Homo sapiens (human): 558 Help Entry 558               CDS       T01001                                  Symbol AXL, ARK, AXL3, JTK11, Tyro7, UFO Name (RefSeq) AXL receptor tyrosine kinase   KO K05115   AXL receptor tyrosine kinase [EC:2.7.10.1] Organism hsa  Homo sapiens (human) Pathway hsa01521   EGFR tyrosine kinase inhibitor resistance hsa04148   Efferocytosis Drug target Amuvatinib (DG01916):  D09864 D09865 Batiraxcept:  D12271 Bemcentinib:  D11438 Cabozantinib (DG01670):  D10062 D10095<JP/US> Dubermatinib (DG03093):  D11732 D11733 Mecbotamab:  D12219 Mecbotamab vedotin:  D12220 Merestinib:  D11763 Mipasetamab:  D12279 Mipasetamab uzoptirine:  D12280 Sitravatinib (DG03045):  D11140 D11541 Zanzalintinib (DG03273):  D12650 D12651 Brite KEGG Orthology (KO) [BR:hsa00001]  09140 Cellular Processes   09141 Transport and catabolism    04148 Efferocytosis     558 (AXL)  09160 Human Diseases   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     558 (AXL)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     558 (AXL) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      558 (AXL) Protein kinases [BR:hsa01001]  Receptor tyrosine kinases (RTK)   AXL family    558 (AXL) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase fn3 Ig_3 Ig_2 I-set ig V-set Pur_ac_phosph_N C1-set DUF2627 Pkinase_fungal Motif Other DBs NCBI-GeneID:  558 NCBI-ProteinID:  NP_068713 OMIM:  109135 HGNC:  905 Ensembl:  ENSG00000167601 UniProt:  P30530 Structure PDBPDBj LinkDB All DBs Position 19:41219223..41261766 Genome browser AA seq 894 aa AA seqDB search MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP VPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETR YGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGK TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA LMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA DPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA NT seq 2685 nt NT seq  +upstreamnt  +downstreamnt atggcgtggcggtgccccaggatgggcagggtcccgctggcctggtgcttggcgctgtgc ggctgggcgtgcatggcccccaggggcacgcaggctgaagaaagtcccttcgtgggcaac ccagggaatatcacaggtgcccggggactcacgggcacccttcggtgtcagctccaggtt cagggagagccccccgaggtacattggcttcgggatggacagatcctggagctcgcggac agcacccagacccaggtgcccctgggtgaggatgaacaggatgactggatagtggtcagc cagctcagaatcacctccctgcagctttccgacacgggacagtaccagtgtttggtgttt ctgggacatcagaccttcgtgtcccagcctggctatgttgggctggagggcttgccttac ttcctggaggagcccgaagacaggactgtggccgccaacacccccttcaacctgagctgc caagctcagggacccccagagcccgtggacctactctggctccaggatgctgtccccctg gccacggctccaggtcacggcccccagcgcagcctgcatgttccagggctgaacaagaca tcctctttctcctgcgaagcccataacgccaagggggtcaccacatcccgcacagccacc atcacagtgctcccccagcagccccgtaacctccacctggtctcccgccaacccacggag ctggaggtggcttggactccaggcctgagcggcatctaccccctgacccactgcaccctg caggctgtgctgtcagacgatgggatgggcatccaggcgggagaaccagaccccccagag gagcccctcacctcgcaagcatccgtgcccccccatcagcttcggctaggcagcctccat cctcacaccccttatcacatccgcgtggcatgcaccagcagccagggcccctcatcctgg acccactggcttcctgtggagacgccggagggagtgcccctgggcccccctgagaacatt agtgctacgcggaatgggagccaggccttcgtgcattggcaagagccccgggcgcccctg cagggtaccctgttagggtaccggctggcgtatcaaggccaggacaccccagaggtgcta atggacatagggctaaggcaagaggtgaccctggagctgcagggggacgggtctgtgtcc aatctgacagtgtgtgtggcagcctacactgctgctggggatggaccctggagcctccca gtacccctggaggcctggcgcccagggcaagcacagccagtccaccagctggtgaaggaa ccttcaactcctgccttctcgtggccctggtggtatgtactgctaggagcagtcgtggcc gctgcctgtgtcctcatcttggctctcttccttgtccaccggcgaaagaaggagacccgt tatggagaagtgtttgaaccaacagtggaaagaggtgaactggtagtcaggtaccgcgtg cgcaagtcctacagtcgtcggaccactgaagctaccttgaacagcctgggcatcagtgaa gagctgaaggagaagctgcgggatgtgatggtggaccggcacaaggtggccctggggaag actctgggagagggagagtttggagctgtgatggaaggccagctcaaccaggacgactcc atcctcaaggtggctgtgaagacgatgaagattgccatctgcacgaggtcagagctggag gatttcctgagtgaagcggtctgcatgaaggaatttgaccatcccaacgtcatgaggctc atcggtgtctgtttccagggttctgaacgagagagcttcccagcacctgtggtcatctta cctttcatgaaacatggagacctacacagcttcctcctctattcccggctcggggaccag ccagtgtacctgcccactcagatgctagtgaagttcatggcagacatcgccagtggcatg gagtatctgagtaccaagagattcatacaccgggacctggcggccaggaactgcatgctg aatgagaacatgtccgtgtgtgtggcggacttcgggctctccaagaagatctacaatggg gactactaccgccagggacgtatcgccaagatgccagtcaagtggattgccattgagagt ctagctgaccgtgtctacaccagcaagagcgatgtgtggtccttcggggtgacaatgtgg gagattgccacaagaggccaaaccccatatccgggcgtggagaacagcgagatttatgac tatctgcgccagggaaatcgcctgaagcagcctgcggactgtctggatggactgtatgcc ttgatgtcgcggtgctgggagctaaatccccaggaccggccaagttttacagagctgcgg gaagatttggagaacacactgaaggccttgcctcctgcccaggagcctgacgaaatcctc tatgtcaacatggatgagggtggaggttatcctgaaccccctggagctgcaggaggagct gaccccccaacccagccagaccctaaggattcctgtagctgcctcactgcggctgaggtc catcctgctggacgctatgtcctctgcccttccacaacccctagccccgctcagcctgct gataggggctccccagcagccccagggcaggaggatggtgcctga

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