KEGG   Homo sapiens (human): 5580
Entry
5580              CDS       T01001                                 
Symbol
PRKCD, ALPS3, CVID9, MAY1, PKCD, nPKC-delta
Name
(RefSeq) protein kinase C delta
  KO
K06068  novel protein kinase C delta type [EC:2.7.11.13]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04062  Chemokine signaling pathway
hsa04140  Autophagy - animal
hsa04270  Vascular smooth muscle contraction
hsa04621  NOD-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04722  Neurotrophin signaling pathway
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04912  GnRH signaling pathway
hsa04915  Estrogen signaling pathway
hsa04930  Type II diabetes mellitus
hsa04931  Insulin resistance
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa05020  Prion disease
hsa05131  Shigellosis
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05415  Diabetic cardiomyopathy
Network
nt06465  Prion disease
  Element
N01204  PRNP-PI3K-NOX2 signaling pathway
N01205  Scrapie conformation PrPSc to PRNP-PI3K-NOX2 signaling pathway
Disease
H00108  Autoimmune lymphoproliferative syndromes
Drug target
Delcasertib (DG02094): D10456 D10457
Safingol: D05784
Safingol hydrochloride: D05785
Sotrastaurin (DG01406): D09671 D09718
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    5580 (PRKCD)
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    5580 (PRKCD)
   04062 Chemokine signaling pathway
    5580 (PRKCD)
  09152 Endocrine system
   04915 Estrogen signaling pathway
    5580 (PRKCD)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    5580 (PRKCD)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5580 (PRKCD)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    5580 (PRKCD)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    5580 (PRKCD)
  09164 Neurodegenerative disease
   05020 Prion disease
    5580 (PRKCD)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    5580 (PRKCD)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    5580 (PRKCD)
   04931 Insulin resistance
    5580 (PRKCD)
   04933 AGE-RAGE signaling pathway in diabetic complications
    5580 (PRKCD)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    5580 (PRKCD)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.13  protein kinase C
     5580 (PRKCD)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  PKC family [OT]
   5580 (PRKCD)
SSDB
Motif
Pfam: Pkinase PKC_C2 PK_Tyr_Ser-Thr C1_1 Pkinase_C zf-RING-like C1_2 Kinase-like ABC1 PHD RH_dom PHDvar_NSD FYVE_2 FtrD-like
Other DBs
NCBI-GeneID: 5580
NCBI-ProteinID: NP_001303256
OMIM: 176977
HGNC: 9399
Ensembl: ENSG00000163932
UniProt: Q05655 B4DFV1
Structure
LinkDB
Position
3:53161209..53192717
AA seq 676 aa
MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD
AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY
FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW
GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS
PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR
RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF
GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK
DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL
LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE
MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH
PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF
AGFSFVNPKFEHLLED
NT seq 2031 nt   +upstreamnt  +downstreamnt
atggcgccgttcctgcgcatcgccttcaactcctatgagctgggctccctgcaggccgag
gacgaggcgaaccagcccttctgtgccgtgaagatgaaggaggcgctcagcacagagcgt
gggaaaacactggtgcagaagaagccgaccatgtatcctgagtggaagtcgacgttcgat
gcccacatctatgaggggcgcgtcatccagattgtgctaatgcgggcagcagaggagcca
gtgtctgaggtgaccgtgggtgtgtcggtgctggccgagcgctgcaagaagaacaatggc
aaggctgagttctggctggacctgcagcctcaggccaaggtgttgatgtctgttcagtat
ttcctggaggacgtggattgcaaacagtctatgcgcagtgaggacgaggccaagttccca
acgatgaaccgccgcggagccatcaaacaggccaaaatccactacatcaagaaccatgag
tttatcgccaccttctttgggcaacccaccttctgttctgtgtgcaaagactttgtctgg
ggcctcaacaagcaaggctacaaatgcaggcaatgtaacgctgccatccacaagaaatgc
atcgacaagatcatcggcagatgcactggcaccgcggccaacagccgggacactatattc
cagaaagaacgcttcaacatcgacatgccgcaccgcttcaaggttcacaactacatgagc
cccaccttctgtgaccactgcggcagcctgctctggggactggtgaagcagggattaaag
tgtgaagactgcggcatgaatgtgcaccataaatgccgggagaaggtggccaacctctgc
ggcatcaaccagaagcttttggctgaggccttgaaccaagtcacccagagagcctcccgg
agatcagactcagcctcctcagagcctgttgggatatatcagggtttcgagaagaagacc
ggagttgctggggaggacatgcaagacaacagtgggacctacggcaagatctgggagggc
agcagcaagtgcaacatcaacaacttcatcttccacaaggtcctgggcaaaggcagcttc
gggaaggtgctgcttggagagctgaagggcagaggagagtactttgccatcaaggccctc
aagaaggatgtggtcctgatcgacgacgacgtggagtgcaccatggttgagaagcgggtg
ctgacacttgccgcagagaatccctttctcacccacctcatctgcaccttccagaccaag
gaccacctgttctttgtgatggagttcctcaacgggggggacctgatgtaccacatccag
gacaaaggccgctttgaactctaccgtgccacgttttatgccgctgagataatgtgtgga
ctgcagtttctacacagcaagggcatcatttacagggacctcaaactggacaatgtgctg
ctggaccgggatggccacatcaagattgccgactttgggatgtgcaaagagaacatattc
ggggagagccgggccagcaccttctgcggcacccctgactatatcgcccctgagatccta
cagggcctgaagtacacattctctgtggactggtggtctttcggggtccttctgtacgag
atgctcattggccagtcccccttccatggtgatgatgaggatgaactcttcgagtccatc
cgtgtggacacgccacattatccccgctggatcaccaaggagtccaaggacatcctggag
aagctctttgaaagggaaccaaccaagaggctgggagtgaccggaaacatcaaaatccac
cccttcttcaagaccataaactggactctgctggaaaagcggaggttggagccacctttc
aggcccaaagtgaagtcacccagagactacagtaactttgaccaggagttcctgaacgag
aaggcgcgcctctcctacagcgacaagaacctcatcgactccatggaccagtctgcattc
gctggcttctcctttgtgaaccccaaattcgagcacctcctggaagattga

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