KEGG T01001: 6198

Homo sapiens (human): 6198

Entry

6198              CDS       T01001

Symbol

RPS6KB1, PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70_S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha

Name

(RefSeq) ribosomal protein S6 kinase B1

K04688

ribosomal protein S6 kinase beta [EC:2.7.11.1]

Organism

hsa Homo sapiens (human)

Pathway

hsa01521

EGFR tyrosine kinase inhibitor resistance

hsa01522

Endocrine resistance

hsa04012

ErbB signaling pathway

hsa04066

HIF-1 signaling pathway

hsa04140

Autophagy - animal

hsa04150

mTOR signaling pathway

hsa04151

PI3K-Akt signaling pathway

hsa04152

AMPK signaling pathway

hsa04211

Longevity regulating pathway

hsa04213

Longevity regulating pathway - multiple species

hsa04350

TGF-beta signaling pathway

hsa04371

Apelin signaling pathway

hsa04666

Fc gamma R-mediated phagocytosis

hsa04714

Thermogenesis

hsa04910

Insulin signaling pathway

hsa04931

Insulin resistance

hsa05131

Shigellosis

hsa05163

Human cytomegalovirus infection

hsa05165

Human papillomavirus infection

hsa05170

Human immunodeficiency virus 1 infection

hsa05200

Pathways in cancer

hsa05205

Proteoglycans in cancer

hsa05207

Chemical carcinogenesis - receptor activation

hsa05210

Colorectal cancer

hsa05212

Pancreatic cancer

hsa05221

Acute myeloid leukemia

hsa05224

Breast cancer

hsa05225

Hepatocellular carcinoma

hsa05226

Gastric cancer

hsa05231

Choline metabolism in cancer

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

Network

nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06214  PI3K signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06270  Breast cancer
nt06273  Glioma
nt06275  Acute myeloid leukemia
nt06462  Spinocerebellar ataxia

Element

N00034

ERBB2-overexpression to PI3K signaling pathway

N00037

FGF-FGFR-PI3K signaling pathway

N00039

PDGF-PDGFR-PI3K signaling pathway

N00042

EGFR-overexpression to PI3K signaling pathway

N00045

KITLG-KIT-PI3K signaling pathway

N00049

Mutation-activated PI3K to PI3K signaling pathway

N00050

Amplified PI3K to PI3K signaling pathway

N00234

IGF2-IGF1R-PI3K signaling pathway

N00236

IGF2-overexpression to PI3K signaling pathway

N00238

IGF1R-overexpression to PI3K signaling pathway

N00253

Amplified ERBB2 to PI3K signaling pathway

N00282

EREG-EGFR-PI3K signaling pathway

N00283

EREG-overexpression to PI3K signaling pathway

N00284

AREG-EGFR-PI3K signaling pathway

N00285

AREG-overexpression to PI3K signaling pathway

N00963

RELN-VLDLR-PI3K signaling pathway

N01355

Arsenic to PI3K signaling pathway

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    6198 (RPS6KB1)
   04066 HIF-1 signaling pathway
    6198 (RPS6KB1)
   04151 PI3K-Akt signaling pathway
    6198 (RPS6KB1)
   04152 AMPK signaling pathway
    6198 (RPS6KB1)
   04150 mTOR signaling pathway
    6198 (RPS6KB1)
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    6198 (RPS6KB1)
09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    6198 (RPS6KB1)
  09149 Aging
   04211 Longevity regulating pathway
    6198 (RPS6KB1)
   04213 Longevity regulating pathway - multiple species
    6198 (RPS6KB1)
  09159 Environmental adaptation
   04714 Thermogenesis
    6198 (RPS6KB1)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    6198 (RPS6KB1)
   05205 Proteoglycans in cancer
    6198 (RPS6KB1)
   05207 Chemical carcinogenesis - receptor activation
    6198 (RPS6KB1)
   05231 Choline metabolism in cancer
    6198 (RPS6KB1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    6198 (RPS6KB1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    6198 (RPS6KB1)
   05212 Pancreatic cancer
    6198 (RPS6KB1)
   05225 Hepatocellular carcinoma
    6198 (RPS6KB1)
   05226 Gastric cancer
    6198 (RPS6KB1)
   05221 Acute myeloid leukemia
    6198 (RPS6KB1)
   05224 Breast cancer
    6198 (RPS6KB1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    6198 (RPS6KB1)
   05163 Human cytomegalovirus infection
    6198 (RPS6KB1)
   05165 Human papillomavirus infection
    6198 (RPS6KB1)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    6198 (RPS6KB1)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    6198 (RPS6KB1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    6198 (RPS6KB1)
   01522 Endocrine resistance
    6198 (RPS6KB1)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    6198 (RPS6KB1)
Enzymes [BR:hsa01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     6198 (RPS6KB1)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: AGC group
  RSK family [OT]
   6198 (RPS6KB1)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr Pkinase_C Kinase-like Pkinase_fungal ABC1 DUF1015

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

17:59893121..59950574

AA seq 525 aa
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL
LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLE
SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG
IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL

NT seq 1578 nt +upstreamnt +downstreamnt
atgaggcgacgaaggaggcgggacggcttttacccagccccggacttccgagacagggaa
gctgaggacatggcaggagtgtttgacatagacctggaccagccagaggacgcgggctct
gaggatgagctggaggaggggggtcagttaaatgaaagcatggaccatgggggagttgga
ccatatgaacttggcatggaacattgtgagaaatttgaaatctcagaaactagtgtgaac
agagggccagaaaaaatcagaccagaatgttttgagctacttcgggtacttggtaaaggg
ggctatggaaaggtttttcaagtacgaaaagtaacaggagcaaatactgggaaaatattt
gccatgaaggtgcttaaaaaggcaatgatagtaagaaatgctaaagatacagctcataca
aaagcagaacggaatattctggaggaagtaaagcatcccttcatcgtggatttaatttat
gcctttcagactggtggaaaactctacctcatccttgagtatctcagtggaggagaacta
tttatgcagttagaaagagagggaatatttatggaagacactgcctgcttttacttggca
gaaatctccatggctttggggcatttacatcaaaaggggatcatctacagagacctgaag
ccggagaatatcatgcttaatcaccaaggtcatgtgaaactaacagactttggactatgc
aaagaatctattcatgatggaacagtcacacacacattttgtggaacaatagaatacatg
gcccctgaaatcttgatgagaagtggccacaatcgtgctgtggattggtggagtttggga
gcattaatgtatgacatgctgactggagcacccccattcactggggagaatagaaagaaa
acaattgacaaaatcctcaaatgtaaactcaatttgcctccctacctcacacaagaagcc
agagatctgcttaaaaagctgctgaaaagaaatgctgcttctcgtctgggagctggtcct
ggggacgctggagaagttcaagctcatccattctttagacacattaactgggaagaactt
ctggctcgaaaggtggagcccccctttaaacctctgttgcaatctgaagaggatgtaagt
cagtttgattccaagtttacacgtcagacacctgtcgacagcccagatgactcaactctc
agtgaaagtgccaatcaggtctttctgggttttacatatgtggctccatctgtacttgaa
agtgtgaaagaaaagttttcctttgaaccaaaaatccgatcacctcgaagatttattggc
agcccacgaacacctgtcagcccagtcaaattttctcctggggatttctggggaagaggt
gcttcggccagcacagcaaatcctcagacacctgtggaatacccaatggaaacaagtggc
atagagcagatggatgtgacaatgagtggggaagcatcggcaccacttccaatacgacag
ccgaactctgggccatacaaaaaacaagcttttcccatgatctccaaacggccagagcac
ctgcgtatgaatctatga

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