KEGG   Homo sapiens (human): 1723
Entry
1723              CDS       T01001                                 
Symbol
DHODH, DHOdehase, POADS, URA1
Name
(RefSeq) dihydroorotate dehydrogenase (quinone)
  KO
K00254  dihydroorotate dehydrogenase [EC:1.3.5.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00240  Pyrimidine metabolism
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
Module
hsa_M00051  De novo pyrimidine biosynthesis, glutamine (+ PRPP) => UMP
Disease
H01376  Acrofacial dysostosis
Drug target
Brequinar sodium: D03154
Emvododstat: D11890
Leflunomide: D00749<JP/US>
Teriflunomide: D10172<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    1723 (DHODH)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.5  With a quinone or related compound as acceptor
    1.3.5.2  dihydroorotate dehydrogenase (quinone)
     1723 (DHODH)
SSDB
Motif
Pfam: DHO_dh FMN_dh Trp_syntA NMO
Other DBs
NCBI-GeneID: 1723
NCBI-ProteinID: NP_001352
OMIM: 126064
HGNC: 2867
Ensembl: ENSG00000102967
UniProt: Q02127
Structure
LinkDB
Position
16:72008744..72027659
AA seq 395 aa
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
NT seq 1188 nt   +upstreamnt  +downstreamnt
atggcgtggagacacctgaaaaagcgggcccaggatgctgtgatcatcctggggggagga
ggacttctcttcgcctcctacctgatggccacgggagatgagcgtttctatgctgaacac
ctgatgccgactctgcaggggctgctggacccggagtcagcccacagactggctgttcgc
ttcacctccctggggctccttccacgggccagatttcaagactctgacatgctggaagtg
agagttctgggccataaattccgaaatccagtaggaattgctgcaggatttgacaagcat
ggggaagccgtggacggactttataagatgggctttggttttgttgagataggaagtgtg
actccaaaacctcaggaaggaaaccctagacccagagtcttccgcctccctgaggaccaa
gctgtcattaacaggtatggatttaacagtcacgggctttcagtggtggaacacaggtta
cgggccagacagcagaagcaggccaagctcacagaagatggactgcctctgggggtcaac
ttggggaagaacaagacctcagtggacgccgcggaggactacgcagaaggggtgcgcgta
ctgggccccctggccgactacctggtggtgaatgtgtccagccccaacactgccgggctg
cggagccttcagggaaaggccgagctgcgccgcctgctgaccaaggtgctgcaggagagg
gatggcttgcggagagtgcacaggccggcagtcctggtgaagatcgctcctgacctcacc
agccaggataaggaggacattgccagtgtggtcaaagagttgggcatcgatgggctgatt
gttacgaacaccaccgtgagtcgccctgcgggcctccagggtgccctgcgctctgaaaca
ggagggctgagtgggaagcccctccgggatttatcaactcaaaccattcgggagatgtat
gcactcacccaaggccgagttcccataattggggttggtggtgtgagcagcgggcaggac
gcgctggagaagatccgggcaggggcctccctggtgcagctgtacacggccctcaccttc
tgggggccacccgttgtgggcaaagtcaagcgggaactggaggcccttctgaaagagcag
ggctttggcggagtcacagatgccattggagcagatcatcggaggtga

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