI
Alitretinoina	ChEBI
Alitretinoine	ChEBI
Alitretinoinum	ChEBI
Panretin	ChEBI
Panretyn	ChEBI
(2E,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate	Generator
(7E,9Z,11E,13E)-Retinoate	Generator
9(Z)-Retinoate	Generator
9-cis-Retinoate	Generator
9 cis Retinoic acid	MeSH
9CRA compound	MeSH
Toctino	MeSH
15-apo-beta-Caroten-15-Oate	HMDB
15-apo-beta-Caroten-15-Oic acid	HMDB
9-Retinoate	HMDB
9-Retinoic acid	HMDB
Aberel	HMDB
Aberela	HMDB
Airol	HMDB
Aknoten	HMDB
all-trans- Vitamin a1 acid	HMDB
all-trans-b-Retinoate	HMDB
all-trans-b-Retinoic acid	HMDB
all-trans-beta-Retinoate	HMDB
all-trans-beta-Retinoic acid	HMDB
all-trans-Vitamin a acid	HMDB
alpha-Vitaminsyre	HMDB
Atragen	HMDB
Avita	HMDB
Avitoin	HMDB
b-Retinoate	HMDB
b-Retinoic acid	HMDB
beta-Retinoate	HMDB
beta-Retinoic acid	HMDB
Dermairol	HMDB
Effederm	HMDB
Epi-aberel	HMDB
Eudyna	HMDB
Isotretinoin retinoate	HMDB
Isotretinoin retinoic acid	HMDB
Panretin gel	HMDB
Panrexin	HMDB
Renova	HMDB
Retacnyl	HMDB
Retin a	HMDB
Retin-a	HMDB
Retin-a micro	HMDB
Retinoate	HMDB
Retinoic acid	HMDB
Retinova	HMDB
trans-Retinoate	HMDB
trans-Retinoic acid	HMDB
trans-Vitamin a acid	HMDB
Tretinoin	HMDB
Tretinoin/all-trans retinoate	HMDB
Tretinoin/all-trans retinoic acid	HMDB
Tretinon	HMDB
Vesanoid	HMDB
Vesnaroid	HMDB

Chemical Formula

C₂₀H₂₈O₂

Average Molecular Weight

300.4351

Monoisotopic Molecular Weight

300.20893014

IUPAC Name

(2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid

Traditional Name

alitretinoin

CAS Registry Number

5300-03-8

SMILES

C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O

InChI Identifier

InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+

InChI Key

SHGAZHPCJJPHSC-ZVCIMWCZSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as retinoids. These are oxygenated derivatives of 3,7-dimethyl-1-(2,6,6-trimethylcyclohex-1-enyl)nona-1,3,5,7-tetraene and derivatives thereof.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Retinoids

Direct Parent

Retinoids

Alternative Parents

Substituents

Retinoic acid
Diterpenoid
Retinoid skeleton
Medium-chain fatty acid
Branched fatty acid
Methyl-branched fatty acid
Fatty acyl
Unsaturated fatty acid
Fatty acid
Monocarboxylic acid or derivatives
Carboxylic acid
Carboxylic acid derivative
Hydrocarbon derivative
Organooxygen compound
Organic oxide
Organic oxygen compound
Carbonyl group
Aliphatic homomonocyclic compound

Molecular Framework

Aliphatic homomonocyclic compounds

External Descriptors

retinoic acid (CHEBI:50648 )
Retinoids (C15493 )
Retinoids (LMPR01090022 )

Ontology

Physiological effect

Not Available

Disposition

Biological location

Non-excretory biofluid

Biofluid or Excreta

Blood (PMID: 8699330)

Cellular substructure

Extracellular (HMDB: HMDB0002369)
Membrane (HMDB: HMDB0002369)

Source

Exogenous

Exogenous (HMDB: HMDB0002369)

Endogenous

Endogenous (HMDB: HMDB0002369)

Process

Naturally occurring process

Biological process

Biochemical pathway

Metabolic pathway

Retinol Metabolism (HMDB: HMDB0002369)

Disease pathway

Vitamin A Deficiency (PathBank: SMP0120500)

Role

Physical Properties

State

Solid

Experimental Molecular Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct Type	Data Source	CCS Value (Å²)	Reference
[M-H]-	MetCCS_train_neg	200.006	30932474

Predicted Molecular Properties

Property	Value	Source
Water Solubility	0.0048 g/L	ALOGPS
logP	5.66	ALOGPS
logP	5.01	ChemAxon
logS	-4.8	ALOGPS
pKa (Strongest Acidic)	5	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	37.3 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	97.79 m³·mol⁻¹	ChemAxon
Polarizability	35.89 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted Chromatographic Properties

Predicted Collision Cross Sections

Predictor	Adduct Type	CCS Value (Å²)	Reference
DarkChem	[M+H]+	178.17	31661259
DarkChem	[M-H]-	177.237	31661259
DeepCCS	[M+H]+	199.605	30932474
DeepCCS	[M-H]-	197.247	30932474
DeepCCS	[M-2H]-	230.785	30932474
DeepCCS	[M+Na]+	206.012	30932474
AllCCS	[M+H]+	178.0	32859911
AllCCS	[M+H-H2O]+	174.9	32859911
AllCCS	[M+NH4]+	180.9	32859911
AllCCS	[M+Na]+	181.8	32859911
AllCCS	[M-H]-	181.1	32859911
AllCCS	[M+Na-2H]-	181.7	32859911
AllCCS	[M+HCOO]-	182.5	32859911

Predicted Kovats Retention Indices

Underivatized

Metabolite	SMILES	Kovats RI Value	Column Type	Reference
9-cis-Retinoic acid	C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O	3735.6	Standard polar	33892256
9-cis-Retinoic acid	C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O	2481.2	Standard non polar	33892256
9-cis-Retinoic acid	C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O	2553.2	Semi standard non polar	33892256

Derivatized

Derivative Name / Structure	SMILES	Kovats RI Value	Column Type	Reference
9-cis-Retinoic acid,1TMS,isomer #1	CC1=C(/C=C/C(C)=C\C=C\C(C)=C\C(=O)O[Si](C)(C)C)C(C)(C)CCC1	2701.4	Semi standard non polar	33892256
9-cis-Retinoic acid,1TBDMS,isomer #1	CC1=C(/C=C/C(C)=C\C=C\C(C)=C\C(=O)O[Si](C)(C)C(C)(C)C)C(C)(C)CCC1	2906.6	Semi standard non polar	33892256

Spectra

GC-MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted GC-MS	Predicted GC-MS Spectrum - 9-cis-Retinoic acid GC-MS (Non-derivatized) - 70eV, Positive	splash10-000i-2190000000-86aaab132a5b092ebf10	2017-09-01	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - 9-cis-Retinoic acid GC-MS (1 TMS) - 70eV, Positive	splash10-0a4i-5139000000-29caedb85908ca2b99f4	2017-10-06	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - 9-cis-Retinoic acid GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	Wishart Lab	View Spectrum

MS/MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 9-cis-Retinoic acid 10V, Positive-QTOF	splash10-0uei-0494000000-28e6366fdd47e8ba2117	2016-06-03	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 9-cis-Retinoic acid 20V, Positive-QTOF	splash10-052r-2980000000-3e7fc78de83c23830416	2016-06-03	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 9-cis-Retinoic acid 40V, Positive-QTOF	splash10-052r-5900000000-ef4d86f8bcf86959f794	2016-06-03	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 9-cis-Retinoic acid 10V, Negative-QTOF	splash10-052b-0090000000-e07ffb4c1e5c63ab1b59	2016-08-03	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 9-cis-Retinoic acid 20V, Negative-QTOF	splash10-052b-0090000000-a0a8411213bbd2543243	2016-08-03	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 9-cis-Retinoic acid 40V, Negative-QTOF	splash10-000i-3690000000-97e6a74798dd69c30ad1	2016-08-03	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 9-cis-Retinoic acid 10V, Negative-QTOF	splash10-052b-0090000000-5f942e3b870e7bd0121b	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 9-cis-Retinoic acid 20V, Negative-QTOF	splash10-0a4i-0190000000-22b445382d3977280045	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 9-cis-Retinoic acid 40V, Negative-QTOF	splash10-016r-4900000000-0005b37f6d54a42a84f6	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 9-cis-Retinoic acid 10V, Positive-QTOF	splash10-0zir-0973000000-3040e9e4a1a5448efbcb	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 9-cis-Retinoic acid 20V, Positive-QTOF	splash10-060c-1950000000-f3b9c9b378f60b8c49a9	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 9-cis-Retinoic acid 40V, Positive-QTOF	splash10-0ar3-5910000000-de22eb65f274483f3f98	2021-09-22	Wishart Lab	View Spectrum

Biological Properties

Cellular Locations

Extracellular
Membrane

Biospecimen Locations

Blood

Tissue Locations

Not Available

Pathways

Name	SMPDB/PathBank	KEGG
Retinol Metabolism
Vitamin A Deficiency		Not Available

Normal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Blood	Detected and Quantified	0.0042 +/-0.001 uM	Adult (>18 years old)	Male	Normal	8699330	details
Blood	Detected and Quantified	0.0056 +/- 0.002 uM	Adult (>18 years old)	Female	Normal	8699330	details

Abnormal Concentrations

Not Available

Associated Disorders and Diseases

Disease References

None

Associated OMIM IDs

None

External Links

DrugBank ID

DB00523

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB001084

KNApSAcK ID

Not Available

Chemspider ID

395778

KEGG Compound ID

C15493

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Alitretinoin

METLIN ID

Not Available

PubChem Compound

449171

PDB ID

Not Available

ChEBI ID

50648

Food Biomarker Ontology

Not Available

VMH ID

Not Available

MarkerDB ID

Not Available

Good Scents ID

Not Available

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Not Available

General References

Mertz JR, Shang E, Piantedosi R, Wei S, Wolgemuth DJ, Blaner WS: Identification and characterization of a stereospecific human enzyme that catalyzes 9-cis-retinol oxidation. A possible role in 9-cis-retinoic acid formation. J Biol Chem. 1997 May 2;272(18):11744-9. [PubMed:9115228 ]

Enzymes

Enzyme Details

1. Retinal dehydrogenase 1

General function:: Involved in oxidoreductase activity
Specific function:: Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity).
Gene Name:: ALDH1A1
Uniprot ID:: P00352
Molecular weight:: 54861.44

Reactions

9-cis-Retinal + NAD + Water → 9-cis-Retinoic acid + NADH + Hydrogen Ion	details

Enzyme Details

2. Retinal dehydrogenase 2

General function:: Involved in oxidoreductase activity
Specific function:: Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity).
Gene Name:: ALDH1A2
Uniprot ID:: O94788
Molecular weight:: 54672.24

Reactions

9-cis-Retinal + NAD + Water → 9-cis-Retinoic acid + NADH + Hydrogen Ion	details

Enzyme Details

3. Retinoic acid receptor RXR-beta

General function:: Involved in sequence-specific DNA binding transcription factor activity
Specific function:: Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA)
Gene Name:: RXRB
Uniprot ID:: P28702
Molecular weight:: 56921.4

Enzyme Details

4. Retinoic acid receptor RXR-gamma

General function:: Involved in sequence-specific DNA binding transcription factor activity
Specific function:: Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA)
Gene Name:: RXRG
Uniprot ID:: P48443
Molecular weight:: 50870.7

Enzyme Details

5. Retinoic acid receptor RXR-alpha

General function:: Involved in sequence-specific DNA binding transcription factor activity
Specific function:: Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA). ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer
Gene Name:: RXRA
Uniprot ID:: P19793
Molecular weight:: 50810.8

Showing metabocard for 9-cis-Retinoic acid (HMDB0002369)

MOL for HMDB0002369 (9-cis-Retinoic acid)

3D MOL for HMDB0002369 (9-cis-Retinoic acid)

3D SDF for HMDB0002369 (9-cis-Retinoic acid)

3D-SDF for HMDB0002369 (9-cis-Retinoic acid)

PDB for HMDB0002369 (9-cis-Retinoic acid)

3D PDB for HMDB0002369 (9-cis-Retinoic acid)

SMILES for HMDB0002369 (9-cis-Retinoic acid)

INCHI for HMDB0002369 (9-cis-Retinoic acid)

Structure for HMDB0002369 (9-cis-Retinoic acid)

3D Structure for HMDB0002369 (9-cis-Retinoic acid)

Experimental Collision Cross Sections

Predicted Collision Cross Sections

Predicted Kovats Retention Indices

Underivatized

Derivatized

GC-MS Spectra

MS/MS Spectra

Enzymes

Reactions

Reactions