KEGG   Homo sapiens (human): 51776
Entry
51776             CDS       T01001                                 
Symbol
MAP3K20, AZK, CNM6, MLK7, MLT, MLTK, MLTKalpha, MLTKbeta, MRK, SFMMP, ZAK, mlklak, pk
Name
(RefSeq) mitogen-activated protein kinase kinase kinase 20
  KO
K04424  sterile alpha motif and leucine zipper containing kinase AZK [EC:2.7.11.25]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
Network
nt06526  MAPK signaling
  Element
N01594  MLK-JNK signaling pathway
Disease
H00471  Split-hand/foot malformation
H00700  Centronuclear myopathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    51776 (MAP3K20)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     51776 (MAP3K20)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  MLK family
   51776 (MAP3K20)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SAM_1 SAM_2 SAM_PNT ABC1 SAM_Ste50p SAM_4 SAM_KIDINS220
Other DBs
NCBI-GeneID: 51776
NCBI-ProteinID: NP_057737
OMIM: 609479
HGNC: 17797
Ensembl: ENSG00000091436
UniProt: Q9NYL2
Structure
LinkDB
Position
2:173075517..173268015
AA seq 800 aa
MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL
SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY
LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS
LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH
QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD
LSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAE
MSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPL
IKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFNT
NLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKPQ
DEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSP
FFSHFDGQDSYAAAVRRPQVPIKYQQITPVNQSRSSSPTQYGLTKNFSSLHLNSRDSGFS
SGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHSTPSRGRYPGKFYRVSQS
ALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEEDSKVSEGGWTKVEYRKKPHRP
SPAKTNKERARGDHRGWRNF
NT seq 2403 nt   +upstreamnt  +downstreamnt
atgtcgtctctcggtgcctcctttgtgcaaattaaatttgatgacttgcagttttttgaa
aactgcggtggaggaagttttgggagtgtttatcgagccaaatggatatcacaggacaag
gaggtggctgtaaagaagctcctcaaaatagagaaagaggcagaaatactcagtgtcctc
agtcacagaaacatcatccagttttatggagtaattcttgaacctcccaactatggcatt
gtcacagaatatgcttctctgggatcactctatgattacattaacagtaacagaagtgag
gagatggatatggatcacattatgacctgggccactgatgtagccaaaggaatgcattat
ttacatatggaggctcctgtcaaggtgattcacagagacctcaagtcaagaaacgttgtt
atagctgctgatggagtattgaagatctgtgactttggtgcctctcggttccataaccat
acaacacacatgtccttggttggaactttcccatggatggctccagaagttatccagagt
ctccctgtgtcagaaacttgtgacacatattcctatggtgtggttctctgggagatgcta
acaagggaggtcccctttaaaggtttggaaggattacaagtagcttggcttgtagtggaa
aaaaacgagagattaaccattccaagcagttgccccagaagttttgctgaactgttacat
cagtgttgggaagctgatgccaagaaacggccatcattcaagcaaatcatttcaatcctg
gagtccatgtcaaatgacacgagccttcctgacaagtgtaactcattcctacacaacaag
gcggagtggaggtgcgaaattgaggcaactcttgagaggctaaagaaactagagcgtgat
ctcagctttaaggagcaggagcttaaagaacgagaaagacgtttaaagatgtgggagcaa
aagctgacagagcagtccaacaccccgctgctgccttcctttgagattggtgcatggacg
gaagacgatgtgtattgttgggttcagcagctcgtcagaaaaggtgactcttcagcagag
atgagtgtatatgcaagcttgtttaaagaaaacaacattacagggaagcggctgctgctg
ctggaggaagaagacctgaaagacatgggcattgtctccaaggggcatatcattcacttc
aagtcagccattgagaaattaacccatgattacataaatttgtttcacttcccaccacta
attaaggactcaggaggtgaacctgaagaaaatgaggaaaaaatagtgaacctggaactg
gtttttggttttcacttgaaaccaggaactggcccacaggattgtaagtggaaaatgtat
atggagatggatggggatgaaattgcaataacctacataaaagatgtgacattcaacact
aacctacctgatgcggagattttaaagatgacaaagccaccatttgtaatggagaagtgg
attgtaggaatagcaaaaagtcagactgtggagtgcactgtcacatatgagagtgatgtt
agaactccaaaaagcactaaacatgtccattcgattcagtggagtagaacaaaacctcag
gatgaagtgaaagcagtccaacttgccattcagacattattcaccaattcagatggcaac
cctggaagcaggtccgactcaagtgctgattgccagtggttagatactctgaggatgcgg
cagattgcatccaacacttctttacagcgttcccagagcaatcctattctggggtcaccg
ttcttctcacactttgatggccaggattcctacgctgctgctgtgagacggccccaggtg
cccattaagtatcaacagattacacctgtgaaccagtccagaagctcgtctcctactcag
tatggactgaccaaaaacttctcttccctacatctcaactctagggacagtggcttttcc
agtggcaatactgacacctcttcagagaggggtcgatactcagacagaagcaggaacaaa
tatggacgtggtagtatatcactcaattcttctcctagaggaagatacagtggaaagagt
cagcattccactccttcaagaggaagataccctggaaagttctacagggtttctcagtca
gcactcaatcctcaccagtcgcctgacttcaagagaagccccagggacctccaccaaccc
aacaccataccagggatgcctttgcaccctgagactgactcaagagccagtgaagaggac
agcaaagtcagcgaagggggctggacaaaagtggaataccggaaaaagccccacaggcca
tctcccgccaaaaccaataaagagagagccagaggggaccaccgtggatggagaaacttt
tga

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