| Entry |
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| Symbol |
MAP3K11, MEKK11, MLK-3, MLK3, PTK1, SPRK
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| Name |
(RefSeq) mitogen-activated protein kinase kinase kinase 11
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| KO |
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| Organism |
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| Pathway |
| hsa04932 | Non-alcoholic fatty liver disease |
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| Network |
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| Element |
| N01594 | MLK-JNK signaling pathway |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09160 Human Diseases
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
4296 (MAP3K11)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
4296 (MAP3K11)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.25 mitogen-activated protein kinase kinase kinase
4296 (MAP3K11)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: TKL group
MLK family
4296 (MAP3K11)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
11:complement(65597757..65614221)
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| AA seq |
847 aa
MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDEL
ALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLE
EVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALK
AVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHR
DLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFS
KGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWA
QDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSR
EEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKR
SKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEP
GQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPL
GSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRD
LQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPV
GQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWS
FVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAP
WVPEAGP |
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| NT seq |
2544 nt +upstreamnt +downstreamnt
atggagcccttgaagagcctcttcctcaagagccctctagggtcatggaatggcagtggc
agcgggggtggtgggggcggtggaggaggccggcctgaggggtctccaaaggcagcgggt
tatgccaacccggtgtggacagccctgttcgactacgagcccagtgggcaggatgagctg
gccctgaggaagggtgaccgtgtggaggtgctgtcccgggacgcagccatctcaggagac
gagggctggtgggcgggccaggtgggtggccaggtgggcatcttcccgtccaactatgtg
tctcggggtggcggcccgcccccctgcgaggtggccagcttccaggagctgcggctggag
gaggtgatcggcattggaggctttggcaaggtgtacaggggcagctggcgaggtgagctg
gtggctgtgaaggcagctcgccaggaccccgatgaggacatcagtgtgacagccgagagc
gttcgccaggaggcccggctcttcgccatgctggcacaccccaacatcattgccctcaag
gctgtgtgcctggaggagcccaacctgtgcctggtgatggagtatgcagccggtgggccc
ctcagccgagctctggccgggcggcgcgtgcctccccatgtgctggtcaactgggctgtg
cagattgcccgtgggatgcactacctgcactgcgaggccctggtgcccgtcatccaccgt
gatctcaagtccaacaacattttgctgctgcagcccattgagagtgacgacatggagcac
aagaccctgaagatcaccgactttggcctggcccgagagtggcacaaaaccacacaaatg
agtgccgcgggcacctacgcctggatggctcctgaggttatcaaggcctccaccttctct
aagggcagtgacgtctggagttttggggtgctgctgtgggaactgctgaccggggaggtg
ccataccgtggcattgactgccttgctgtggcctatggcgtagctgttaacaagctcaca
ctgcccatcccatccacctgccccgagcccttcgcacagcttatggccgactgctgggcg
caggacccccaccgcaggcccgacttcgcctccatcctgcagcagttggaggcgctggag
gcacaggtcctacgggaaatgccgcgggactccttccattccatgcaggaaggctggaag
cgcgagatccagggtctcttcgacgagctgcgagccaaggaaaaggaactactgagccgc
gaggaggagctgacgcgagcggcgcgcgagcagcggtcacaggcggagcagctgcggcgg
cgcgagcacctgctggcccagtgggagctagaggtgttcgagcgcgagctgacgctgctg
ctgcagcaggtggaccgcgagcgaccgcacgtgcgccgccgccgcgggacattcaagcgc
agcaagctccgggcgcgcgacggcggcgagcgtatcagcatgccactcgacttcaagcac
cgcatcaccgtgcaggcctcacccggccttgaccggaggagaaacgtcttcgaggtcggg
cctggggattcgcccacctttccccggttccgagccatccagttggagcctgcagagcca
ggccaggcatggggccgccagtccccccgacgtctggaggactcaagcaatggagagcgg
cgagcatgctgggcttggggtcccagttcccccaagcctggggaagcccagaatgggagg
agaaggtcccgcatggacgaagccacatggtacctggattcagatgactcatccccctta
ggatctccttccacacccccagcactcaatggtaaccccccgcggcctagcctggagccc
gaggagcccaagaggcctgtccccgcagagcgcggtagcagctctgggacgcccaagctg
atccagcgggcgctgctgcgcggcaccgccctgctcgcctcgctgggccttggccgcgac
ctgcagccgccgggaggcccaggacgcgagcgcggggagtccccgacaacaccccccacg
ccaacgcccgcgccctgcccgaccgagccgcccccttccccgctcatctgcttctcgctc
aagacgcccgactccccgcccactcctgcacccctgttgctggacctgggtatccctgtg
ggccagcggtcagccaagagcccccgacgtgaggaggagccccgcggaggcactgtctca
cccccaccggggacatcacgctctgctcctggcaccccaggcaccccacgttcaccaccc
ctgggcctcatcagccgacctcggccctcgccccttcgcagccgcattgatccctggagc
tttgtgtcagctgggccacggccttctcccctgccatcaccacagcctgcaccccgccga
gcaccctggaccttgttcccggactcagaccccttctgggactccccacctgccaacccc
ttccaggggggcccccaggactgcagggcacagaccaaagacatgggtgcccaggccccg
tgggtgccggaagcggggccttga |
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