KEGG   Homo sapiens (human): 1848
Entry
1848              CDS       T01001                                 
Symbol
DUSP6, HH19, MKP3, PYST1
Name
(RefSeq) dual specificity phosphatase 6
  KO
K21946  dual specificity phosphatase 6 [EC:3.1.3.16 3.1.3.48]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa05202  Transcriptional misregulation in cancer
hsa05221  Acute myeloid leukemia
Network
nt06240  Transcription (cancer)
nt06275  Acute myeloid leukemia
nt06526  MAPK signaling
  Element
N00114  PLZF-RARA fusion to transcriptional repression
N01593  Regulation of GF-RTK-RAS-ERK signaling, PTP
Disease
H00255  Hypogonadotropic hypogonadism
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    1848 (DUSP6)
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    1848 (DUSP6)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    1848 (DUSP6)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     1848 (DUSP6)
    3.1.3.48  protein-tyrosine-phosphatase
     1848 (DUSP6)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   MAPK phosphatases
    1848 (DUSP6)
SSDB
Motif
Pfam: DSPc Rhodanese Tc-R-P PTP-SAK Y_phosphatase Init_tRNA_PT PTPlike_phytase
Other DBs
NCBI-GeneID: 1848
NCBI-ProteinID: NP_001937
OMIM: 602748
HGNC: 3072
Ensembl: ENSG00000139318
UniProt: Q16828
Structure
LinkDB
Position
12:complement(89347235..89352501)
AA seq 381 aa
MIDTLRPVPFASEMAISKTVAWLNEQLELGNERLLLMDCRPQELYESSHIESAINVAIPG
IMLRRLQKGNLPVRALFTRGEDRDRFTRRCGTDTVVLYDESSSDWNENTGGESVLGLLLK
KLKDEGCRAFYLEGGFSKFQAEFSLHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDI
ESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVT
PNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRS
VTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQ
QLYFTTPSNQNVYQVDSLQST
NT seq 1146 nt   +upstreamnt  +downstreamnt
atgatagatacgctcagacccgtgcccttcgcgtcggaaatggcgatcagcaagacggtg
gcgtggctcaacgagcagctggagctgggcaacgagcggctgctgctgatggactgccgg
ccgcaggagctatacgagtcgtcgcacatcgagtcggccatcaacgtggccatcccgggc
atcatgctgcggcgcctgcagaagggtaacctgccggtgcgcgcgctcttcacgcgcggc
gaggaccgggaccgcttcacccggcgctgtggcaccgacacagtggtgctctacgacgag
agcagcagcgactggaacgagaatacgggcggcgagtcggtgctcgggctgctgctcaag
aagctcaaggacgagggctgccgggcgttctacctggaaggtggcttcagtaagttccaa
gccgagttctccctgcattgcgagaccaatctagacggctcgtgtagcagcagctcgccg
ccgttgccagtgctggggctcgggggcctgcggatcagctctgactcttcctcggacatc
gagtctgaccttgaccgagaccccaatagtgcaacagactcggatggtagtccgctgtcc
aacagccagccttccttcccagtggagatcttgcccttcctctacttgggctgtgccaaa
gactccaccaacttggacgtgttggaggaattcggcatcaagtacatcttgaacgtcacc
cccaatttgccgaatctctttgagaacgcaggagagtttaaatacaagcaaatccccatc
tcggatcactggagccaaaacctgtcccagtttttccctgaggccatttctttcatagat
gaagcccggggcaagaactgtggtgtcttggtacattgcttggctggcattagccgctca
gtcactgtgactgtggcttaccttatgcagaagctcaatctgtcgatgaacgatgcctat
gacattgtcaaaatgaaaaaatccaacatatcccctaacttcaacttcatgggtcagctg
ctggacttcgagaggacgctgggactcagcagcccatgtgacaacagggttccagcacag
cagctgtattttaccaccccttccaaccagaatgtataccaggtggactctctgcaatct
acgtga

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