| Entry |
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| Symbol |
DYRK1A, DYRK, DYRK1, HP86, MNB, MNBH, MRD7
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| Name |
(RefSeq) dual specificity tyrosine phosphorylation regulated kinase 1A
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| KO |
| K08825 | dual specificity tyrosine-phosphorylation-regulated kinase 1 [EC:2.7.12.1] |
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| Organism |
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| Disease |
| H00773 | Autosomal dominant intellectual developmental disorder |
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| Drug target |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
1859 (DYRK1A)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:hsa04131]
1859 (DYRK1A)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.1 dual-specificity kinase
1859 (DYRK1A)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: CMGC group
DYRK family [OT]
1859 (DYRK1A)
Membrane trafficking [BR:hsa04131]
Endocytosis
Clathrin-mediated endocytosis
Kinases
1859 (DYRK1A)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
21:37365573..37526358
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| AA seq |
763 aa
MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD
QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ
QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV
EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM
LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR
SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL
FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT
RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK
KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG
HFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHH
HHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSS
STTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTY
QFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS |
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| NT seq |
2292 nt +upstreamnt +downstreamnt
atgcatacaggaggagagacttcagcatgcaaaccttcatctgttcggcttgcaccgtca
ttttcattccatgctgctggccttcagatggctggacagatgccccattcacatcagtac
agtgaccgtcgccagccaaacataagtgaccaacaggtttctgccttatcatattctgac
cagattcagcaacctctaactaaccaggtgatgcctgatattgtcatgttacagaggcgg
atgccccaaaccttccgtgacccagcaactgctcccctgagaaaactttctgttgacttg
atcaaaacatacaagcatattaatgaggtttactatgcaaaaaagaagcgaagacaccaa
cagggccagggagacgattctagtcataagaaggaacggaaggtttacaatgatggttat
gatgatgataactatgattatattgtaaaaaacggagaaaagtggatggatcgttacgaa
attgactccttgataggcaaaggttcctttggacaggttgtaaaggcatatgatcgtgtg
gagcaagaatgggttgccattaaaataataaagaacaagaaggcttttctgaatcaagca
cagatagaagtgcgacttcttgagctcatgaacaaacatgacactgaaatgaaatactac
atagtgcatttgaaacgccactttatgtttcgaaaccatctctgtttagtttttgaaatg
ctgtcctacaacctctatgacttgctgagaaacaccaatttccgaggggtctctttgaac
ctaacacgaaagtttgcgcaacagatgtgcactgcactgcttttccttgcgactccagaa
cttagtatcattcactgtgatctaaaacctgaaaatatccttctttgtaaccccaaacgc
agtgcaatcaagatagttgactttggcagttcttgtcagttggggcagaggatataccag
tatattcagagtcgcttttatcggtctccagaggtgctactgggaatgccttatgacctt
gccattgatatgtggtccctcgggtgtattttggttgaaatgcacactggagaacctctg
ttcagtggtgccaatgaggtagatcagatgaataaaatagtggaagttctgggtattcca
cctgctcatattcttgaccaagcaccaaaagcaagaaagttctttgagaagttgccagat
ggcacttggaacttaaagaagaccaaagatggaaaacgggagtacaaaccaccaggaacc
cgtaaacttcataacattcttggagtggaaacaggaggacctggtgggcgacgtgctggg
gagtcaggtcatacggtcgctgactacttgaagttcaaagacctcattttaaggatgctt
gattatgaccccaaaactcgaattcaaccttattatgctctgcagcacagtttcttcaag
aaaacagctgatgaaggtacaaatacaagtaatagtgtatctacaagccccgccatggag
cagtctcagtcttcgggcaccacctccagtacatcgtcaagctcaggtggctcatcgggg
acaagcaacagtgggagagcccggtcggatccgacgcaccagcatcggcacagtggtggg
cacttcacagctgccgtgcaggccatggactgcgagacacacagtccccaggtgcgtcag
caatttcctgctcctcttggttggtcaggcactgaagctcctacacaggtcactgttgaa
actcatcctgttcaagaaacaacctttcatgtagcccctcaacagaatgcattgcatcat
caccatggtaacagttcccatcaccatcaccaccaccaccaccatcaccaccaccatgga
caacaagccttgggtaaccggaccaggccaagggtctacaattctccaacgaatagctcc
tctacccaagattctatggaggttggccacagtcaccactccatgacatccctgtcttcc
tcaacgacttcttcctcgacatcttcctcctctactggtaaccaaggcaatcaggcctac
cagaatcgcccagtggctgctaataccttggactttggacagaatggagctatggacgtt
aatttgaccgtctactccaatccccgccaagagactggcatagctggacatccaacatac
caattttctgctaatacaggtcctgcacattacatgactgaaggacatctgacaatgagg
caaggggctgatagagaagagtcccccatgacaggagtttgtgtgcaacagagtcctgta
gctagctcgtga |
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