| Entry |
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| Symbol |
WNK4, PHA2B, PRKWNK4
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| Name |
(RefSeq) WNK lysine deficient protein kinase 4
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| KO |
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| Organism |
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| Pathway |
| hsa04928 | Parathyroid hormone synthesis, secretion and action |
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| Network |
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| Element |
| N01823 | FGF23-NCC/NPT signaling pathway |
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| Disease |
| H00243 | Hyperkalemic distal renal tubular acidosis (RTA type 4) |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09150 Organismal Systems
09152 Endocrine system
04928 Parathyroid hormone synthesis, secretion and action
65266 (WNK4)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
65266 (WNK4)
01009 Protein phosphatases and associated proteins [BR:hsa01009]
65266 (WNK4)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
65266 (WNK4)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: Other
Wnk family
65266 (WNK4)
Protein phosphatases and associated proteins [BR:hsa01009]
Protein serine/threonine phosphatases
Phosphoprotein phosphatases (PPPs)
Protein phosphatase-1
PP1-interacting proteins (PIPs)
65266 (WNK4)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
17:42780610..42797066
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| AA seq |
1243 aa
MLASPATETTVLMSQTEADLALRPPPPLGTAGQPRLGPPPRRARRFSGKAEPRPRSSRLS
RRSSVDLGLLSSWSLPASPAPDPPDPPDSAGPGPARSPPPSSKEPPEGTWTEGAPVKAAE
DSARPELPDSAVGPGSREPLRVPEAVALERRREQEEKEDMETQAVATSPDGRYLKFDIEI
GRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSW
KSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILH
RDLKCDNVFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDEAVDVYA
FGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEVKEIIEGCIRTDKNER
FTIQDLLAHAFFREERGVHVELAEEDDGEKPGLKLWLRMEDARRGGRPRDNQAIEFLFQL
GRDAAEEVAQEMVALGLVCEADYQPVARAVRERVAAIQRKREKLRKARELEALPPEPGPP
PATVPMAPGPPSVFPPEPEEPEADQHQPFLFRHASYSSTTSDCETDGYLSSSGFLDASDP
ALQPPGGVPSSLAESHLCLPSAFALSIPRSGPGSDFSPGDSYASDAASGLSDVGEGMGQM
RRPPGRNLRRRPRSRLRVTSVSDQNDRVVECQLQTHNSKMVTFRFDLDGDSPEEIAAAMV
YNEFILPSERDGFLRRIREIIQRVETLLKRDTGPMEAAEDTLSPQEEPAPLPALPVPLPD
PSNEELQSSTSLEHRSWTAFSTSSSSPGTPLSPGNPFSPGTPISPGPIFPITSPPCHPSP
SPFSPISSQVSSNPSPHPTSSPLPFSSSTPEFPVPLSQCPWSSLPTTSPPTFSPTCSQVT
LSSPFFPPCPSTSSFPSTTAAPLLSLASAFSLAVMTVAQSLLSPSPGLLSQSPPAPPSPL
PSLPLPPPVAPGGQESPSPHTAEVESEASPPPARPLPGEARLAPISEEGKPQLVGRFQVT
SSKEPAEPLPLQPTSPTLSGSPKPSTPQLTSESSDTEDSAGGGPETREALAESDRAAEGL
GAGVEEEGDDGKEPQVGGSPQPLSHPSPVWMNYSYSSLCLSSEESESSGEDEEFWAELQS
LRQKHLSEVETLQTLQKKEIEDLYSRLGKQPPPGIVAPAAMLSSRQRRLSKGSFPTSRRN
SLQRSEPPGPGIMRRNSLSGSSTGSQEQRASKGVTFAGDVGRM |
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| NT seq |
3732 nt +upstreamnt +downstreamnt
atgttggcatccccggccacggagaccaccgtcctcatgtcccagactgaggccgacctg
gccctgcggcccccgcctcctcttggcaccgcggggcagccccgcctcgggccccctcct
cgccgagcgcgccgcttctccgggaaggctgagccccggccgcgctcttctcgtctcagc
cgccgtagctcagtcgacttggggctgctgagctcttggtccctgccagcctcacccgct
ccggacccccccgatcctccggactccgctggtcctggccccgcgaggagcccaccgcct
agctccaaagaaccccccgagggcacgtggaccgagggagcccctgtgaaggctgcggaa
gactccgcgcgtcccgagctcccggactctgcagtgggcccggggtccagggagccgcta
agggtccctgaagctgtggccctagagcggcggcgggagcaggaagaaaaggaggacatg
gagacccaggctgtggcaacgtcccccgatggccgatacctcaagtttgacatcgagatt
ggacgtggctccttcaagacggtgtatcgagggctagacaccgacaccacagtggaggtg
gcctggtgtgagctgcagactcggaaactgtctagagctgagcggcagcgcttctcagag
gaggtggagatgctcaaggggctgcagcaccccaacatcgtccgcttctatgattcgtgg
aagtcggtgctgaggggccaggtttgcatcgtgctggtcaccgaactcatgacctcgggc
acgctcaagacgtacctgaggcggttccgggagatgaagccgcgggtccttcagcgctgg
agccgccaaatcctgcggggacttcatttcctacactcccgggttcctcccatcctgcac
cgggatctcaagtgcgacaatgtctttatcacgggacctactggctctgtcaaaatcggg
gacctgggcctggccacgctcaagcgcgcctcctttgccaagagtgtcatcgggaccccg
gaattcatggcccccgagatgtacgaggaaaagtacgatgaggccgtggacgtgtacgcg
ttcggcatgtgcatgctggagatggccacctctgagtacccgtactccgagtgccagaat
gccgcgcaaatctaccgcaaggtcacttcgggcagaaagccgaacagcttccacaaggtg
aagatacccgaggtgaaggagatcattgaaggctgcatccgcacggataagaacgagagg
ttcaccatccaggacctcctggcccacgccttcttccgcgaggagcgcggtgtgcacgtg
gaactagcggaggaggacgacggcgagaagccgggcctcaagctctggctgcgcatggag
gacgcgcggcgcggggggcgcccacgggacaaccaggccatcgagttcctgttccagctg
ggccgggacgcggccgaggaggtggcacaggagatggtggctctgggcttggtctgtgaa
gccgattaccagccagtggcccgtgcagtacgtgaacgggttgctgccatccagcgaaag
cgtgagaagctgcgtaaagcaagggaattggaggcactcccaccagagccaggacctcca
ccagcaactgtgcccatggcccccggtccccccagtgtcttcccccctgagcctgaggag
ccagaggcagaccagcaccagcccttccttttccgccacgccagctactcatctaccact
tcggattgcgagactgatggctacctcagctcctccggcttcctggatgcctcagaccct
gcccttcagccccctgggggggtgccatccagcctggctgagtcccatctctgcctgccc
tcggcttttgccctatccattccacgttctggccctggaagtgacttttcccccggggac
agctatgcctcagatgcagcttcaggccttagcgatgtgggagaagggatgggacaaatg
aggagacccccagggaggaatctccggcgcagaccccgatcccggctgcgggtcactagt
gtctcagaccagaatgacagagtggttgagtgccagctacagacccataacagcaagatg
gtgaccttccgatttgatctggatggggacagcccggaagagattgcagctgccatggta
tataacgagttcattctgccttcggagcgagatggatttctcagacggattcgggagatt
atccagcgagtggagaccctgttgaagagagacactggccccatggaggctgctgaagac
accctaagcccccaggaggagccagcaccattacctgccctgcccgtccccctcccagac
ccatccaatgaagagctccagagcagcacctccctggagcacaggagctggacagccttc
tccacctcctcatcttctcctggaactcctttgtctcctggaaacccattttcccctgga
acccccatttccccaggtcccatcttccccatcacttctcccccatgtcatcccagcccc
tccccattctcccccatttcttcccaggtctcctcaaatccctctccacaccccaccagc
tctccacttccattctcctccagcacacccgagtttccggtcccactctctcagtgtccc
tggagttctctccccacgacttctccacctacgttctctcccacttgttctcaggtcact
cttagttcccctttctttcctccgtgcccctccacttcttccttcccctccaccacagca
gcccctctcctttctctggctagtgccttctcactggctgtgatgactgtggcccagtcc
ctgctgtccccctcacctgggctcctttcccagtctcctccagcccctcctagtcccctc
cctagcctgccccttccccctcccgttgctcctggtggccaggaaagcccttcaccccac
acagctgaggtggagagtgaggcctcaccacctcctgctcggcccctcccaggggaagcc
aggctggcgcccatctctgaagagggaaagccgcagcttgttgggcgtttccaagtgact
tcatccaaggaaccggctgagcctcttcccttgcagccaacatcccccactctctctggt
tctccaaaaccttcaacccctcagctcacttcagagagctcagatacagaggacagtgct
ggaggcgggccagagaccagggaagctctggctgagagcgaccgtgcagctgagggtctg
ggggctggagttgaggaggaaggagatgatgggaaggaaccccaagttgggggcagcccc
caacccctgagccatcccagcccagtgtggatgaactactcctacagcagcctgtgtttg
agcagcgaggagtcagaaagcagtggggaagatgaggagttctgggctgagctgcagagt
cttcggcagaagcacttgtcagaggtggaaacactacagacactacagaaaaaagaaatt
gaagatttgtacagccggctggggaagcagcccccaccgggtattgtggccccagctgct
atgctgtccagccgccagcgccgcctctccaagggcagcttccccacctcccgccgcaac
agcctacagcgctctgagcccccaggccctggcatcatgcgaaggaactctctgagtggc
agcagcaccggctcccaggagcagcgggcaagcaagggggtgacattcgccggggatgtt
ggcaggatgtga |
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