| Entry |
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| Symbol |
GALNS, GALNAC6S, GAS, GalN6S, MPS4A
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| Name |
(RefSeq) galactosamine (N-acetyl)-6-sulfatase
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| KO |
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| Organism |
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| Pathway |
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| Module |
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| Network |
nt06012 Glycosaminoglycan degradation |
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| Element |
| N00623 | Keratan sulfate degradation |
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| Disease |
| H00123 | Mucopolysaccharidosis type IV |
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| Drug target |
| Elosulfase alfa: | D10333<JP/US> |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09107 Glycan biosynthesis and metabolism
00531 Glycosaminoglycan degradation
2588 (GALNS)
09140 Cellular Processes
09141 Transport and catabolism
04142 Lysosome
2588 (GALNS)
Enzymes [BR:hsa01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.6 Sulfuric-ester hydrolases
3.1.6.4 N-acetylgalactosamine-6-sulfatase
2588 (GALNS)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
16:complement(88813734..88856947)
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| AA seq |
522 aa
MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLD
RMAAEGLLFPNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDS
EQLLPELLKKAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPV
YRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVY
ASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQG
GSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSD
RAIDGLNLLPTLLQGRLMDRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCP
GQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEALV
PAQPQLNVCNWAVMNWAPPGCEKLGKCLTPPESIPKKCLWSH |
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| NT seq |
1569 nt +upstreamnt +downstreamnt
atggcggcggttgtcgcggcgacgaggtggtggcagctgttgctggtgctcagcgccgcg
gggatgggggcctcgggcgccccgcagccccccaacatcctgctcctgctcatggacgac
atgggatggggtgacctcggggtgtatggagagccctccagagagaccccgaatttggac
cggatggctgcagaagggctgcttttcccaaacttctattctgccaaccctctgtgctcg
ccatcgagggcggcactgctcacaggacggctacccatccgcaatggcttctacaccacc
aacgcccatgccagaaacgcctacacaccgcaggagattgtgggcggcatcccagactcg
gagcagctcctgccggagcttctgaagaaggccggctacgtcagcaagattgtcggcaag
tggcatctgggtcacaggccccagttccaccccctgaagcacggatttgatgagtggttt
ggatcccccaactgccactttggaccttatgacaacaaggccaggcccaacatccctgtg
tacagggactgggagatggttggcagatattatgaagaatttcctattaatctgaagacg
ggggaagccaacctcacccagatctacctgcaggaagccctggacttcattaagagacag
gcacggcaccacccctttttcctctactgggctgtcgacgccacgcacgcacccgtctat
gcctccaaacccttcttgggcaccagtcagcgagggcggtatggagacgccgtccgggag
attgatgacagcattgggaagatactggagctcctccaagacctgcacgtcgcggacaac
accttcgtcttcttcacgtcggacaacggcgctgccctcatttccgcccccgaacaaggt
ggcagcaacggcccctttctgtgtgggaagcagaccacgtttgaaggagggatgagggag
cctgccctcgcatggtggccagggcacgtcactgcaggccaggtgagccaccagctgggc
agcatcatggacctcttcaccaccagcctggcccttgcgggcctgacgccgcccagcgac
agggccattgatggcctcaacctcctccccaccctcctgcagggccggctgatggacagg
cctatcttctattaccgtggcgacacgctgatggcggccaccctcgggcagcacaaggct
cacttctggacctggaccaactcctgggagaacttcagacagggcattgatttctgccct
gggcagaacgtttcaggggtcacaactcacaatctggaagaccacacgaagctgcccctg
atcttccacctgggacgggacccaggggagaggttccccctcagctttgccagcgccgag
taccaggaggccctcagcaggatcacctcggtcgtccagcagcaccaggaggccttggtc
cccgcgcagccccagctcaacgtgtgcaactgggcggtcatgaactgggcacctccgggc
tgtgaaaagttagggaagtgtctgacacctccagaatccattcccaagaagtgcctctgg
tcccactag |
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