Homo sapiens (human): 6850
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Entry
6850 CDS
T01001
Symbol
SYK, IMD82, p72-Syk
Name
(RefSeq) spleen associated tyrosine kinase
KO
K05855
spleen tyrosine kinase [EC:
2.7.10.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04064
NF-kappa B signaling pathway
hsa04072
Phospholipase D signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04380
Osteoclast differentiation
hsa04611
Platelet activation
hsa04613
Neutrophil extracellular trap formation
hsa04625
C-type lectin receptor signaling pathway
hsa04650
Natural killer cell mediated cytotoxicity
hsa04662
B cell receptor signaling pathway
hsa04664
Fc epsilon RI signaling pathway
hsa04666
Fc gamma R-mediated phagocytosis
hsa05152
Tuberculosis
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05171
Coronavirus disease - COVID-19
hsa05203
Viral carcinogenesis
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06165
Epstein-Barr virus (EBV)
nt06220
Calcium signaling (cancer)
nt06537
TCR/BCR signaling
Element
N00266
EBV LMP2A to PI3K signaling pathway
N00487
BCR-PLCG-Calcineurin signaling pathway
N00488
EBV LMP2A to BCR signaling pathway
N01695
BCR-BCAP/CD19-PI3K signaling pathway
Disease
H02526
Disorders of adaptive immunity
Drug target
Entospletinib:
D11209
Fostamatinib (
DG01419
):
D09347
D09348
<JP/US>
Gusacitinib (
DG03080
):
D11676
D11677
Mivavotinib (
DG03106
):
D11789
D11790
Tuspetinib:
D12476
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04064 NF-kappa B signaling pathway
6850 (SYK)
04072 Phospholipase D signaling pathway
6850 (SYK)
04151 PI3K-Akt signaling pathway
6850 (SYK)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
6850 (SYK)
04613 Neutrophil extracellular trap formation
6850 (SYK)
04625 C-type lectin receptor signaling pathway
6850 (SYK)
04650 Natural killer cell mediated cytotoxicity
6850 (SYK)
04662 B cell receptor signaling pathway
6850 (SYK)
04664 Fc epsilon RI signaling pathway
6850 (SYK)
04666 Fc gamma R-mediated phagocytosis
6850 (SYK)
09158 Development and regeneration
04380 Osteoclast differentiation
6850 (SYK)
09160 Human Diseases
09161 Cancer: overview
05203 Viral carcinogenesis
6850 (SYK)
09172 Infectious disease: viral
05171 Coronavirus disease - COVID-19
6850 (SYK)
05168 Herpes simplex virus 1 infection
6850 (SYK)
05167 Kaposi sarcoma-associated herpesvirus infection
6850 (SYK)
05169 Epstein-Barr virus infection
6850 (SYK)
09171 Infectious disease: bacterial
05152 Tuberculosis
6850 (SYK)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
6850 (SYK)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
6850 (SYK)
Protein kinases [BR:
hsa01001
]
Non-receptor tyrosine kinases
SYK family
6850 (SYK)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
SH2
Kdo
ABC1
Motif
Other DBs
NCBI-GeneID:
6850
NCBI-ProteinID:
NP_001167638
OMIM:
600085
HGNC:
11491
Ensembl:
ENSG00000165025
UniProt:
P43405
Structure
PDB
LinkDB
All DBs
Position
9:90801600..90898549
Genome browser
AA seq
635 aa
AA seq
DB search
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
NT seq
1908 nt
NT seq
+upstream
nt +downstream
nt
atggccagcagcggcatggctgacagcgccaaccacctgcccttctttttcggcaacatc
acccgggaggaggcagaagattacctggtccaggggggcatgagtgatgggctttatttg
ctgcgccagagccgcaactacctgggtggcttcgccctgtccgtggcccacgggaggaag
gcacaccactacaccatcgagcgggagctgaatggcacctacgccatcgccggtggcagg
acccatgccagccccgccgacctctgccactaccactcccaggagtctgatggcctggtc
tgcctcctcaagaagcccttcaaccggccccaaggggtgcagcccaagactgggcccttt
gaggatttgaaggaaaacctcatcagggaatatgtgaagcagacatggaacctgcagggt
caggctctggagcaggccatcatcagtcagaagcctcagctggagaagctgatcgctacc
acagcccatgaaaaaatgccttggttccatggaaaaatctctcgggaagaatctgagcaa
attgtcctgataggatcaaagacaaatggaaagttcctgatccgagccagagacaacaac
ggctcctacgccctgtgcctgctgcacgaagggaaggtgctgcactatcgcatcgacaaa
gacaagacagggaagctctccatccccgagggaaagaagttcgacacgctctggcagcta
gtcgagcattattcttataaagcagatggtttgttaagagttcttactgtcccatgtcaa
aaaatcggcacacagggaaatgttaattttggaggccgtccacaacttccaggttcccat
cctgcgacttggtcagcgggtggaataatctcaagaatcaaatcatactccttcccaaag
cctggccacagaaagtcctcccctgcccaagggaaccggcaagagagtactgtgtcattc
aatccgtatgagccagaacttgcaccctgggctgcagacaaaggcccccagagagaagcc
ctacccatggacacagaggtgtacgagagcccctacgcggaccccgaggagatcaggccc
aaggaggtttacctggaccgaaagctgctgacgctggaagacaaagaactgggctctggt
aattttggaactgtgaaaaagggctactaccaaatgaaaaaagttgtgaaaaccgtggct
gtgaaaatactgaaaaacgaggccaatgaccccgctcttaaagatgagttattagcagaa
gcaaatgtcatgcagcagctggacaacccgtacatcgtgcggatgatcgggatatgcgag
gccgagtcctggatgctggttatggagatggcagaacttggtcccctcaataagtatttg
cagcagaacagacatgtcaaggataagaacatcatagaactggttcatcaggtttccatg
ggcatgaagtacttggaggagagcaattttgtgcacagagatctggctgcaagaaatgtg
ttgctagttacccaacattacgccaagatcagtgatttcggactttccaaagcactgcgt
gctgatgaaaactactacaaggcccagacccatggaaagtggcctgtcaagtggtacgct
ccggaatgcatcaactactacaagttctccagcaaaagcgatgtctggagctttggagtg
ttgatgtgggaagcattctcctatgggcagaagccatatcgagggatgaaaggaagtgaa
gtcaccgctatgttagagaaaggagagcggatggggtgccctgcagggtgtccaagagag
atgtacgatctcatgaatctgtgctggacatacgatgtggaaaacaggcccggattcgca
gcagtggaactgcggctgcgcaattactactatgacgtggtgaactaa
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