| Entry |
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| Symbol |
PLK4, MCCRP2, SAK, STK18
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| Name |
(RefSeq) polo like kinase 4
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| KO |
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| Organism |
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| Pathway |
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| Disease |
| H01880 | Autosomal recessive microcephaly and chorioretinopathy |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04068 FoxO signaling pathway
10733 (PLK4)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
10733 (PLK4)
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:hsa03036]
10733 (PLK4)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.21 polo kinase
10733 (PLK4)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: Other
PLK family [OT]
10733 (PLK4)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
Centrosome formation proteins
Kinases and associated factors
10733 (PLK4)
Centrosome duplication proteins
Regulators of centriole replication
10733 (PLK4)
Sister chromatid separation proteins
Polo kinases
10733 (PLK4)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
4:127880893..127899224
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| AA seq |
970 aa
MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNE
VKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQI
ITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISP
EIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKD
LIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDSGHATISTAITASSST
SISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFYTQWGNQETSNSGRGRV
IQDAEERPHSRYLRRAYSSDRSGTSNSQSQAKTYTMERCHSAEMLSVSKRSGGGENEERY
SPTDNNANIFNFFKEKTSSSSGSFERPDNNQALSNHLCPGKTPFPFADPTPQTETVQQWF
GNLQINAHLRKTTEYDSISPNRDFQGHPDLQKDTSKNAWTDTKVKKNSDASDNAHSVKQQ
NTMKYMTALHSKPEIIQQECVFGSDPLSEQSKTRGMEPPWGYQNRTLRSITSPLVAHRLK
PIRQKTKKAVVSILDSEEVCVELVKEYASQEYVKEVLQISSDGNTITIYYPNGGRGFPLA
DRPPSPTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCILMENSPG
ADFEVWFYDGVKIHKTEDFIQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGHRICL
ALESIISEEERKTRSAPFFPIIIGRKPGSTSSPKALSPPPSVDSNYPTRERASFNRMVMH
SAASPTQAPILNPSMVTNEGLGLTTTASGTDISSNSLKDCLPKSAQLLKSVFVKNVGWAT
QLTSGAVWVQFNDGSQLVVQAGVSSISYTSPNGQTTRYGENEKLPDYIKQKLQCLSSILL
MFSNPTPNFH |
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| NT seq |
2913 nt +upstreamnt +downstreamnt
atggcgacctgcatcggggagaagatcgaggattttaaagttggaaatctgcttggtaaa
ggatcatttgctggtgtctacagagctgagtccattcacactggtttggaagttgcaatc
aaaatgatagataagaaagccatgtacaaagcaggaatggtacagagagtccaaaatgag
gtgaaaatacattgccaattgaaacatccttctatcttggagctttataactattttgaa
gatagcaattatgtgtatctggtattagaaatgtgccataatggagaaatgaacaggtat
ctaaagaatagagtgaaacccttctcagaaaatgaagctcgacacttcatgcaccagatc
atcacagggatgttgtatcttcattctcatggtatactacaccgggacctcacactttct
aacctcctactgactcgtaatatgaacatcaagattgctgattttgggctggcaactcaa
ctgaaaatgccacatgaaaagcactatacattatgtggaactcctaactacatttcacca
gaaattgccactcgaagtgcacatggccttgaatctgatgtttggtccctgggctgtatg
ttttatacattacttatcgggagaccacccttcgacactgacacagtcaagaacacatta
aataaagtagtattggcagattatgaaatgccatcttttttgtcaatagaggccaaggac
cttattcaccagttacttcgtagaaatccagcagatcgtttaagtctgtcttcagtattg
gaccatccttttatgtcccgaaattcttcaacaaaaagtaaagatttaggaactgtggaa
gactcaattgatagtgggcatgccacaatttctactgcaattacagcttcttccagtacc
agtataagtggtagtttatttgacaaaagaagacttttgattggtcagccactcccaaat
aaaatgactgtatttccaaagaataaaagttcaactgatttttcttcttcaggagatgga
aacagtttttatactcagtggggaaatcaagaaaccagtaatagtggaaggggaagagta
attcaagatgcagaagaaaggccacattctcgataccttcgtagagcttattcctctgat
agatctggcacttctaatagtcagtctcaagcaaaaacatatacaatggaacgatgtcac
tcagcagaaatgctttcagtgtccaaaagatcaggaggaggtgaaaatgaagagaggtac
tcacccacagacaacaatgccaacatttttaacttctttaaagaaaagacatccagtagt
tctggatcttttgaaagacctgataacaatcaagcactctccaatcatctttgtccagga
aaaactccttttccatttgcagacccgacacctcagactgaaaccgtacaacagtggttt
gggaatctgcaaataaatgctcatttaagaaaaactactgaatatgacagcatcagccca
aaccgggacttccagggccatccagatttgcagaaggacacatcaaaaaatgcctggact
gatacaaaagtcaaaaagaactctgatgcttctgataatgcacattctgtaaaacagcaa
aataccatgaaatatatgactgcacttcacagtaaacctgagataatccaacaagaatgt
gtttttggctcagatcctctttctgaacagagcaagactaggggtatggagccaccatgg
ggttatcagaatcgtacattaagaagcattacatctccgttggttgctcacaggttaaaa
ccaatcagacagaaaaccaaaaaggctgtggtgagcatacttgattcagaggaggtgtgt
gtggagcttgtaaaggagtatgcatctcaagaatatgtgaaagaagttcttcagatatct
agtgatggaaatacgatcactatttattatccaaatggtggtagaggttttcctcttgct
gatagaccaccctcacctactgacaacatcagtaggtacagctttgacaatttaccagaa
aaatactggcgaaaatatcaatatgcttccaggtttgtacagcttgtaagatctaaatct
cccaaaatcacttattttacaagatatgctaaatgcattttgatggagaattctcctggt
gctgattttgaggtttggttttatgatggggtaaaaatacacaaaacagaagatttcatt
caggtgattgaaaagacagggaagtcttacactttaaaaagtgaaagtgaagttaatagc
ttgaaagaggagataaaaatgtatatggaccatgctaatgagggtcatcgtatttgttta
gcactggaatccataatttcagaagaggaaaggaaaactaggagtgctccctttttccca
ataatcataggaagaaaacctggtagtactagttcacctaaggccttatcacctcctcct
tctgtggattcaaattacccaacgagagagagagcatctttcaacagaatggtcatgcat
agtgctgcttctccaacacaggcaccaatccttaatccctctatggttacaaatgaagga
cttggtcttacaactacagcttctggaacagacatctcttctaatagtctaaaagattgt
cttcctaaatcagcacaacttttgaaatctgtttttgtgaaaaatgttggttgggctaca
cagttaactagtggagctgtgtgggttcagtttaatgatgggtcccagttggttgtgcag
gcaggagtgtcttctatcagttatacctcaccaaatggtcaaacaactaggtatggagaa
aatgaaaaattaccagactacatcaaacagaaattacagtgtctgtcttccatccttttg
atgttttctaatccgactcctaattttcattga |
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