| Entry |
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| Symbol |
EIF2AK4, GCN2, PVOD2
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| Name |
(RefSeq) eukaryotic translation initiation factor 2 alpha kinase 4
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| KO |
| K16196 | eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1] |
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| Organism |
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| Pathway |
| hsa05168 | Herpes simplex virus 1 infection |
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| Disease |
| H01621 | Pulmonary arterial hypertension |
| H01866 | Pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
440275 (EIF2AK4)
09160 Human Diseases
09172 Infectious disease: viral
05160 Hepatitis C
440275 (EIF2AK4)
05162 Measles
440275 (EIF2AK4)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
440275 (EIF2AK4)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
440275 (EIF2AK4)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: Other
PEK family [OT]
440275 (EIF2AK4)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
15:39934115..40035591
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| AA seq |
1649 aa
MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY
PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE
VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ
RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR
ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL
ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR
YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS
VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD
VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN
PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA
FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE
RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS
ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK
NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH
EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG
MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP
KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT
NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA
VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL
NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKF
IEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYK
VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK
ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ
EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG
REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQVQTRLQT
SLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVC
DEIYNIKVEKKVSVLFLYSYRDDYYRILF |
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| NT seq |
4950 nt +upstreamnt +downstreamnt
atggctgggggccgtggggcccccgggcgcggccgggacgagcctccggagagctacccg
caacgacaggaccacgagctacaggccctggaggccatttacggcgcggacttccaagac
ctgcggccggacgcttgcggaccggtcaaagagccccctgaaatcaatttagttttgtac
cctcaaggcctaactggtgaagaagtatatgtaaaagtggatttgagggttaaatgccca
cctacctatccagatgtagttcctgaaatagagttaaaaaatgccaaaggtctatcaaat
gaaagtgtcaatttgttaaaatctcgcctagaagaactggccaagaaacactgtggggag
gtgatgatctttgaactggcttaccacgtgcagtcatttctcagcgagcataacaagccc
cctcccaagtcttttcatgaagaaatgctggaaaggcgggctcaggaggagcagcagagg
ctgttggaggccaagcggaaagaagagcaggagcaacgtgaaatcctgcatgagattcag
agaaggaaagaagagataaaagaagagaaaaaaaggaaagaaatggctaagcaggaacgt
ttggaaattgctagtttgtcaaaccaagatcatacctctaagaaggacccaggaggacac
agaacggctgccattctacatggaggctctcctgactttgtaggaaatggtaaacatcgg
gcaaactcctcaggaaggtctaggcgagaacgtcagtattctgtatgtaatagtgaagat
tctcctggctcttgtgaaattctgtatttcaatatggggagtcctgatcagctcatggtg
cacaaagggaaatgtattggcagtgatgaacaacttggaaaattagtctacaatgctttg
gaaacagccactggtggctttgtcttgttgtatgagtgggtccttcagtggcagaaaaaa
atgggtccattccttaccagtcaagaaaaagagaagattgataagtgcaaaaagcagatt
caaggaacagaaacagaattcaactcactggtaaaattgagccatccaaatgtagtacgc
taccttgcaatgaatctcaaagagcaagacgactccatcgtggtggacattttagtggag
cacattagtggggtctctcttgctgcacacctgagccactcaggccccatccctgtgcat
cagcttcgcaggtacacagctcagctcctgtcaggccttgattatctgcacagcaattct
gtggtgcataaggtcctgagtgcatctaatgtcttggtggatgcagaaggcaccgtcaag
attacggactatagcatttctaagcgcctcgcagacatttgcaaggaggatgtgtttgag
caaacccgagttcgttttagtgacaatgctctgccttataaaacggggaagaaaggagat
gtttggcgtcttggccttctgctgctgtccctcagccaaggacaggaatgtggagagtac
cctgtgaccatccctagtgacttaccagctgactttcaagattttctaaagaaatgtgtg
tgcttggatgacaaggaaagatggagtccccagcagttgttgaaacacagctttataaat
ccccagccaaaaatgcctctagtggaacaaagtcctgaagattctgaaggacaagattat
gttgagactgttattcctagcaaccggctacccagtgctgccttctttagtgagacacag
agacagttttcccgatacttcattgagtttgaagaattacaacttcttggtaaaggagct
tttggagctgtcatcaaggtgcagaacaagttggacggctgctgctacgcagtgaagcgc
atccccatcaacccggccagccggcagttccgcaggatcaagggcgaagtgacactgctg
tcacggctgcaccatgagaacattgtgcgctactacaacgcctggatcgagcggcacgag
cggccggcgggaccggggacgccgcccccggactccgggcccctggccaaggatgaccga
gctgcacgcgggcagccggcgagcgacacagacggcctggacagcgtagaggccgccgcg
ccgccacccatcctcagcagctcggtggagtggagcacttcgggcgagcgctcggccagt
gcccgtttccccgccaccggcccgggctccagcgatgacgaggacgacgacgaggacgag
cacggtggcgtcttctcccagtccttcctgcctgcttcagattctgaaagtgatattatc
tttgacaatgaagatgagaacagtaaaagtcagaatcaggatgaagattgcaatgaaaag
aatggctgccatgaaagtgagccatcagtgacgactgaggctgtgcactacctatacatc
cagatggagtactgtgagaagagcactttacgagacaccattgaccagggactgtatcga
gacaccgtcagactctggaggctttttcgagagattctggatggattagcttatatccat
gagaaaggaatgattcaccgggatttgaagcctgtcaacatttttttggattctgatgac
catgtgaaaataggtgattttggtttggcgacagaccatctagccttttctgctgacagc
aaacaagacgatcagacaggagacttgattaagtcagacccttcaggtcacttaactggg
atggttggcactgctctctatgtaagcccagaggtccaaggaagcaccaaatctgcatac
aaccagaaagtggatctcttcagcctgggaattatcttctttgagatgtcctatcacccc
atggtcacggcttcagaaaggatctttgttctcaaccaactcagagatcccacttcgcct
aagtttccagaagactttgacgatggagagcatgcaaagcagaaatcagtcatctcctgg
ctgttgaaccacgatccagcaaaacggcccacagccacagaactgctcaagagtgagctg
ctgcccccaccccagatggaggagtcagagctgcatgaagtgctgcaccacacgctgacc
aacgtggatgggaaggcctaccgcaccatgatggcccagatcttctcgcagcgcatctcc
cctgccatcgattacacctatgacagcgacatactgaagggcaacttctcaatccgtaca
gccaagatgcagcagcatgtgtgtgaaaccatcatccgcatctttaaaagacatggagct
gttcagttgtgtactccactactgcttccccgaaacagacaaatatatgagcacaacgaa
gctgccctattcatggaccacagcgggatgctggtgatgcttccttttgacctgcggatc
ccttttgcaagatatgtggcaagaaataatatattgaatttaaaacgatactgcatagaa
cgtgtgttcaggccgcgcaagttagatcgatttcatcccaaagaacttctggagtgtgca
tttgatattgtcacttctaccaccaacagctttctgcccactgctgaaattatctacact
atctatgaaatcatccaagagtttccagcacttcaggaaagaaattacagtatttatttg
aaccataccatgttattgaaagcaatactcttacactgtgggatcccagaagataaactc
agtcaagtctacattattctgtatgatgctgtgacagagaagctgacgaggagagaagtg
gaagctaaattttgtaatctgtctttgtcttctaatagtctgtgtcgactctacaagttt
attgaacagaagggagatttgcaagatcttatgccaacaataaattcattaataaaacag
aaaacaggtattgcacagttggtgaagtatggcttaaaagacctagaggaggttgttgga
ctgttgaagaaactcggcatcaagttacaggtcttgatcaatttgggcttggtttacaag
gtgcagcagcacaatggaatcatcttccagtttgtggctttcatcaaacgaaggcaaagg
gctgtacctgaaatcctcgcagctggaggcagatatgacctgctgattccccagtttaga
gggccacaagctctggggccagttcccactgccattggggtcagcatagctatagacaag
atatctgctgctgtcctcaacatggaggaatctgttacaataagctcttgtgacctcctg
gttgtaagtgttggccagatgtctatgtccagggccatcaacctaacccagaaactctgg
acagcaggcatcacagcagaaatcatgtacgactggtcacagtcccaagaggaattacaa
gagtactgcagacatcatgaaatcacctatgtggcccttgtctcggataaagaaggaagc
catgtcaaggttaagtctttcgagaaggaaaggcagacagagaagcgtgtgctggagact
gaacttgtggaccatgtactgcagaaactgaggactaaagtcactgatgaaaggaatggc
agagaagcttccgataatcttgcagtgcaaaatctgaaggggtcattttctaatgcttca
ggtttgtttgaaatccatggagcaacagtggttcccattgtgagtgtgctagccccggag
aagctgtcagccagcactaggaggcgctatgaaactcaggtacaaactcgacttcagacc
tcccttgccaacttacatcagaaaagcagtgaaattgaaattctggctgtggatctaccc
aaagaaacaatattacagtttttatcattagagtgggatgctgatgaacaggcatttaac
acaactgtgaagcagctgctgtcacgcctgccaaagcaaagatacctcaaattagtctgt
gatgaaatttataacatcaaagtagaaaaaaaggtgtctgtgctatttctgtacagctat
agagatgactactacagaatcttattttaa |
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