Homo sapiens (human): 5588 Help Entry 5588              CDS       T01001                                  Symbol PRKCQ, PRKCT, nPKC-theta Name (RefSeq) protein kinase C theta   KO K18052   novel protein kinase C theta type [EC:2.7.11.13] Organism hsa  Homo sapiens (human) Pathway hsa04064   NF-kappa B signaling pathway hsa04140   Autophagy - animal hsa04270   Vascular smooth muscle contraction hsa04658   Th1 and Th2 cell differentiation hsa04659   Th17 cell differentiation hsa04660   T cell receptor signaling pathway hsa04750   Inflammatory mediator regulation of TRP channels hsa04920   Adipocytokine signaling pathway hsa04931   Insulin resistance hsa05131   Shigellosis hsa05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Drug target Sotrastaurin (DG01406):  D09671 D09718 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04064 NF-kappa B signaling pathway     5588 (PRKCQ)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     5588 (PRKCQ)  09150 Organismal Systems   09151 Immune system    04660 T cell receptor signaling pathway     5588 (PRKCQ)    04658 Th1 and Th2 cell differentiation     5588 (PRKCQ)    04659 Th17 cell differentiation     5588 (PRKCQ)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     5588 (PRKCQ)  09160 Human Diseases   09161 Cancer: overview    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     5588 (PRKCQ)   09171 Infectious disease: bacterial    05131 Shigellosis     5588 (PRKCQ)   09167 Endocrine and metabolic disease    04931 Insulin resistance     5588 (PRKCQ)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     5588 (PRKCQ) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.13  protein kinase C      5588 (PRKCQ) Protein kinases [BR:hsa01001]  Serine/threonine kinases: AGC group   PKC family [OT]    5588 (PRKCQ) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Pkinase PKC_C2 PK_Tyr_Ser-Thr C1_1 Pkinase_C ABC1 Kinase-like zf-RING-like C1_2 Haspin_kinase PHDvar_NSD Motif Other DBs NCBI-GeneID:  5588 NCBI-ProteinID:  NP_001310194 OMIM:  600448 HGNC:  9410 Ensembl:  ENSG00000065675 UniProt:  Q04759 Structure PDBPDBj LinkDB All DBs Position 10:complement(6394097..6580646) Genome browser AA seq 706 aa AA seqDB search MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS NT seq 2121 nt NT seq  +upstreamnt  +downstreamnt atgtcgccatttcttcggattggcttgtccaactttgactgcgggtcctgccagtcttgt cagggcgaggctgttaacccttactgtgctgtgctcgtcaaagagtatgtcgaatcagag aacgggcagatgtatatccagaaaaagcctaccatgtacccaccctgggacagcactttt gatgcccatatcaacaagggaagagtcatgcagatcattgtgaaaggcaaaaacgtggac ctcatctctgaaaccaccgtggagctctactcgctggctgagaggtgcaggaagaacaac gggaagacagaaatatggttagagctgaaacctcaaggccgaatgctaatgaatgcaaga tactttctggaaatgagtgacacaaaggacatgaatgaatttgagacggaaggcttcttt gctttgcatcagcgccggggtgccatcaagcaggcaaaggtccaccacgtcaagtgccac gagttcactgccaccttcttcccacagcccacattttgctctgtctgccacgagtttgtc tggggcctgaacaaacagggctaccagtgccgacaatgcaatgcagcaattcacaagaag tgtattgataaagttatagcaaagtgcacaggatcagctatcaatagccgagaaaccatg ttccacaaggagagattcaaaattgacatgccacacagatttaaagtctacaattacaag agcccgaccttctgtgaacactgtgggaccctgctgtggggactggcacggcaaggactc aagtgtgatgcatgtggcatgaatgtgcatcatagatgccagacaaaggtggccaacctt tgtggcataaaccagaagctaatggctgaagcgctggccatgattgagagcactcaacag gctcgctgcttaagagatactgaacagatcttcagagaaggtccggttgaaattggtctc ccatgctccatcaaaaatgaagcaaggccgccatgtttaccgacaccgggaaaaagagag cctcagggcatttcctgggagtctccgttggatgaggtggataaaatgtgccatcttcca gaacctgaactgaacaaagaaagaccatctctgcagattaaactaaaaattgaggatttt atcttgcacaaaatgttggggaaaggaagttttggcaaggtcttcctggcagaattcaag aaaaccaatcaatttttcgcaataaaggccttaaagaaagatgtggtcttgatggacgat gatgttgagtgcacgatggtagagaagagagttctttccttggcctgggagcatccgttt ctgacgcacatgttttgtacattccagaccaaggaaaacctcttttttgtgatggagtac ctcaacggaggggacttaatgtaccacatccaaagctgccacaagttcgacctttccaga gcgacgttttatgctgctgaaatcattcttggtctgcagttccttcattccaaaggaata gtctacagggacctgaagctagataacatcctgttagacaaagatggacatatcaagatc gcggattttggaatgtgcaaggagaacatgttaggagatgccaagacgaataccttctgt gggacacctgactacatcgccccagagatcttgctgggtcagaaatacaaccactctgtg gactggtggtccttcggggttctcctttatgaaatgctgattggtcagtcgcctttccac gggcaggatgaggaggagctcttccactccatccgcatggacaatcccttttacccacgg tggctggagaaggaagcaaaggaccttctggtgaagctcttcgtgcgagaacctgagaag aggctgggcgtgaggggagacatccgccagcaccctttgtttcgggagatcaactgggag gaacttgaacggaaggagattgacccaccgttccggccgaaagtgaaatcaccatttgac tgcagcaatttcgacaaagaattcttaaacgagaagccccggctgtcatttgccgacaga gcactgatcaacagcatggaccagaatatgttcaggaacttttccttcatgaaccccggg atggagcggctgatatcctga

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