| Entry |
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| Symbol |
MAN1B1, ERMAN1, ERManI, MANA-ER, MRT15
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| Name |
(RefSeq) mannosidase alpha class 1B member 1
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| KO |
| K23741 | endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase [EC:3.2.1.209] |
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| Organism |
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| Pathway |
| hsa00513 | Various types of N-glycan biosynthesis |
| hsa04141 | Protein processing in endoplasmic reticulum |
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| Module |
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| Network |
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| Element |
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| Disease |
| H00768 | Autosomal recessive intellectual developmental disorder |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09107 Glycan biosynthesis and metabolism
00510 N-Glycan biosynthesis
11253 (MAN1B1)
00513 Various types of N-glycan biosynthesis
11253 (MAN1B1)
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
11253 (MAN1B1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:hsa04131]
11253 (MAN1B1)
Enzymes [BR:hsa01000]
3. Hydrolases
3.2 Glycosylases
3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
3.2.1.209 endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
11253 (MAN1B1)
Membrane trafficking [BR:hsa04131]
Endoplasmic reticulum (ER) - Golgi transport
Forward pathways
ER-Golgi intermediate compartment (ERGIC) proteins
11253 (MAN1B1)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
9:137086985..137109183
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| AA seq |
699 aa
MAACEGRRSGALGSSQSDFLTPPVGGAPWAVATTVVMYPPPPPPPHRDFISVTLSFGENY
DNSKSWRRRSCWRKWKQLSRLQRNMILFLLAFLLFCGLLFYINLADHWKALAFRLEEEQK
MRPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDG
TQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQ
GTPVHLNYRQKGVIDVFLHAWKGYRKFAWGHDELKPVSRSFSEWFGLGLTLIDALDTMWI
LGLRKEFEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGN
RLMPAFRTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQLEFRELSRLTGDKKFQEA
VEKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQE
TQLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHGRFSAKMDHLVCFLPGTLALGVYHG
LPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPET
VESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKMESFF
LGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPIWTPA |
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| NT seq |
2100 nt +upstreamnt +downstreamnt
atggctgcctgcgagggcaggagaagcggagctctcggttcctctcagtcggacttcctg
acgccgccagtgggcggggccccttgggccgtcgccaccactgtagtcatgtacccaccg
ccgccgccgccgcctcatcgggacttcatctcggtgacgctgagctttggcgagaactat
gacaacagcaagagttggcggcggcgctcgtgctggaggaaatggaagcaactgtcgaga
ttgcagcggaatatgattctcttcctccttgcctttctgcttttctgtggactcctcttc
tacatcaacttggctgaccattggaaagctctggctttcaggctagaggaagagcagaag
atgaggccagaaattgctgggttaaaaccagcaaatccacccgtcttaccagctcctcag
aaggcggacaccgaccctgagaacttacctgagatttcgtcacagaagacacaaagacac
atccagcggggaccacctcacctgcagattagacccccaagccaagacctgaaggatggg
acccaggaggaggccacaaaaaggcaagaagcccctgtggatccccgcccggaaggagat
ccgcagaggacagtcatcagctggaggggagcggtgatcgagcctgagcagggcaccgag
ctcccttcaagaagagcagaagtgcccaccaagcctcccctgccaccggccaggacacag
ggcacaccagtgcatctgaactatcgccagaagggcgtgattgacgtcttcctgcatgca
tggaaaggataccgcaagtttgcatggggccatgacgagctgaagcctgtgtccaggtcc
ttcagtgagtggtttggcctcggtctcacactgatcgacgcgctggacaccatgtggatc
ttgggtctgaggaaagaatttgaggaagccaggaagtgggtgtcgaagaagttacacttt
gaaaaggacgtggacgtcaacctgtttgagagcacgatccgcatcctgggggggctcctg
agtgcctaccacctgtctggggacagcctcttcctgaggaaagctgaggattttggaaat
cggctaatgcctgccttcagaacaccatccaagattccttactcggatgtgaacatcggt
actggagttgcccacccgccacggtggacctccgacagcactgtggccgaggtgaccagc
attcagctggagttccgggagctctcccgtctcacaggggataagaagtttcaggaggca
gtggagaaggtgacacagcacatccacggcctgtctgggaagaaggatgggctggtgccc
atgttcatcaatacccacagtggcctcttcacccacctgggcgtattcacgctgggcgcc
agggccgacagctactatgagtacctgctgaagcagtggatccagggcgggaagcaggag
acacagctgctggaagactacgtggaagccatcgagggtgtcagaacgcacctgctgcgg
cactccgagcccagtaagctcacctttgtgggggagcttgcccacggccgcttcagtgcc
aagatggaccacctggtgtgcttcctgccagggacgctggctctgggcgtctaccacggc
ctgcccgccagccacatggagctggcccaggagctcatggagacttgttaccagatgaac
cggcagatggagacggggctgagtcccgagatcgtgcacttcaacctttacccccagccg
ggccgtcgggacgtggaggtcaagccagcagacaggcacaacctgctgcggccagagacc
gtggagagcctgttctacctgtaccgcgtcacaggggaccgcaaataccaggactggggc
tgggagattctgcagagcttcagccgattcacacgggtcccctcgggtggctattcttcc
atcaacaatgtccaggatcctcagaagcccgagcctagggacaagatggagagcttcttc
ctgggggagacgctcaagtatctgttcttgctcttctccgatgacccaaacctgctcagc
ctggatgcctacgtgttcaacaccgaagcccaccctctgcctatctggacccctgcctag |
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